Aliases:This biomarker is also known as:
- membrane glycoprotein gp140,
- Transmembrane and associated with src kinases,
- Subtractive immunization M plus HEp3-associated 135 kDa protein,
- CD318 antigen,
- CUB domain containing protein 1,
- transmembrane and associated with src kinases,
- subtractive immunization M plus HEp3-associated 135 kDa protein,
- CUB domain-containing protein 1,
- Membrane glycoprotein gp140,
CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. CDCP1 is located on the cell surface and may be involved in cell adhesion and cell matrix association. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
CDCP1 is a transmembrane tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.
CDCP1 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of CDCP1 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.
- HGNC entry for CDCP1 from Genenames
- KEGG entry for CDCP1 from Genome.jp
- Entrez entry for CDCP1 all NCBI Databasese
- Human GEO Profiles for CDCP1 from NCBI GEO Profiles
- Human Geo Datasets containing term CDCP1 from NCBI GEO Datasets
- GWAS Study Datasets containing gene CDCP1 from GWAS
- Human Single Nucleotide Polymorphisms info for CDCP1
- Human Gene(s) with 'CDCP1' as Gene Name/Alias
- Human Gene RefSeq for CDCP1 from NCBI
- GeneCards entry for human CDCP1
- UniProtKB/Swiss-Prot entry for CDCP1 from Uniprot
- Human Protein RefSeq for CDCP1 from NCBI
- FDA web page describing approval of CDCP1
|UniProt Accession #:||Q9H5V8|
|Mutated Sites Count:||132|
|Associated Pubmed ID Count||13|
|Affected Protein Function Sites Count:||5|