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This biomarker is also known as:
  • Small-inducible cytokine A18,
  • DC-CK1,
  • macrophage inflammatory protein 4,
  • Dendritic cell chemokine 1,
  • pulmonary and activation-regulated chemokine,
  • chemokine (C-C), dendritic,
  • Pulmonary and activation-regulated chemokine,
  • CC chemokine ligand 18,
  • PARC,
  • dendritic cell chemokine 1,
  • C-C motif chemokine 18,
  • CC chemokine PARC,
  • SCYA18,
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated),
  • Alternative macrophage activation-associated CC chemokine 1,
  • AMAC-1,
  • AMAC1,
  • alternative macrophage activation-associated CC chemokine 1,
  • Macrophage inflammatory protein 4,
  • small inducible cytokine A18,
  • DCCK1,
  • MIP-4,
  • MIP4,
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated,
  • CKb7,
  • small-inducible cytokine A18,


From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]


QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL18


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Curated


CCL18 has been described in the literature as a potential biomarker for ovarian, bladder, breast, and colorectal cancer. CCL18 has not been identified previously in serum as a lung cancer biomarker, but it was observed up-regulated in lung cancer in the aptamer proteomic technology study (Ostroff et al, 2010).

Performance Comment

CCL18, also known as MIP-4, is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.



Phase: One
QA State: Under Review


Performance Comment


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: CCL18
UniProt Accession #: P55774
Mutated Sites Count: 14
Associated Pubmed ID Count 6
CancerDO Count 9
Affected Protein Function Sites Count: 2

View in BioMuta