Aliases:This biomarker is also known as:
- G-protein coupled receptor RDC1 homolog,
- chemokine orphan receptor 1,
- Chemokine orphan receptor 1,
- G-protein coupled receptor 159,
- chemokine (C-X-C motif) receptor 7,
- C-X-C chemokine receptor type 7,
- G protein-coupled receptor,
ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. ACKR3 is also a coreceptor for human immunodeficiency viruses (HIV).
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional ovarian data available.
ACKR3 (CXCR7, CMKOR1) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. ACKR3 (CXCR7, CMKOR1) was not in the group of 13 selected for further validation.
- HGNC entry for ACKR3 from Genenames
- KEGG entry for ACKR3 from Genome.jp
- Entrez entry for ACKR3 all NCBI Databasese
- Human GEO Profiles for ACKR3 from NCBI GEO Profiles
- Human Geo Datasets containing term ACKR3 from NCBI GEO Datasets
- GWAS Study Datasets containing gene ACKR3 from GWAS
- Human Single Nucleotide Polymorphisms info for ACKR3
- Human Gene(s) with 'ACKR3' as Gene Name/Alias
- Human Gene RefSeq for ACKR3 from NCBI
- GeneCards entry for human ACKR3
- UniProtKB/Swiss-Prot entry for ACKR3 from Uniprot
- Human Protein RefSeq for ACKR3 from NCBI
- FDA web page describing approval of ACKR3
|UniProt Accession #:||P25106|
|Mutated Sites Count:||100|
|Associated Pubmed ID Count||11|
|Affected Protein Function Sites Count:||4|