CCL28
Basics
Aliases:
This biomarker is also known as:- small inducible cytokine A28,
- SCYA28,
- Protein CCK1,
- Mucosae-associated epithelial chemokine,
- CCK1,
- small-inducible cytokine A28,
- mucosae-associated epithelial chemokine,
- small inducible cytokine subfamily A (Cys-Cys), member 28,
- C-C motif chemokine 28,
- Small-inducible cytokine A28,
- CC chemokine CCL28,
- MEC,
- chemokine (C-C motif) ligand 28 splice variant chi,
- chemokine (C-C motif) ligand 28,
Description…
CCL28 is a member of the small cytokine CC subfamily, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two adjacent cysteines. CCL28 functions as a chemotactic factor for resting CD4 or CD8 T cells and eosinophils. CCL28 binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Attributes
QA State: | Curated |
---|---|
Type: | Protein |
Short Name: | |
HGNC Name: | CCL28 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
Phase: | Two |
---|---|
QA State: | Under Review |
Overview
CCL28 was present at higher levels among cases compared to controls with reasonable AUC values.
Performance Comment
CCL28 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.
- Longitudinal assessment of urinary PCA3 for predicting prostate cancer grade reclassification in favorable-risk men during active surveillance.
Resources
External Resources for CCL28
Gene
- HGNC entry for CCL28 from Genenames
- KEGG entry for CCL28 from Genome.jp
- Ensembl entry for CCL28
- Entrez entry for CCL28 all NCBI Databasese
- GWAS Study Datasets containing gene CCL28 from GWAS
- Find Human Single Nucleotide Polymorphisms info for CCL28
- Human Gene(s) with 'CCL28' as Gene Name/Alias
- Human RNA sequence for 'CCL28'
- GeneCards entry for human CCL28
Protein
- UniProtKB/Swiss-Prot entry for CCL28 from Uniprot
- Human Protein RefSeq for CCL28 from NCBI
- Pfam: Protein family information for CCL28
Other
No other associated resources found.
Biomuta
Mutation Statistics
Gene Name: | CCL28 |
---|---|
UniProt Accession #: | Q9NRJ3 |
Mutated Sites Count: | 15 |
Associated Pubmed ID Count | 3 |
CancerDO Count | 10 |
Affected Protein Function Sites Count: | 1 |