Block, Timothy

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Detection of cancer DNA markers in urine Leading 0 0
Early detection of liver cancer and hepatitis Coordinating 3 0
SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas Involved 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Liver Full Reference Set Application :Timothy Block - Drexel Univ (2010) Leading 4 0
Liver Rapid Reference Set Application: Timothy Block - Drexel Univ (2008) Leading 4 0


Publication NamePubMed IDJournal
A phage with high affinity for hepatitis B surface antigen for the detection of HBsAg. 15109821 J Virol Methods
A proteomic approach for the discovery of early detection markers of hepatocellular carcinoma. 11790885 Dis Markers
A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma. 12748940 Proteomics
Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. 14997503 Proteomics
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. 17237271 Mol Cancer Ther
Detection of a K-ras mutation in urine of patients with colorectal cancer. 17192038 Cancer Biomark
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. 18837947 Ann N Y Acad Sci
Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity? 16569195 DNA Cell Biol
Efficient and specific removal of albumin from human serum samples. 12754305 Mol Cell Proteomics
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma. 16137783 J Hepatol
Hepatitis B and hepatitis C virus replication upregulates serine protease inhibitor Kazal, resulting in cellular resistance to serine protease-dependent apoptosis. 19864383 J Virol
Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays. 16780964 Antiviral Res
Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells. 12692252 J Virol
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer. 15096565 J Mol Diagn
Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma. 19099421 J Proteome Res
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis. 18045939 J Virol
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. 19091367 Virology
Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. 16760258 Mol Cell Proteomics
Molecular viral oncology of hepatocellular carcinoma. 12910247 Oncogene
Molecular virology of hepatitis B virus for clinicians. 17981225 Clin Liver Dis
N-linked glycosylation of the liver cancer biomarker GP73. 18004786 J Cell Biochem
Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma. 19454616 Cancer Epidemiol Biomarkers Prev
Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA. 14709652 Clin Chem
Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma. 16457596 J Proteome Res
Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes. 19187787 J Virol Methods
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine. 18837929 Ann N Y Acad Sci
SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma. 15726646 Hepatology
Symptomatology and health attitudes of chronic hepatitis B patients in the USA. 18088244 J Viral Hepat
Transrenal DNA as a diagnostic tool: important technical notes. 15251944 Ann N Y Acad Sci
Underestimation of chronic hepatitis B virus infection in the United States of America. 18088239 J Viral Hepat
Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. 15642945 Proc Natl Acad Sci U S A


No interests found at the present moment.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Block, Timothy
Drexel University College of Medicine
(215) 489-4920
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EDRN Title
EDRN Associate Member
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