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This biomarker is also known as:
  • AMAC1,
  • Dendritic cell chemokine 1,
  • CC chemokine PARC,
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated),
  • PARC,
  • DCCK1,
  • CKb7,
  • small-inducible cytokine A18,
  • MIP4,
  • Alternative macrophage activation-associated CC chemokine 1,
  • dendritic cell chemokine 1,
  • alternative macrophage activation-associated CC chemokine 1,
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated,
  • chemokine (C-C), dendritic,
  • SCYA18,
  • pulmonary and activation-regulated chemokine,
  • Macrophage inflammatory protein 4,
  • Pulmonary and activation-regulated chemokine,
  • CC chemokine ligand 18,
  • MIP-4,
  • Small-inducible cytokine A18,
  • AMAC-1,
  • DC-CK1,
  • C-C motif chemokine 18,
  • macrophage inflammatory protein 4,
  • small inducible cytokine A18,


CCL18, also known as MIP-4, is a member of the cytokine family, a family of secreted proteins involved in immunoregulatory and inflammatory processes. CCL18 is a Cys-Cys (CC) cytokine, characterized by two adjacent cysteines. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL18


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Curated


CCL18 has been described in the literature as a potential biomarker for ovarian, bladder, breast, and colorectal cancer. CCL18 has not been identified previously in serum as a lung cancer biomarker, but it was observed up-regulated in lung cancer in the aptamer proteomic technology study (Ostroff et al, 2010).

Performance Comment

CCL18, also known as MIP-4, is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.



Phase: One
QA State: Under Review


Performance Comment


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: CCL18
UniProt Accession #: P55774
Mutated Sites Count: 13
Associated Pubmed ID Count 6
CancerDO Count 10
Affected Protein Function Sites Count: 4

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