Personal tools

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit

Updates regarding government operating status and resumption of normal operations can be found at

You are here: Home / Biomarkers / CCL18



This biomarker is also known as:
  • small-inducible cytokine A18,
  • DCCK1,
  • AMAC1,
  • AMAC-1,
  • DC-CK1,
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated),
  • alternative macrophage activation-associated CC chemokine 1,
  • pulmonary and activation-regulated chemokine,
  • Macrophage inflammatory protein 4,
  • Alternative macrophage activation-associated CC chemokine 1,
  • CC chemokine ligand 18,
  • CC chemokine PARC,
  • macrophage inflammatory protein 4,
  • chemokine (C-C), dendritic,
  • Small-inducible cytokine A18,
  • C-C motif chemokine 18,
  • SCYA18,
  • small inducible cytokine A18,
  • dendritic cell chemokine 1,
  • Pulmonary and activation-regulated chemokine,
  • PARC,
  • MIP-4,
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated,
  • CKb7,
  • Dendritic cell chemokine 1,
  • MIP4,


CCL18, also known as MIP-4, is a member of the cytokine family, a family of secreted proteins involved in immunoregulatory and inflammatory processes. CCL18 is a Cys-Cys (CC) cytokine, characterized by two adjacent cysteines. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL18


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Curated


CCL18 has been described in the literature as a potential biomarker for ovarian, bladder, breast, and colorectal cancer. CCL18 has not been identified previously in serum as a lung cancer biomarker, but it was observed up-regulated in lung cancer in the aptamer proteomic technology study (Ostroff et al, 2010).

Performance Comment

CCL18, also known as MIP-4, is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.



Phase: One
QA State: Under Review


Performance Comment


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: CCL18
UniProt Accession #: P55774
Mutated Sites Count: 14
Associated Pubmed ID Count 6
CancerDO Count 9
Affected Protein Function Sites Count: 2

View in BioMuta