Aliases:This biomarker is also known as:
- ADAM 12,
- disintegrin and metalloproteinase domain-containing protein 12,
- EC 3.4.24.-,
- a disintegrin and metalloproteinase domain 12 (meltrin alpha),
- ADAM metallopeptidase domain 12,
ADAM12 is a member of the ADAM (a disintegrin and metalloprotease) protein family. ADAM family members are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions. ADAM12 has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
ADAM12 is a transmembrane tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.
ADAM12 is very highly expressed in some epithelial ovarian cancer samples compared with normal ovaries but a significant number of cancer samples exhibited low levels of ADAM12. Thus, ADAM12 may hold predictive value, and it could be used for therapy, especially the long isoform, for patients whose tumors express it.
- HGNC entry for ADAM12 from Genenames
- KEGG entry for ADAM12 from Genome.jp
- Entrez entry for ADAM12 all NCBI Databasese
- Human GEO Profiles for ADAM12 from NCBI GEO Profiles
- Human Geo Datasets containing term ADAM12 from NCBI GEO Datasets
- GWAS Study Datasets containing gene ADAM12 from GWAS
- Human Single Nucleotide Polymorphisms info for ADAM12
- Human Gene(s) with 'ADAM12' as Gene Name/Alias
- Human Gene RefSeq for ADAM12 from NCBI
- GeneCards entry for human ADAM12
- UniProtKB/Swiss-Prot entry for ADAM12 from Uniprot
- Human Protein RefSeq for ADAM12 from NCBI
- FDA web page describing approval of ADAM12
|UniProt Accession #:||O43184|
|Mutated Sites Count:||301|
|Associated Pubmed ID Count||31|
|Affected Protein Function Sites Count:||5|