Aliases:This biomarker is also known as:
- transmembrane protein 16A,
- transmembrane protein 16A (eight membrane-spanning domains),
- oral cancer overexpressed 2,
- anoctamin 1, calcium activated chloride channel,
- Tumor-amplified and overexpressed sequence 2,
- tumor-amplified and overexpressed sequence 2,
- Transmembrane protein 16A,
- Oral cancer overexpressed protein 2,
- discovered on gastrointestinal stromal tumors protein 1,
- Discovered on gastrointestinal stromal tumors protein 1,
ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
ANO1 is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer. ANO1 is amplified and highly expressed in breast cancer cell lines and primary tumors.
ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
|UniProt Accession #:||Q5XXA6|
|Mutated Sites Count:||158|
|Associated Pubmed ID Count||13|
|Affected Protein Function Sites Count:||4|