Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

 
You are here: Home / Biomarkers / CCL28

CCL28

Basics

Aliases:
This biomarker is also known as:
  • Mucosae-associated epithelial chemokine,
  • small-inducible cytokine A28,
  • CC chemokine CCL28,
  • CCK1,
  • SCYA28,
  • MEC,
  • small inducible cytokine subfamily A (Cys-Cys), member 28,
  • chemokine (C-C motif) ligand 28 splice variant chi,
  • Small-inducible cytokine A28,
  • small inducible cytokine A28,
  • C-C motif chemokine 28,
  • Protein CCK1,
  • chemokine (C-C motif) ligand 28,
  • mucosae-associated epithelial chemokine,

Description…

CCL28 is a member of the small cytokine CC subfamily, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two adjacent cysteines. CCL28 functions as a chemotactic factor for resting CD4 or CD8 T cells and eosinophils. CCL28 binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL28

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

CCL28 was present at higher levels among cases compared to controls with reasonable AUC values.

Performance Comment

CCL28 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

Resources

External Resources for CCL28

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: CCL28
UniProt Accession #: Q9NRJ3
Mutated Sites Count: 15
Associated Pubmed ID Count 3
CancerDO Count 10
Affected Protein Function Sites Count: 1

View in BioMuta