Sidransky, David

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
A Methylation Panel for Bladder Cancer Involved 0 0
GSTP1 Methylation Leading 0 1
Indeterminate pulmonary nodule biomarker clinical utility trial Involved 0 0
Integrated Development of Novel Molecular Markers Coordinating 0 0
Molecular Progression of Methylation in Bladder Cancer Coordinating 0 0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) Involved 15 1

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer Involved 8 0
High Promoter Methylation Levels of APC Predict Poor Prognosis in Sextant Biopsies from Prostate Cancer Patients Coordinating 0 0
Identification of biomarkers for lung cancer in never smokers Involved 4 1
Methylation & Proteomics-Based Detection of Bladder Cancer Involved 0 0
Optimal Use of a Panel of Methylation Markers with the GSTP1 Hypermethylation in the Diagnosis of Prostate Adenocarcinoma Coordinating 0 0
Proteomic Approach for Diagnostic Applications in Head and Neck Cancer Involved 0 0
Protocol for Comparing Promoter Hypermethylation Methods in NSCLC Involved 0 0
Quantitative Methylation Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distringuish Prostate Cancer Patients From Control Subjects Coordinating 0 0


Publication NamePubMed IDJournal
A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma. 18006766 Clin Cancer Res
Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. 11429699 Oncogene
An oligonucleotide microarray for high-throughput sequencing of the mitochondrial genome. 16931588 J Mol Diagn
Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. 16565507 Am J Pathol
Assessment of gene promoter hypermethylation for detection of cervical neoplasia. 16736496 Int J Cancer
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. 11745231 Cancer
DCC promoter hypermethylation in esophageal squamous cell carcinoma. 18302152 Int J Cancer
Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. 14633692 Cancer Res
Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. 16533782 Clin Cancer Res
Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. 17018594 Cancer Res
Detecting cervical cancer by quantitative promoter hypermethylation assay on cervical scrapings: a feasibility study. 15192122 Mol Cancer Res
Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. 16908936 J Clin Oncol
Detection of LOH and mitochondrial DNA alterations in ductal lavage and nipple aspirate fluids from hngh-risk patients. 14999140 Breast Cancer Res Treat
Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. 11606403 Cancer Res
Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. 15073103 Clin Cancer Res
Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer. 16263813 J Clin Endocrinol Metab
Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. 15814621 Clin Cancer Res
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. 17020408 PLoS Med
Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. 12578990 Proc Natl Acad Sci U S A
Endothelin B receptor gene hypermethylation in prostate adenocarcinoma. 12499435 J Clin Pathol
Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. 17534889 Int J Cancer
Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. 17980147 Biochem Biophys Res Commun
Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. 18172258 Clin Cancer Res
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. 17456604 Proc Natl Acad Sci U S A
Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. 15812243 DNA Cell Biol
Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients. 12684406 Clin Cancer Res
Genome-wide promoter analysis uncovers portions of the cancer methylome. 18413733 Cancer Res
High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients. 17947477 Clin Cancer Res
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. 18234960 Mol Cancer Res
Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer. 17016690 J Mol Med (Berl)
Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis. 12727855 Cancer Res
I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. 12010858 Cancer Epidemiol Biomarkers Prev
Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. 11585726 Cancer Res
Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. 17118488 Lung Cancer
Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. 11280771 Cancer Res
Increased mitochondrial DNA content in saliva associated with head and neck cancer. 15814624 Clin Cancer Res
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. 15342377 Cancer Res
Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma. 17360030 Gynecol Oncol
LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. 16912160 Cancer Res
Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer. 11550279 Genes Chromosomes Cancer
Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. 15753360 Cancer Res
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. 17456585 Cancer Res
Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. 12727856 Cancer Res
Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues. 11448537 Cancer Lett
Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. 12114429 Clin Cancer Res
Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. 18245469 Cancer Res
Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma. 11839667 Clin Cancer Res
Mitochondrial DNA alterations in thyroid cancer. 12619060 J Surg Oncol
Mitochondrial DNA as a cancer biomarker. 15858150 J Mol Diagn
Mitochondrial DNA content increase in response to cigarette smoking. 16434581 Cancer Epidemiol Biomarkers Prev
Mitochondrial DNA mutations in human cancer. 16892080 Oncogene
Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer. 17166268 Mol Cancer
Mitochondrial mutations in early stage prostate cancer and bodily fluids. 11526508 Oncogene
Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer. 18094415 Clin Cancer Res
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study. 11882817 J Thorac Cardiovasc Surg
Molecular characteristics of non-small cell lung cancer. 11752463 Proc Natl Acad Sci U S A
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. 11555585 Clin Cancer Res
Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer. 15515012 Int J Cancer
MT1G hypermethylation is associated with higher tumor stage in prostate cancer. 15894685 Cancer Epidemiol Biomarkers Prev
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer. 11410508 Clin Cancer Res
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer. 11719438 Cancer Res
Optimal use of a panel of methylation markers with GSTP1 hypermethylation in the diagnosis of prostate adenocarcinoma. 15328191 Clin Cancer Res
Oxidized guanine lesions and hOgg1 activity in lung cancer. 15856018 Oncogene
p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study. 12837832 J Natl Cancer Inst
PGP9.5 methylation in diffuse-type gastric cancer. 16585221 Cancer Res
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. 15930319 Cancer Res
Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. 17592394 Laryngoscope
Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. 16322291 Clin Cancer Res
Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. 11448914 Clin Cancer Res
Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. 11221887 Cancer Res
Proteomic analysis of cancer-cell mitochondria. 14570046 Nat Rev Cancer
Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma. 11717336 J Natl Cancer Inst
Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. 16849682 J Natl Cancer Inst
Quantitation of serum prostate-specific membrane antigen by a novel protein biochip immunoassay discriminates benign from malignant prostate disease. 11507047 Cancer Res
Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. 11809682 Cancer Res
Quantitative assessment of promoter methylation profiles in thyroid neoplasms. 15840741 J Clin Endocrinol Metab
Quantitative detection of promoter hypermethylation as a biomarker of acute kidney injury during transplantation. 17175292 Transplant Proc
Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. 15289362 Cancer Res
Quantitative GSTP1 hypermethylation in bodily fluids of patients with prostate cancer. 12475696 Urology
Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies. 14600096 J Natl Cancer Inst
Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma. 12576869 J Urol
Quantitative GSTP1 methylation levels correlate with Gleason grade and tumor volume in prostate needle biopsies. 15126784 J Urol
Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. 17549626 Breast Cancer Res Treat
Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. 16170165 J Clin Oncol
Quantitative RARbeta2 hypermethylation: a promising prostate cancer marker. 15217932 Clin Cancer Res
RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma. 16619251 Int J Cancer
Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations. 12917199 Cancer Epidemiol Biomarkers Prev
Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. 17405999 J Natl Cancer Inst
Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. 18246124 Oncogene
Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. 17018150 BMC Cancer
The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. 15123581 Genome Res
The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. 16862168 Oncogene
Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. 18082200 J Urol


Identifying mitochondrial alterations (mutations) in human cancers and developing assays for their detection in clinical samples

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Sidransky, David
Johns Hopkins University
(410) 614-1411
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EDRN Title
EDRN Principal Investigator
To update contact information, please visit the Data Management and Coordinating Center .