endostatin
Basics
Aliases:
This biomarker is also known as:- collagen, type XVIII, alpha 1,
- collagen alpha-1(XVIII) chain,
- human type XVIII collagen,
- COL18A1,
- KNO,
- KS,
- KNO1,
- multi-functional protein MFP,
- Knobloch syndrome, type 1,
- antiangiogenic agent,
Description…
COL18A1, also known as endostatin, is the alpha chain of type XVIII collagen. COL18A1 is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. It also inhibits endothelial cell proliferation and angiogenesis, and may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | COL18A1 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Lung
Attributes
| Phase: | Two |
|---|---|
| QA State: | Curated |
Overview
Endostatin, best known as an inhibitor of angiogenesis, has elevated serum levels in several cancers. Overexpression of endostatin and its parent extracellular matrix protein, collagen XVIII have been associated with poor prognosis in NSCLC (non-small cell lung cancer).
Performance Comment
Serum endostatin levels may be useful markers for NSCLC (non-small cell lung cancer). Endostatin is also a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Integral protein microarrays for the identification of lung cancer antigens in sera that induce a humoral immune response.
- Aberrant silencing of the endocrine peptide gene tachykinin-1 in gastric cancer.
- Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling.
Resources
External Resources for endostatin
Gene
- Entrez entry for endostatin all NCBI Databasese
- Find Human Single Nucleotide Polymorphisms info for endostatin
- GeneCards entry for human endostatin
Protein
- UniProtKB/Swiss-Prot entry for endostatin from Uniprot
- Human Protein RefSeq for endostatin from NCBI
Other
No other associated resources found.
Biomuta
Mutation Statistics
| Gene Name: | COL18A1 |
|---|---|
| UniProt Accession #: | P39060 |
| Mutated Sites Count: | 403 |
| Associated Pubmed ID Count | 15 |
| CancerDO Count | 24 |
| Affected Protein Function Sites Count: | 4 |
