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CCL27

Basics

Aliases:
This biomarker is also known as:
  • ALP,
  • SCYA27,
  • CTACK,
  • Skinkine,
  • small-inducible cytokine A27,
  • small inducible cytokine subfamily A (Cys-Cys), member 27,
  • IL-11 Ralpha-locus chemokine,
  • C-C motif chemokine 27,
  • cutaneous T-cell attracting chemokine,
  • IL-11 R-alpha-locus chemokine,
  • cutaneous T-cell-attracting chemokine,
  • Cutaneous T-cell-attracting chemokine,
  • ESKINE,
  • Small-inducible cytokine A27,
  • chemokine (C-C motif) ligand 27,
  • ILC,
  • PESKY,
  • CTAK,
  • CC chemokine ILC,
  • skinkine,
  • ESkine,

Description…

CCL27 is a member of the CC cytokine family, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two adjacent cysteines. CCL27 functions as a chemotactic factor that attracts skin-associated memory T-lymphocytes. CCL27 may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27 binds specifically to chemokine receptor 10 (CCR10).

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL27

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

CCL27 was present at higher levels among cases compared to controls with reasonable AUC values.

Performance Comment

CCL27 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for CCL27

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: CCL27
UniProt Accession #: Q9Y4X3
Mutated Sites Count: 13
Associated Pubmed ID Count 3
CancerDO Count 10
Affected Protein Function Sites Count: 1

View in BioMuta