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CCL5

Basics

Aliases:
This biomarker is also known as:
  • T cell-specific protein P228,
  • RANTES,
  • MGC17164,
  • small inducible cytokine A5 (RANTES),
  • T-cell-specific protein RANTES,
  • C-C motif chemokine 5,
  • Small-inducible cytokine A5,
  • eosinophil chemotactic cytokine,
  • Eosinophil chemotactic cytokine,
  • T-cell specific protein p288,
  • SCYA5,
  • small inducible cytokine subfamily A (Cys-Cys), member 5,
  • TCP228,
  • eoCP,
  • SISd,
  • chemokine (C-C motif) ligand 5,
  • D17S136E,
  • regulated upon activation, normally T-expressed, and presumably secreted,
  • EoCP,
  • small-inducible cytokine A5,
  • SIS-delta,
  • beta-chemokine RANTES,
  • t cell-specific protein P228,

Description…

From NCBI Gene: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL5

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Curated

Overview

The chemokine CCL5 (RANTES), a major monocyte chemoattractant expressed by breast tumor cells, has been implicated in the progression of breast cancer.

Performance Comment

CCL5 (RANTES) was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: CCL5
UniProt Accession #: P13501
Mutated Sites Count: 12
Associated Pubmed ID Count 2
CancerDO Count 9
Affected Protein Function Sites Count: 4

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