Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / ATP6V1G1

ATP6V1G1

Basics

Aliases:
This biomarker is also known as:
  • V-ATPase 13 kDa subunit 1,
  • vacuolar proton pump subunit M16,
  • vacuolar H(+)-ATPase subunit G 1,
  • Vacuolar proton pump subunit M16,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1,
  • ATP6G,
  • Vma10,
  • vacuolar proton pump subunit G 1,
  • ATP6G1,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J,
  • DKFZp547P234,
  • V-ATPase subunit G 1,
  • V-type proton ATPase subunit G 1,
  • vacuolar ATP synthase subunit M16,
  • Vacuolar proton pump subunit G 1,
  • ATP6J,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1,
  • ATP6GL,

View in BioMuta

Description…

ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ATP6V1G1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

ATP6V1G1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement