Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / ACO1

ACO1

Basics

Aliases:
This biomarker is also known as:
  • ferritin repressor protein,
  • iron-responsive element binding protein 1,
  • IREBP1,
  • IRP1,
  • Iron-responsive element-binding protein 1,
  • iron-responsive element-binding protein 1,
  • IREB1,
  • IRE-BP 1,
  • Citrate hydro-lyase,
  • iron regulatory protein 1,
  • citrate hydro-lyase,
  • ACONS,
  • Ferritin repressor protein,
  • aconitase 1, soluble,
  • cytoplasmic aconitate hydratase,
  • Iron regulatory protein 1,
  • EC 4.2.1.3,
  • Aconitase,
  • IREBP,
  • aconitate hydratase,

Description…

aconitase 1, soluble

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: ACO1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

This gene is part of a 114-gene set that comprises a stroma-specific classifier for nearby prostate tumors. Gene expression changes in stroma have been identified that can detect tumor nearby. This classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. (PMID:21459804)

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for ACO1


Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: ACO1
UniProt Accession #: P21399
Mutated Sites Count: 97
Associated Pubmed ID Count 10
CancerDO Count 20
Affected Protein Function Sites Count: 5

View in BioMuta