Aliases:This biomarker is also known as:
CDKN2A locus gives rise to 2 distinct transcripts from different promoters: p16 (INK4A) and p14 (ARF). Each has a 5-prime exon which is spliced into common exons 2 and 3 but in some sequences in a different reading frame. The beta transcript of CDKN2A encodes p14(ARF). P14/ARF has the ability to elicit a p53 response, which results in increased expression of both CDKN1A, also called CIP1, and MDM2, resulting in a cell cycle arrest in both the G1 and G2/M phases. p14/ARF binds to MDM2 and promotes the rapid degradation of MDM2. The deletion of the ARF-INK4A locus simultaneously impairs the INK4A--cyclin D/CDK4--RB and the ARF--MDM2--p53 pathways.
|QA State:||Under Review|
There are no datasets associated with this biomarker.