Aliases:This biomarker is also known as:
- alpha-methylacyl-CoA racemase,
- 2-methylacyl-CoA racemase,
AMACR, a racemase, is an enzyme that interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from the gene locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Frequent overexpression of AMACR has been detected in prostate cancer tumors.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
AMACR is overexpressed in prostate cancer and may be useful in the interpretation of prostate needle biopsy specimens that are diagnostically challenging.
Increased AMACR transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.
|UniProt Accession #:||Q9UHK6|
|Mutated Sites Count:||55|
|Associated Pubmed ID Count||9|
|Affected Protein Function Sites Count:||5|