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ACTR3

Basics

Aliases:
This biomarker is also known as:
  • P61158,
  • actin-like protein 3,
  • ARP3 actin-related protein 3 homolog (yeast),
  • Actin-like protein 3,
  • ARP3,
  • actin-related protein 3,
  • ARP3 (actin-related protein 3, yeast) homolog,

Description…

The ACTR3 protein is a component of the ARP2/3 complex, which is essential to cell shape and motility.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ACTR3

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

ACTR3 is a tumor vascular marker (TVM) identified through expression profiling of ovarian cancer vascular cells.

Performance Comment

In PMID:21617380, 13 tumor vascular markers (TVMs) from 50 candidates identified through expression profiling of ovarian cancer vascular cells and selected to be either transmembrane or secreted, and to be either absent or expressed at low levels in normal tissues while overexpressed in tumors, based on analysis of 1,110 normal and tumor tissues from publicly available Affymetrix microarray data were investigated. ACTR3 was not selected to be studied further.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for ACTR3

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: ACTR3
UniProt Accession #: P61158
Mutated Sites Count: 40
Associated Pubmed ID Count 7
CancerDO Count 19
Affected Protein Function Sites Count: 5

View in BioMuta