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CDH13

Basics

Aliases:
This biomarker is also known as:
  • cadherin 13,
  • truncated-cadherin,
  • T-cadherin,
  • H-cadherin (heart),
  • P105,
  • T-cad,
  • heart-cadherin,
  • H-cadherin,

Description…

CDH13 is a member of the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region but, unlike the typical cadherin superfamily member, lacks the highly conserved cytoplasmic region. This particular cadherin is a putative mediator of cell-cell interaction in the heart and may act as a negative regulator of neural cell growth. The gene locus is hypermethylated or deleted in breast, ovarian and lung cancers.

Attributes

QA State: Accepted
Type: Genomic
Short Name:
HGNC Name: CDH13

Organs

The following organs have data associated with this biomarker…

Esophagus

Attributes

Phase: Two
QA State: Accepted

Overview

Esophageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.

Performance Comment

Levels of CDH13 hypermethylation have been shown to discriminate esophageal adenocarcinoma from esophageal squamous cell carcinoma and normal esophagus. CDH13 is also being investigated as a biomarker for progression from Barrett's esophagus to esophageal adenocarcinoma. Studies are ongoing.

Supporting Study Data

The following studies/protocols provide evidence supporting CDH13 indications for the Esophagus…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Lung

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Supporting Study Data

The following studies/protocols provide evidence supporting CDH13 indications for the Lung…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: CDH13
UniProt Accession #: P55290
Mutated Sites Count: 258
Associated Pubmed ID Count 14
CancerDO Count 27
Affected Protein Function Sites Count: 4

View in BioMuta