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ANO1

Basics

Aliases:
This biomarker is also known as:
  • tumor-amplified and overexpressed sequence 2,
  • transmembrane protein 16A,
  • Transmembrane protein 16A,
  • Tumor-amplified and overexpressed sequence 2,
  • transmembrane protein 16A (eight membrane-spanning domains),
  • Discovered on gastrointestinal stromal tumors protein 1,
  • FLJ10261,
  • Oral cancer overexpressed protein 2,
  • anoctamin 1, calcium activated chloride channel,
  • TMEM16A,
  • oral cancer overexpressed 2,
  • discovered on gastrointestinal stromal tumors protein 1,
  • TAOS2,
  • anoctamin-1,
  • DOG1,
  • ORAOV2,

Description…

ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ANO1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

ANO1 is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer. ANO1 is amplified and highly expressed in breast cancer cell lines and primary tumors.

Performance Comment

ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: ANO1
UniProt Accession #: Q5XXA6
Mutated Sites Count: 158
Associated Pubmed ID Count 13
CancerDO Count 23
Affected Protein Function Sites Count: 4

View in BioMuta