Batra, Surinder

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
A Biomarker Bakeoff in Early Stage Pancreatic Cancer Involved 11 0
Pancreatic Cancer Bake Off 2 Involved 4 0
Pre-diagnostic Pancreatic Cancer Set Aside Project Involved 25 0
Validation of plasma biomarker panels for the early detection of pancreatic cancer Involved 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Pancreatic Reference Set Application: Surinder Batra- University of Nebraska (2014) Leading 2 0


Publication NamePubMed IDJournal
Aberrant upregulation of MUC4 mucin expression in cutaneous condyloma acuminatum and squamous cell carcinoma suggests a potential role in the diagnosis and therapy of skin diseases. 20591909 J Clin Pathol
Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. 21364589 Br J Cancer
Aging of tissue-resident adult stem/progenitor cells and their pathological consequences. 19776709 Panminerva Med
Analysis of tumor-associated mucin glycotopes by Western transfer methods. 23359164 Methods Mol Biol
Antibody labeling with radioiodine and radiometals. 24567137 Methods Mol Biol
Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies. 21615592 Brain Pathol
Current status of molecular markers for early detection of sporadic pancreatic cancer. 20888394 Biochim Biophys Acta
Current status of mucins in the diagnosis and therapy of cancer. 19904814 Biofactors
Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. 21391573 Anal Chem
Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer. 22820136 Cancer Biomark
Discovering the route from inflammation to pancreatic cancer. 23207606 Minerva Gastroenterol Dietol
Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer. 20578239 J Cell Physiol
DNA methylation and histone H3-K9 modifications contribute to MUC17 expression. 20926598 Glycobiology
Early diagnosis of pancreatic cancer: challenges and new developments. 23075238 Biomark Med
Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. 20423995 Mol Cancer Ther
Elevated serum neutrophil gelatinase-associated lipocalin is an early predictor of severity and outcome in acute pancreatitis. 20179686 Am J Gastroenterol
Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials. 22903142 Drug Discov Today
Emerging role of mucins in epithelial to mesenchymal transition. 24168188 Curr Cancer Drug Targets
Emerging trends for radioimmunotherapy in solid tumors. 23844555 Cancer Biother Radiopharm
Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon. 20702471 J Clin Pathol
Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. 22970168 PLoS One
Expression of MUC4 mucin is observed mainly in the intestinal type of intraductal papillary mucinous neoplasm of the pancreas. 23921963 Pancreas
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. 20716670 Pharmacol Rev
Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. 22475682 Cancer Lett
Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. 22457110 Adv Exp Med Biol
Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. 23920124 Cancer Lett
Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: potential role in therapy. 23523869 Cancer Lett
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. 22046413 PLoS One
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells. 23301832 J Cell Mol Med
Immunohistochemistry of pancreatic neoplasia. 23359148 Methods Mol Biol
Incidence and prognostic significance of second primary cancers in renal cell carcinoma. 22441339 Am J Clin Oncol
Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis. 22623649 Carcinogenesis
Lung cancer in women: role of estrogens. 20658912 Expert Rev Respir Med
Marital status and survival in pancreatic cancer patients: a SEER based analysis. 21698253 PLoS One
Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. 20348949 Oncogene
MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications. 20004512 Cancer Lett
Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers. 24273063 Cancer Epidemiol Biomarkers Prev
Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer. 21886786 PLoS One
MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells. 21785467 Oncogene
Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity. 21393431 Am J Physiol Gastrointest Liver Physiol
MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancer. 23152882 PLoS One
MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. 20303649 Cancer Lett
MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. 20697346 Oncogene
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. 23102107 J Hematol Oncol
Mucin-based targeted pancreatic cancer therapy. 22372499 Curr Pharm Des
Mucin-interacting proteins: from function to therapeutics. 19913432 Trends Biochem Sci
Mucins and toll-like receptors: kith and kin in infection and cancer. 22306702 Cancer Lett
Mucins in pancreatic cancer and its microenvironment. 23856888 Nat Rev Gastroenterol Hepatol
Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy. 21277939 Biochim Biophys Acta
Nano-immunoassay with improved performance for detection of cancer biomarkers. 25200613 Nanomedicine
Neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1, and carbohydrate antigen 19-9 in pancreatic juice: pathobiologic implications in diagnosing benign and malignant disease of the pancreas. 23146921 Pancreas
New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence. 20552555 Histol Histopathol
New promising drug targets in cancer- and metastasis-initiating cells. 20338259 Drug Discov Today
Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation. 22614008 Oncogene
Novel biomarkers and therapeutic targets for optimizing the therapeutic management of melanomas. 22442756 World J Clin Oncol
Novel INTeraction of MUC4 and galectin: potential pathobiological implications for metastasis in lethal pancreatic cancer. 21059814 Clin Cancer Res
Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: applications in diagnosis and therapy. 24278292 PLoS One
Novel therapies against aggressive and recurrent epithelial cancers by molecular targeting tumor- and metastasis-initiating cells and their progenies. 20184544 Anticancer Agents Med Chem
Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis. 22977192 Clin Cancer Res
Pathobiological implications of MUC16 expression in pancreatic cancer. 22066010 PLoS One
Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. 21859497 Chin Med
Potentials of plasma NGAL and MIC-1 as biomarker(s) in the diagnosis of lethal pancreatic cancer. 23383312 PLoS One
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab. 21691572 Case Rep Oncol
Prospects of miRNA-based therapy for pancreatic cancer. 23834151 Curr Drug Targets
Quantitative real-time PCR expression analysis of peripheral blood mononuclear cells in pancreatic cancer patients. 23359153 Methods Mol Biol
Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. 19725922 J Cell Mol Med
Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications. 19114129 Ageing Res Rev
Recent trends in antibody-based oncologic imaging. 22104729 Cancer Lett
Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells. 22105367 Oncogene
Role of mucins in the skin during benign and malignant conditions. 21146919 Cancer Lett
Smoking and microRNA dysregulation: a cancerous combination. 24238736 Trends Mol Med
Targeting the EGFR signaling pathway in cancer therapy. 22239438 Expert Opin Ther Targets
The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. 22513004 Biochim Biophys Acta
Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility. 21347333 PLoS One


Pancreatic cancer; Tumor-associated genes; cancer diagnostics
Early detection of pancreatic cancer

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Photograph of Batra, Surinder
University of Nebraska Medical Center
Person ID
EDRN Title
EDRN Principal Investigator
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