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CCL18

Basics

Aliases:
This biomarker is also known as:
  • CC chemokine ligand 18,
  • SCYA18,
  • pulmonary and activation-regulated chemokine,
  • alternative macrophage activation-associated CC chemokine 1,
  • Pulmonary and activation-regulated chemokine,
  • DCCK1,
  • Small-inducible cytokine A18,
  • small inducible cytokine A18,
  • chemokine (C-C), dendritic,
  • dendritic cell chemokine 1,
  • CC chemokine PARC,
  • Alternative macrophage activation-associated CC chemokine 1,
  • Macrophage inflammatory protein 4,
  • MIP4,
  • MIP-4,
  • small-inducible cytokine A18,
  • DC-CK1,
  • AMAC-1,
  • AMAC1,
  • C-C motif chemokine 18,
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated),
  • PARC,
  • macrophage inflammatory protein 4,
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated,
  • Dendritic cell chemokine 1,
  • CKb7,

Description…

CCL18, also known as MIP-4, is a member of the cytokine family, a family of secreted proteins involved in immunoregulatory and inflammatory processes. CCL18 is a Cys-Cys (CC) cytokine, characterized by two adjacent cysteines. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: CCL18

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Two
QA State: Curated

Overview

CCL18 has been described in the literature as a potential biomarker for ovarian, bladder, breast, and colorectal cancer. CCL18 has not been identified previously in serum as a lung cancer biomarker, but it was observed up-regulated in lung cancer in the aptamer proteomic technology study (Ostroff et al, 2010).

Performance Comment

CCL18, also known as MIP-4, is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: CCL18
UniProt Accession #: P55774
Mutated Sites Count: 13
Associated Pubmed ID Count 6
CancerDO Count 10
Affected Protein Function Sites Count: 4

View in BioMuta