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CCL2

Basics

Aliases:
This biomarker is also known as:
  • monocyte chemoattractant protein 1,
  • SCYA2,
  • chemokine (C-C motif) ligand 2,
  • small inducible cytokine subfamily A (Cys-Cys), member 2,
  • C-C motif chemokine 2,
  • Monocyte chemotactic and activating factor,
  • SMC-CF,
  • monocyte secretory protein JE,
  • HC11,
  • MCAF,
  • GDCF-2,
  • small-inducible cytokine A2,
  • Monocyte secretory protein JE,
  • MCP1,
  • monocyte chemoattractant protein-1,
  • monocyte chemotactic protein 1,
  • monocyte chemotactic and activating factor,
  • HSMCR30,
  • MGC9434,
  • MCP-1,
  • small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je),
  • Small-inducible cytokine A2,
  • Monocyte chemotactic protein 1,
  • Monocyte chemoattractant protein 1,

Description…

From NCBI Gene: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL2

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

CCL2, also known as MCP-1, was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: CCL2
UniProt Accession #: P13500
Mutated Sites Count: 24
Associated Pubmed ID Count 4
CancerDO Count 16
Affected Protein Function Sites Count: 4

View in BioMuta