Prostate and Urologic Cancers Research Group

Semmes, John
Sanda, Martin
4k score
14 SNPs
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
ACO1
From NCBI Gene: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with …
ACP3
From NCBI Gene: This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under …
ACSL3
acyl-CoA synthetase long-chain family member 3
ACTC1
actin, alpha, cardiac muscle 1
ACY1
aminoacylase 1
AGR2
From NCBI Gene: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and …
AGTPBP1
From NCBI Gene: NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from …
AHNAK2
AHNAK nucleoprotein 2
ALDH1A2
From NCBI Gene: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of …
AMACR
AMACR, a racemase, is an enzyme that interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the …
AMD1
adenosylmethionine decarboxylase 1
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
ANG
Angiogenin, or ANG, is a mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to …
ANKRD40
ankyrin repeat domain 40
ANXA2
From NCBI Gene: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the …
ANXA3
annexin A3
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
APC
The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell …
APOE
From NCBI Gene: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is …
APOLD1
From NCBI Gene: APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function …
ARHGDIA
From NCBI Gene: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the …
ARHGEF40
From NCBI Gene: This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a …
ARID5A
From NCBI Gene: Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, …
ARLNC1
Androgen receptor regulated long noncoding RNA 1 is a noncoding RNA, belonging to the long noncoding class.
ATF3
From NCBI Gene: This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of …
AUH
From NCBI Gene: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a …
AZGP1
From NCBI Gene: Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. …
BCHE
From NCBI Gene: This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits …
BCL2L14
From NCBI Gene: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or …
BDNF
From NCBI Gene: This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at …
BHMT2
From NCBI Gene: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to …
BIN1
From NCBI Gene: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein …
BPSA
From PMID:18550118: A degraded form of PSA with internal peptide bond cleavages associated with benign prostatic hyperplasia and the transition zone of the …
BTN2A1
From NCBI Gene: This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the …
C1QBP
From NCBI Gene: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The …
C6orf62
From GeneCards: C6orf62 (Chromosome 6 Open Reading Frame 62) is a Protein Coding gene.
C7
From NCBI Gene: This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of …
CA9
From NCBI Gene: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate …
CA15-3
From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role …
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker …
CALR
From NCBI Gene: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It …
CAMKK2
From NCBI Gene: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase …
CAND2
From NCBI Gene: Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of transcription, …
CAV1
From NCBI Gene: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links …
CAVIN1
From NCBI Gene: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA …
CAVIN2
From NCBI Gene: This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a …
CBX4
From UniprotKB/Swiss-Prot: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a …
CCDC69
From NCBI Gene: Predicted to enable microtubule binding activity. Involved in spindle midzone assembly. Located in spindle midzone. [provided by Alliance of …
CCDC91
From NCBI Gene: Predicted to enable identical protein binding activity. Involved in Golgi to lysosome transport. Located in nucleoplasm and trans-Golgi …
CCL18
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of …
CCL20
From NCBI Gene: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in …
CCNA1
From NCBI Gene: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in …
CCNG2
From NCBI Gene: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. …
CD2AP
From NCBI Gene: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a …
CD24
From NCBI Gene: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to …
CD164
From NCBI Gene: This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of …
CD177
From NCBI Gene: his gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein …
CDC42EP3
From NCBI Gene: This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive …
CDH1
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein …
CDK7
From NCBI Gene: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the …
CDK16
From NCBI Gene: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal …
CDKN1A
From NCBI Gene: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent …
CDKN1C
From NCBI Gene: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of …
CDKN2A (p16)
From NCBI Gene: This gene (CDKN2A) generates several transcript variants which differ in their first exons. At least three alternatively spliced variants …
CDKN2C
From NCBI Gene: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact …
CEACAM1
From NCBI Gene: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of …
CEACAM5
From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the …
CEBPD
From NCBI Gene: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It …
CFB
From NCBI Gene: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a …
Chinnaiyan (Laxman) 7 marker panel for prostate cancer
This 7-marker multiplex panel of urine transcripts outperforms PCA3 transcript alone for the detection of prostate cancer. The panel consists of PCA3, AMACR, …
CHN2
From NCBI Gene: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a …
CLDN8
From NCBI Gene: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight …
CLIP3
From NCBI Gene: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated …
COL4A2
From NCBI Gene: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of …
CP
From NCBI Gene: The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of …
CPB1
From NCBI Gene: Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other …
CPM
From NCBI Gene: he protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage …
CPQ
From NCBI Gene: This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with …
CRTAC1
CRTAC1, a secreted protein, is expressed in the interterritorial matrix of articular deep zone cartilage. There are three isoforms for CRTAC1; isoform 1, …
CRTC3
From NCBI Gene: This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a …
CSDC2
From NCBI Gene: Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in nucleus. …
CSGALNACT1
From NCBI Gene: This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin …
CSNK2A1
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, …
CSPG4
From NCBI Gene: A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of …
CTIF
From NCBI Gene: CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to …
CXADR
From NCBI Gene: The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript …
CXCL1
From NCBI Gene: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals …
CXCL2
From NCBI Gene: This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory …
CXCL5
From NCBI Gene: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are …
CXCL8
From NCBI Gene: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded …
CYP1B1
From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many …
D4S243
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D9S171
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D9S747
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D9SS162
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D16S310
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D16S476
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D17S654
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D17S695
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D20S48
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
D21S1245
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
DAAM2
From NCBI Gene: Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in nervous system development and …
DBN1
From NCBI Gene: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a …
DGLUCY
From NCBI Gene: Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Predicted to be located in …
DLG3
From NCBI Gene: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of …
DMPK
From NCBI Gene: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho …
DMWD
DMWD is a protein coding gene that is expressed in testis, brain, and 25 other tissues. It is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. …
DMXL1
From NCBI Gene: The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed …
DNAJB6
From NCBI Gene: This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called …
DNAJC3
From NCBI Gene: This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ …
DNAJC15
From UniProtKB/Swiss-Prot: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts …
DPP4
From NCBI Gene: The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an …
DPYSL3
From NCBI Gene: Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma …
DSC2
DSC2, a calcium-dependent glycoprotein, is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the …
DSG2
From NCBI Gene: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are …
DUSP22
From NCIB Gene: Enables non-membrane spanning protein tyrosine phosphatase activity and protein tyrosine kinase binding activity. Involved in several …
DYSF
From NCBI Gene: The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is …
EAF2
From UniProtKB/Swiss-Prot: Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of …
EFCAB14
From NCBI Gene: Predicted to enable calcium ion binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, …
EFEMP1
From NCBI Gene: This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein …
EGFR
From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor …
EHF
From NCBI Gene: This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The …
EIF5A
From UniProtKB/Swiss-Prot: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting …
ELF5
From NCBI Gene: The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role …
ELOVL2
From UniProtKB/Swiss-Prot: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This …
ENO2
From NCBI Gene: This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of …
ENTPD5
From NCBI Gene: The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism …
EPCA-2
Early prostate cancer antigen-2 (EPCA-2) is a protein of which blood levels are elevated in prostate cancer. EPCA-2 is not the name of a gene.
EPM2A
From NCBI Gene: This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex …
ERBB3
From NCBI Gene: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has …
ERG
The ERG gene codes for the ERG protein, a transcription factor that is a member of the erythroblast transformation-specific (ETS) family of transcriptions …
EXOSC2
From UniProtKB/Swiss-Prot: Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of …
FADS2
From NCBI Gene: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty …
FAIM2
From NCBI Gene: Involved in regulation of neuron apoptotic process. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via …
FAM131B
From NCBI Gene: Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
FAM234B
From NCBI Gene: Predicted to be located in Golgi apparatus and cytoskeleton. Predicted to be integral component of membrane. [provided by Alliance of Genome …
FBLN1
From NCBI Gene: Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to …
FBXO9
From NCBI Gene: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box …
FCER1A
From NCBI Gene: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are …
FERMT2
From NCBI Gene: Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming …
FEZ1
From NCBI Gene: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. …
FGA
From NCBI Gene: This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, …
FHL1
From NCBI Gene: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc …
FHL3
From NCBI Gene: The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved …
FHOD3
From NCBI Gene: The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD …
FKBP11
From NCBI Gene: FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The …
FLNA
From NCBI Gene: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane …
FLNC
From NCBI Gene: This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into …
FMO5
From NCBI Gene: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an …
FOLH1
From NCBI Gene: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase …
FOLH1B
FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related to …
FOXD1
From NCBI Gene: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the …
fPSA
Free PSA circulates in the bloodstream unbound to any proteins. It is measured separately from PSA and from proPSA, which is also known as [-2]proPSA.
FTH1P5
FTH1P5 (Ferritin heavy chain 1 pseudogene 5) is a pseudogene.
FXYD6
From NCBI Gene: This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects …
G3BP1
From NCBI Gene: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and …
GADD45A
From NCBI Gene: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with …
GADD45B
From NCBI Gene: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with …
GALNT3
From NCBI Gene: This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the …
GALNT7
From NCBI Gene: This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step …
Garcia chromosomal aneusomy + cytology
Fluorescence in situ hybridization (FISH) assay is used to monitor levels of chromosome copies in interphase cells. Multicolor FISH proes simultaneously …
GEM
From NCBI Gene: The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma …
Genomic Health Index Score
From oncotypeiq.com: The Oncotype DX Genomic Prostate Score (GPS) assay is the only genomic assay designed for men with clinically low-risk or favorable …
Germline Progression
Germline Upgrading
GGT1
From NCBI Gene: The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a …
GLDC
From NCBI Gene: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein …
GLRX
From NCBI Gene: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of …
GLUD1
From NCBI Gene: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to …
GNB5
From NCBI Gene: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed …
GP73
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi transmembrane …
GPM6B
GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is …
GPNMB
From NCBI Gene: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific …
GSTA1
From NCBI Gene: This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, …
GSTP1
Glutathione S-transferases are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and …
H1-2
This gene was formerly known as HIST1H1C. From NCBI Gene: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in …
H2BC4
This gene was formerly known as HIST1H2BC. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the …
H2BC6
This gene was formerly known as HIST1H2BE. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the …
H2BC7
This gene was formerly known as HIST1H2BF. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the …
H2BC8
This gene was formerly known as HIST1H2BG. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the …
H2BC9
This gene was formerly known as HIST1H2BH. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the …
H2BC10
This gene was formerly known as HIST1H2BI. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the …
HLA-G
From NCBI Gene: HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain …
HNRNPD
From NCBI Gene: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid …
HNRNPL
From NCBI Gene: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous …
HOXA4
From NCBI Gene: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four …
HOXA5
From NCBI Gene: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four …
HOXA9
From NCBI Gene: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four …
HOXB13
From NCBI Gene: This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates …
HPD
From NCBI Gene: The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of …
HPGD
From NCBI Gene: This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the …
HSP90B1
From NCBI Gene: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding …
HSPA12A
From NCBI Gene: Predicted to enable ATP binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2021]
HSPB1
From NCBI Gene: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein …
HSPB6
From NCBI Gene: This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
HSPB8
From NCBI Gene: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at …
IFNA1
From NCBI Gene: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family …
IGF1
From NCBI Gene: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating …
IGFBP6
From NCBI Gene: Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive …
IHC and FISH for T2-ERG fusion
IHC and FISH for T2-ERG fusion.
IQCB1
From NCBI Gene: This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded …
IRF9
From NCBI Gene: This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including …
ITGA5
From NCBI Gene: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an …
ITGB3
From NCBI Gene: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta …
JAG1
From NCBI Gene: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor …
JMJD6
From NCBI Gene: This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or …
KCNJ8
From NCBI Gene: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by …
KCTD17
From NCBI Gene: This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The …
KIF3C
From NCBI Gene: Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. …
KLC1
From NCBI Gene: Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along …
KLF5
From NCBI Gene: This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator …
KLK2
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. The glandular kallikrein gene family comprises 25 …
KLK4
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases …
KLK11
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases …
KPNA6
From NCBI Gene: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear …
KRT7
From NCBI Gene: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which …
KRT19
KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. …
L1CAM
From NCBI Gene: The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of …
LARP6
From NCBI Gene: Enables RNA binding activity and myosin binding activity. Involved in positive regulation of collagen biosynthetic process; positive regulation …
LCN2
From NCBI Gene: This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, …
LCP1
From NCBI Gene: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher …
LDAH
Previously known as C2orf43, the protein product of this gene is lipid droplet associated hydrolase. From UniprotKB/SwissProt: Serine lipid hydrolase …
LEPR
From NCBI Gene: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via …
LGALS8
From NCBI Gene: This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate …
LIMS2
From NCBI Gene: This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which …
LMNA
From NCBI Gene: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins …
LMO3
From NCBI Gene: The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in …
LMOD1
From NCBI Gene: The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all …
LPIN1
From NCBI Gene: This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride …
LTBP4
From NCBI Gene: The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB …
LTF
From NCBI Gene: This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein …
LYPLA1
From NCBI Gene: This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both …
MAL
From NCBI Gene: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has …
MAOB
From NCBI Gene: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It …
MAP1A
From NCBI Gene: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved …
MAZ
From NCBI Gene: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA …
MBP
From NCBI Gene: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous …
MBPA
Microsatellites are tandem repeat DNA sequences that are common, highly polymorphic genetic elements within the eukaryotic genome. Alterations, either …
MCAM
From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its …
MCCC2
From NCBI Gene: This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation …
MCUR1
From UniprotKB/Swiss-Prot: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, …
ME1
From NCBI Gene: This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the …
MED21
From NCBI Gene: This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme …
Mercola 7-gene signature for prostate cancer
Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, …
MFAP5
From NCBI Gene: This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded …
MGMT
From NCBI Gene: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair …
Microsatellite Instability Assay
Microsatellite analysis (MSA) is a promising new technique for the surveillance of bladder cancer. The technology, which permits the separation by …
MiPS (Mi Prostate Score Urine test)
The MiPS assay is a multiplex analysis of T2-ERG gene fusion, PCA3, and serum PSA (KLK3). It is commercially available through the University of Michigan …
Mitochondrial Genome Deletion for Detection of Prostate Cancer
The Prostate Core Mitomic Test is based upon a 3.4 kb mitochondrial genome deletion (3.4 mtdelta) that was identified through PCR analysis of frozen prostate …
MKI67
From NCBI Gene: This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript …
MLX
From NCBI Gene: The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form …
MMP9
MMP9 is a member of the matrix metalloproteinase (MMP) family. It is a secreted protein that may play an essential role in local proteolysis of the …
MMP10
From NCBI Gene: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the …
MMP28
From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological …
MMRN2
From NCBI Gene: This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an …
MPPED2
From NCBI Gene: This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript …
MPZ
From NCBI Gene: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a …
MPZL2
From NCBI Gene: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like …
MSRA
From NCBI Gene: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. …
MSX2
From NCBI Gene: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity …
MTA1
From NCBI Gene: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell …
MTMR11
From NCBI Gene: Predicted to enable phosphatidylinositol-3-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Located in …
MTO1
From NCBI Gene: This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role …
MXRA7
From NCBI Gene: Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
MZT2A
From NCBI Gene: Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
NCOA2
From NCBI Gene: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, …
NCS1
From NCBI Gene: This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The …
NEK3
From NCBI Gene: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other …
NKX3-1
From NCBI Gene: This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell …
NLRP1
From NCBI Gene: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are …
NR4A1
From NCBI Gene: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human …
NR4A3
From NCBI Gene: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional …
NRIP2
From NCBI Gene: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch …
NRXN1
From NCBI Gene: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind …
NT5E
From NCBI Gene: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable …
NXN
From NCBI Gene: This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are …
NXPE4
From NCBI Gene: Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2021]
NXT1
From NCBI Gene: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein …
OAS1
From NCBI Gene: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase …
OGT
From NCBI Gene: This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or …
OPA1
From NCBI Gene: The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein …
ORM1
From NCBI Gene: This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an …
OSBPL10
From NCBI Gene: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the …
p14/ARF
From NCBI Gene: This gene (CDKN2A) generates several transcript variants which differ in their first exons. At least three alternatively spliced variants …
PCA3
The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. Because there is no extensive open reading frame, the …
PCAT1
From NCBI Gene: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This …
PCAT14
Prostate Cancer Associated Transcript 14 is a noncoding RNA, belonging to the long noncoding class.
PCAT29
From NCBI Gene: This gene is thought to produce a functional long non-coding RNA. This transcript was identified in prostate cancer cells and may suppress …
PCGEM1
From NCBI Gene: This gene produces a long non-coding RNA that is overexpressed in prostate cancer and may act a marker for tumor progression. This RNA may act …
PDCD4
From NCBI Gene: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function …
PDCD10
From NCBI Gene: This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein …
PDLIM4
From NCBI Gene: This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to …
PDLIM5
From NCBI Gene: This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at …
PDLIM7
From NCBI Gene: The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed …
PDZK1IP1
From NCBI Gene: Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2021]
PER1
From NCBI Gene: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary …
PERP
From NCBI Gene: Involved in activation of cysteine-type endopeptidase activity. Predicted to be located in plasma membrane. Predicted to be active in cell-cell …
PGC
From NCBI Gene: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in …
phi/PCA3
Prostate Health Index (phi or PHI) and Prostate Cancer Antigen 3.
PLA2G2A
From NCBI Gene: The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect …
PLN
From NCBI Gene: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The …
PLP1
From NCBI Gene: This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the …
PLPP2
From NCBI Gene: The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to …
PNISR
From NCBI Gene: Enables RNA binding activity. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
PPIF
From NCBI Gene: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans …
PQBP1
From NCBI Gene: This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW …
PRMT5
From NCBI Gene: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the …
PRNCR1
PRNCR1 is a long non-coding RNA
PROM1
From NCBI Gene: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem …
proPSA
ProPSA (-2), or [-2]proPSA, is a PSA isoform which has a leader peptide (-2) amino acids at its N terminal region and does not interact with ACT or …
Prostate biomarkers (unspecified set 1)
Prostate biomarkers (unspecified set 2)
Protein mass location
SELDI instrument synchronization.
Proteomics pattern
PRPH
From NCBI Gene: This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate …
PRR4
From NCBI Gene: This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in …
PSA
KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily …
PSCA
From NCBI Gene: This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it …
PSD3
From NCBI Gene: Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF …
PTGDS
From NCBI Gene: The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) …
PTPRF
From NCBI Gene: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that …
RAB3B
From NCBI Gene: Enables GDP binding activity; GTPase activity; and myosin V binding activity. Involved in several processes, including positive regulation of …
RAB33B
From NCBI Gene: This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion …
RABEP1
From NCBI Gene: Enables protein domain specific binding activity and protein homodimerization activity. Involved in vesicle-mediated transport. Located in …
RARRES1
From NCBI Gene: This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is …
RASSF1
From NCBI Gene: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the …
RBBP4
From NCBI Gene: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present …
RBPMS
From NCBI Gene: This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids …
RDH11
From NCBI Gene: The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no …
RDH16
From NCBI Gene: Enables NAD-retinol dehydrogenase activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. …
REEP1
From NCBI Gene: This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene …
RET
From NCBI Gene: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial …
RHOQ
From NCBI Gene: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function …
RNF208
From NCBI Gene: Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by …
RPL13
From NCBI Gene: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are …
RPRM
From NCBI Gene: Predicted to be involved in regulation of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be …
RRAGD
From NCBI Gene: RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in …
RRAS2
From NCBI Gene: This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may …
RXRG
From NCBI Gene: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative …
S100B
From NCBI Gene: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are …
S100P
From NCBI Gene: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are …
SC5D
From NCBI Gene: This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. …
SCARA3
From NCBI Gene: This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play …
SCD
From NCBI Gene: This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid …
SCGB2A1
SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is …
SCHLAP1
SCHLAP1 (SWI/SNF Complex Antagonist Associated With Prostate Cancer 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with …
SCNN1A
From NCBI Gene: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels …
SDC1
SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The SDC1 protein functions as an integral …
SEL1L3
From NCBI Gene: Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
SERINC2
From NCBI Gene: Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine …
SERP1
From NCBI Gene: Predicted to be involved in endoplasmic reticulum unfolded protein response and protein glycosylation. Predicted to act upstream of or within …
SERPINA1
Alpha-1-antitrypsin is secreted and is an extracellular serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and …
SERPINE1
The SERPINE1 protein is a serine proteinase inhibitor (serpin) superfamily. SERPINE1 is the main inhibitor of tissue plasminogen activator (tPA) and urokinase …
SGCA
From NCBI Gene: This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to …
SLC2A3
From NCBI Gene: Enables dehydroascorbic acid transmembrane transporter activity; glucose binding activity; and glucose transmembrane transporter activity. …
SLC4A1AP
From GeneCards: SLC4A1AP (Solute Carrier Family 4 Member 1 Adaptor Protein) is a protein coding gene.
SLC4A4
From NCBI Gene: This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular …
SLC5A1
From NCBI Gene: This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary …
SLC5A7
From NCBI Gene: This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis …
SLC6A14
From NCBI Gene: This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter …
SLC9A3R2
From NCBI Gene: This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and …
SLC11A2
From NCBI Gene: This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved …
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
SLC22A3
From NCBI Gene: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous …
SLC26A2
From NCBI Gene: The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human …
SLC26A4
From NCBI Gene: Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is …
SLC34A2
From NCBI Gene: The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects …
SLC35C2
From NCBI Gene: This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic …
SLC39A6
From NCBI Gene: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as …
SLK
From NCBI Gene: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic …
SLPI
From NCBI Gene: This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including …
SNPs
SOCS3
From NCBI Gene: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family …
SOX10
From NCBI Gene: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development …
SPACA9
From NCBI Gene: Predicted to enable calcium-dependent protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, …
SPARC
From NCBI Gene: This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become …
SPINK1
SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Its physiological function is to prevent the …
SQOR
From NCBI Gene: The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic …
SRD5A3
From NCBI Gene: The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the …
SRP72
From NCBI Gene: This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of …
SRSF8
From NCBI Gene: This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal …
ST5
From NCBI Gene: This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a …
ST14
ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this …
STAT1
From NCBI Gene: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are …
STAT2
From NCBI Gene: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are …
STBD1
From NCBI Gene: Enables enzyme binding activity and glycogen binding activity. Involved in glycophagy and intracellular transport. Located in T-tubule; …
STEAP4
From NCBI Gene: The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi …
STK38L
From NCBI Gene: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal …
STOM
STOM, or stomatin, is an integral membrane protein located in the cell membrane of red blood cells and other cell types, where it is thought to regulate ion …
STT3A
From NCBI Gene: The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic …
STYXL1
From NCBI Gene: Enables protein phosphatase binding activity; protein phosphatase inhibitor activity; and pseudophosphatase activity. Involved in several …
SULT2B1
From NCBI Gene: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic …
SUSD5
From NCBI Gene: Predicted to enable hyaluronic acid binding activity. Predicted to be involved in Notch signaling pathway. Predicted to be integral component …
SVIL
From NCBI Gene: This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization …
SYDE1
From NCBI Gene: The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in …
SYNE3
From NCBI Gene: Enables actin filament binding activity and cytoskeleton-nuclear membrane anchor activity. Involved in cytoskeleton organization; establishment …
SYNGR1
From NCBI Gene: This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is …
TBXA2R
From NCBI Gene: This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation …
TCEAL2
From NCBI Gene: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains …
TCF21
From NCBI Gene: TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic …
Testosterone
From NCI Thesaurus: A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, …
TF
TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene duplication …
TFE3
From NCBI Gene: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of …
TFF3
TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at …
TGFB1
From NCBI Gene: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind …
TGFB1I1
From NCBI Gene: This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male …
TGM4
From NCBI Gene: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act …
THBS1
TSP is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP can bind to fibrinogen, fibronectin, laminin, type V collagen …
THOC1
From NCBI Gene: HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM …
THORLNC
Testis associated oncogenic lncRNA is a noncoding RNA, belonging to the long noncoding class.
THRA
From NCBI Gene: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, …
THY1
From NCBI Gene: This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell …
TMBIM6
From NCBI Gene: Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative …
TMEM30B
From NCBI Gene: Enables aminophospholipid flippase activity. Involved in aminophospholipid transport and positive regulation of protein exit from endoplasmic …
TMEM251
From NCBI Gene: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
TMPRSS2
TMPRSS2 is a member of the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. This gene was …
TMPRSS2:ERG
TMPRSS2:ERG gene fusions are a common genetic event in prostate cancer. These fusions are specific for prostate cancer and have also been observed in …
TMSB15A
From NCBI Gene: Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. …
TNFSF10
From NCBI Gene: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially …
TNFSF12
From NCBI Gene: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the …
TNS1
From NCBI Gene: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular …
TOM1L1
From NCBI Gene: Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive …
TOX4
From NCBI Gene: Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in …
TP53
TP53, also widely known as p53, acts as a tumor suppressor in many tumor types, responding to diverse cellular stresses to regulate target genes that induce …
TP63
TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many …
TPD52
From NCBI Gene: Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic …
TPD52L1
From NCBI Gene: This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is …
TRADD
From NCBI Gene: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell …
TRAF3IP2
From NCBI Gene: This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These …
TRAM1
From NCBI Gene: This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences …
TRIM22
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, …
TRIM27
From NCBI Gene: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 …
TRMT11
From NCBI Gene: Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be active in …
TRPC3
From NCBI Gene: The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The …
TSPAN2
From NCBI Gene: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members …
TSPAN6
From NCBI Gene: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members …
TSPAN8
From NCBI Gene: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members …
TSPAN13
From NCBI Gene: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members …
TUBA1A
From NCBI Gene: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta …
TUBB2B
From NCBI Gene: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly …
TUBB6
From NCBI Gene: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule …
UBE2D2
From NCBI Gene: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An …
UBE2J1
From NCBI Gene: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. …
Urine miRNA Progression
Urine Proteomics AS Upgrading
Urine Proteomics Diagnosis
Urine Proteomics Progression
Urine Proteomics Risk Stratification
Urine Proteomics Upgrading
VAMP4
From NCBI Gene: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in …
VAMP8
From NCBI Gene: This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble …
VEGFA
Vascular endothelial growth factor (VEGFA or VEGF) is a growth factor and signaling protein involved in the regulation of angiogenesis, vasculogenesis, and …
VWA5A
From NCBI Gene: Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021] From UniprotKB/SwissProt: May play a role in tumorigenesis as a …
WBP4
From NCBI Gene: This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with …
WIPI1
From NCBI Gene: This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They …
YWHAE
From NCBI Gene: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. …
ZNF117
From NCBI Gene: This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Readthrough transcription occurs between this gene and the …
ZNF219
From NCBI Gene: This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high …
ZNF263
From NCBI Gene: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. …
ZNF292
From NCBI Gene: This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring …

Projects

A Urine Exosome Gene Expression Panel Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy
To evaluate a Urine Exosome Gene Expression Panel that Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy, including African American …
Biomarkers for Early Detection of Clinically Relvant Prostate Cancer: A Multi-Institutional Validation Trial - Genomic Health, Inc.
Validate a panel of tissue-based biomarkers to determine the presence of or progression to clinically relevant prostate cancer at the time of diagnosis. …
Germline Genetic Variants and Faliure of Acitve Sureveillance
Study the impact of germline genetic variants on Active Surveillance (AS) failure. Information will help develop methods for identifying men with low-risk PC …
Glycoprotein Biomarkers for the Early Detection of Aggressive Prostate Cancer
This proposal is focused on a means to improve the selection of men with indolent CaP to undergo AS and identify those men who unexpectedly may have very …
High Promoter Methylation Levels of APC Predict Poor Prognosis in Sextant Biopsies from Prostate Cancer Patients
see publication … (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Improving Prostate Cancer Outcome Prediction Through Noninvasive exRNA Assessment
Our goal is to identify and validate across multiple clinical scenarios a novel circulating biomarker signature that can refine patient stratification, …
Mitochondrial genome deletion aids in the identification of false- and true-negative prostate needle core biopsy specimens
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies independent predictors of recurrence
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
MSA Bladder Reference Set Application: Charles Rosser-Hawaii (2014)
The goal of this proposal is straightforward. We wish to assay in a discovery set, reference set from EDRN, both PAI-1 and ANG promoters and genes for …
Optimal Use of a Panel of Methylation Markers with the GSTP1 Hypermethylation in the Diagnosis of Prostate Adenocarcinoma
see publication … (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Carroll Univ. of California SF (2012) PC101769 Predicting Prostate Cancer Progression at Time of Diagnosis
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Lin Univ. of Washington/OncoChip (2013)
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Lin Univ. of Washington/OPKO (2015)
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Nelson Fred Hutchinson Cancer Research Center (2013) Telomere Length in men with Prostate Cancer under Active Surveillance
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Ruth Etzioni-William Beaumont Hospital (2014)
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PCA-3 Reference Set Application: Zhang/Johns Hopkins: Glycoprotein Biomarkers for the Early Detection of Aggressive Prostate Cancer
This project aims to determine the performance of using urinary glycoproteins for the early detection of aggressive prostate cancer (PCa). Using …
PCA3 Reference Set Application: Samantha Maragh NIST
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PCA3 Reference Set Application: Arul Chinnaiyan (2020)
The MyProstateScore (MPS) test was validated for improved detection of clinically-significant (Grade Group [GG] ≥2) prostate cancer relative to PSA-based …
Plasma bile acid concentrations among men with prostate cancer on active surveillance
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Prostate Rapid Pre-Validation Set
Determine which markers move to validation using the prospectie prostate reference set samples. … Other, Specify … (Collaborative Groups: Prostate and Urologic …
Prostate Rapid Reference Set Application: Robert Getzenberg - John Hopkins (2006)
Analyze marker EPCA2 on 123 observations (60 prostate cancers and 63 non-prostate cancers) … (Collaborative Groups: Prostate and Urologic Cancers Research …
Prostate Rapid Reference Set Application: Daniel Chan/Patty Beckman- JHU/University of Minnesota (2007)
Evaluate performance of [-2]proPSA as an early detection marker for prostate cancer … Proteomics … (Collaborative Groups: Prostate and Urologic Cancers …
Prostate Upgrading Team Project
Aim 1: We will develop a risk assessment tool using commonly-collected clinical information from a series of contemporary radical prostatectomies to predict …
Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression
To develop a panel of protein biomarkers, detectable in radical prostatectomy samples from men with organ-confined PCa, to stratify patients for risk of …
Quantitative Methylation Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distringuish Prostate Cancer Patients From Control Subjects
see publication … (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Standard Specimen Reference Set: Prostate
To collect biologic samples on men prior to prostate biopsy, in association with clinical information and common data elements appropriate for evaluation of …
Upgrading Reference Set (URS) Application: Paul Boutros-UCLA (2020)
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)

Protocols

A Methylation Panel for Bladder Cancer
Participate in a prevalidation study for methylation based detection of bladder cancer. In addition, a panel of three markers identified will be evaluated for …
Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer - Supplemental Pre-Validation Protocol
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Biomarker Development Laboratory
… (Collaborative Groups: Breast and Gynecologic Cancers Research Group, Prostate and Urologic Cancers Research Group)
Biomarker Discovery for Renal Cell Carcinoma Through Serum, Urine and Tissue Protein Profiles
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Biomarkers for Early Detection of Aggressive Prostate Cancer
Although ~40% of screen-detected prostate cancers (PCa) are indolent, advanced-stage PCa is a lethal disease with 5-year survival rates around 29%. The …
Biomarkers for Prostate and Bladder Cancer
To identify potential cancer-specific protein biomarkers via genomic analysis of differential gene expression between cancer cells and their normal …
Body Fluids as a Source of Diagnostic Biomarkers: Prostate
Collection of bodu fluids for the purpose of early validation of the SELDI-TOF based assay for detection of PCa. The fluids were also utilized for determining …
Body Fluids as a Source of Diagnostic Biomarkers
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Characterization of SPINK1 in Prostate Cancer (A sub-study of a single biomarker)
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Chemokine Prostate Cancer Biomarkers
CXCL5 is a pro-angiogenic CXC-type chemokine that is robustly secreted by prostate cancer cells. Tissue microarray analyses have demonstrated that CXCL5 …
Clinical Utility of Urinary CD90 as a Biomarker for Prostate Cancer Detection
CD90/THY1 is overexpressed by tumor-associated stromal cells as scored by immunohistochemistry, RT-PCR analysis of laser-capture microdissected cells. CD90 …
Detection of Bladder CA by Microsatellite Analysis (MSA)
Goal 1: To determine sensitivity and specificity of microsatellite analysis (MSA) of urine sediment, using a panel of 15 microsatellite markers, in detecting …
Development and Clinical Validation of Biomarkers for Prostate Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Development and Evaluation of a Tumor Marker for Prostate Cancer
The primary objective is to work with the EDRN steering committee, the NCI administration, EDRN co-investigators, industrial partners and other biomarker …
Development and Validation of Tissue Microarray Technology to Evaluate Molecular Alterations in Cancer. IRBMED# 2000-0108
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Discovery of Novel Gene Elements Associated with Prostate Cancer Progression
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Discovery of novel genomic classifiers for improved management of active surveillance patients
. Primary Study Objective(s): Discover and validate a fit-for-purpose gene-expression based signature for the active surveillance population II. Secondary …
Early Detection of Cancer by Affinity Mass Spectrometry-Set Aside funds
A.   RATIONALE The recent introduction of multiple reaction monitoring capabilities offers unprecedented capability to the research arsenal available to …
Early Detection of Urinary Bladder Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Early Molecular Detection of Invasive Bladder Cancer by Urine Examination
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
EDRN Pre-Validation of Metabolic Biomarkers of Prostate Cancer: Follow up EDRN Challenge
The goal of this EDRN set-asides proposal is to carry out pre-validation studies on sarcosine as a metabolomic biomarker of prostate cancer in urine. Not only …
EDRN Pre-Validation of Multiplex Biomarker in Urine
The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in …
Establishment of a serum standard for use in high-throughput proteomic
… (Collaborative Groups: Breast and Gynecologic Cancers Research Group, Prostate and Urologic Cancers Research Group)
Evaluating SelectMDx for the prediction of high-grade prostate cancer in men with low-grade prostate cancer on active surveillance in the Canary Prostate Active Surveillance Study (PASS)
The need for repeated biopsy is a major downside of active surveillance, and can lead to patients opting for definitive treatment or, conversely, declining to …
Evaluation of emerging tissue-based biomarkers for aggressive prostate cancer in men on active surveillance
This work is being done as part of the funded NIH grant entitled Precision Medicine Approach to Prostate Cancer Active Surveillance (R01 CA184712; PD-PIs Mark …
Evaluation of tissue biomarker of Urologic cancer, including prostate, bladder and kidneys using surplus human tissues
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
GSTP1 Methylation
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Identification of protein and genetic biomarkers of prostate cancer and risk factors for progression of disease
To collect biological samples from subjects with prostate cancer to improve the accuracy of prostate screening, identify markers that will predict how …
Inflammation as a Potential Marker of Risk ad Progression for Prostate Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Integrated Development of Novel Molecular Markers
… (Collaborative Groups: Lung and Upper Aerodigestive Cancers Research Group, Prostate and Urologic Cancers Research Group)
Investigating Circulating Metabolism-Related Biomarkers and Diet in an Active Surveillance Population
Develop non-invasive, biomarker-driven interventions that can limit or slow disease progression in men on active surveillance. … Proteomics … (Collaborative …
Methylation & Proteomics-Based Detection of Bladder Cancer
To determine sensitivity and specificity of quantitative real-time methylation specific PCR (qMSP) of urine sediment DNA, using a panel of several methylated …
Molecular Genetics of Urinary Bladder Carcinoma
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Molecular Profiling of Cancer: Identification and Characterization of Candidate Biomarkers and Regulatory Genes. IRBMED # 2001-0155
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Molecular Progression of Methylation in Bladder Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Ornithine decarboxylase (ODC) Polymorphism and Breast and Prostate Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Thompson UT Health Science Center San Antonio (2014) SNPs for PCa Outcome
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS
Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive …
PCA3 Reference Set Application: T2-Erg-Martin Sanda-Emory (2014)
We hypothesize that combining T2:erg (T2:erg) fusion and PCA3 detection in urine collected after digital rectal exam can improve the specificity of identifying …
PCA3 Reference Set Application: Aim 5 of P-MRI Study-John Wei (2020)
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
PCA3 Validation Study and Urinary Reference Set
Independent of serum PSA level, PCA3 score will refine the risk of having cancer detected on an extended template prostate biopsy. … Proteomics … …
Pre-Validation of Metabolomic Biomarkers of Prostate Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Pre-validation of TMPRSS2:ERG+PCA3 risk models for men on active surveillance
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Prediction Rules Combining PHI with Urinary RNA Testing for Aggressive Prostate Cancer Detection
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Prediction rules for aggressive prostate cancer in AS population
We plan develop and validate prediction rules, based on PCA3 and phi along with clinical variables, for aggressive prostate cancer, i.e., Gleason score >= …
Prostate Active Surveillance Study
Primary Objective: To discover and confirm biomarkers that predict aggressive disease as defined by pre-specified histological, PSA, clinical criteria, or …
Prostate Biopsy Clinical Database/Tissue Bank IRBMED# 2004-0442
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Prostate Rapid Reference Set Application: Brian Haab - Van Andel (2006)
To evaluate TSP-1 as a marker to specifically detect prostate cancer … Proteomics … (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)
A blinded study coordinated by the EDRN GU Collaborative Group found the biomarker is not associated with prostate cancer risk … (Collaborative Groups: …
Prostate Reference Set Application: William Isaacs-John Hopkins (2010)
Can SNP genotyping assist in the prediction of biopsy results for prostate cancer. … Genomics … (Collaborative Groups: Prostate and Urologic Cancers Research …
Prostate Reference Set Application: proPSA-Dan Chan-JHU (2008)
Primary Objective – To validate the serum %[-2]proPSA marker for the improvement of diagnosis and risk assessment of prostate cancer and reducing unnecessary …
Prostate-MRI
•The primary aim of this study is to see if the addition of prostate MRI to a panel including PSA, PCA3, TMPRSS2:ERG will significantly improve …
Prostate-Specific Glycoproteins for Early Detection of Prostate Cancer
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Release of Set Aside Funds - microRNA Biomarkers for Renal Cell Carcinoma
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
San Antonio Center of Biomarkers of Risk for Prostate Cancer (SABOR)
To determine if there are ways to predict which men will get prostate cancer, if there are ways to predict how a prostate cancer will develop (for example, …
SELDI Phase I: Assay Validation-Prostate
It is then the goal of this collaborative project – EDRN-Prostate-SELDI Investigational Collaboration (EPSIC) - to use state-of-the-art protein profiling …
SELDI Profiling of serum and urine from patients with urologic disease in support of bladder cancer studies
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
SELDI Validation Study Phase II
This project –A Comprehensive Program for the Validation of Prostate Cancer Early Detection with Novel Protein Identification Techniques -- is divided into …
The Early Detection Research Network: Biomarker Reference Laboratories
… (Collaborative Groups: Breast and Gynecologic Cancers Research Group, Lung and Upper Aerodigestive Cancers Research Group, Prostate and Urologic Cancers …
The Prostate Tumor Microenvironment Exhibits differentially expressed Genes Useful for Diagnosis
This protocol for the use of human subjects in a prospective observational clinical trial of a new diagnostic test for prostate cancer that is based …
Tumor Profiling through High-throughput Sequencing
… (Collaborative Groups: Prostate and Urologic Cancers Research Group)
Upgrading Reference Set
We are proposing a multi-institutional study to identify molecular biomarkers and clinical measures that will predict presence of Gleason 7 or higher cancer …
Using MALDI-IMS and MRM to stablish a pipeline for discovery and validation of tumor neovasculature biomarker candidates.
In an effort to circumvent the limitations associated with biomarker discovery workflows involving cell lines and cell cultures, histology-directed MALDI …

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Past Events

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Title Type
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