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BCAM

Basics

Aliases:
This biomarker is also known as:
  • B-CAM cell surface glycoprotein,
  • Lutheran antigen,
  • Basal cell adhesion molecule,
  • F8/G253 antigen,
  • LU,
  • AU,
  • Lutheran blood group glycoprotein,
  • basal cell adhesion molecule (Lutheran blood group),
  • basal cell adhesion molecule (Lu and Au blood groups),
  • Lutheran blood group (Auberger b antigen included),
  • CD_antigen=CD239,
  • CD239,
  • Auberger B antigen,
  • MSK19,

Description…

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin alpha-5. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. It may also play a role in intracellular signalling. BCAM has wide tissue distribution (highest in the pancreas and very low in brain) and is closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. Two transcript variants encoding different isoforms have been found for this gene.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: BCAM

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Three
QA State: Curated

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for BCAM


Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: BCAM
UniProt Accession #: P50895
Mutated Sites Count: 95
Associated Pubmed ID Count 15
CancerDO Count 23
Affected Protein Function Sites Count: 2

View in BioMuta

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