Lokshin, Anna

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
A Biomarker Bakeoff in Early Stage Pancreatic Cancer Involved 11 0
Biomarkers for early detection of pancreatic cancer Coordinating 0 1
Pancreatic Cancer Bake Off 2 Involved 4 0
Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside) Coordinating 0 1
Pre-diagnostic Pancreatic Cancer Set Aside Project Involved 25 0
Standard Specimen Reference Set: Breast Cancer and Imaging Involved 0 3
Validation of plasma biomarker panels for the early detection of pancreatic cancer Involved 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
BRSCW Reference Set Application: Anna Lokshin - Univ of Pitts (2008) Leading 24 0
Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer Involved 7 0
PLCO Ovarian Phase III Validation Study Involved 50 1
Prostate Rapid Pre-Validation Set Involved 6 0
SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study Involved 55 2


Publication NamePubMed IDJournal
Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). 17337770 Immunol Res
Adenosine-mediated inhibition of the cytotoxic activity and cytokine production by activated natural killer cells. 16885379 Cancer Res
Assessment of 54 biomarkers for biopsy-detectable prostate cancer. 17932343 Cancer Epidemiol Biomarkers Prev
Biomarker approaches to the development of cancer screening tests: can cancer blood tests become a routine health check-up? 17547524 Future Oncol
Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer. 16434085 Gynecol Oncol
Combined antiangiogenic and immune therapy of prostate cancer. 16132614 Angiogenesis
Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. 18327580 Cancer Immunol Immunother
Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin. 17659325 Gynecol Oncol
Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. 12202400 Int Immunol
Dynamic alteration of soluble serum biomarkers in healthy aging. 17689975 Cytokine
Early detection and staging of adenocarcinoma of the pancreas. 17533087 Gastroenterol Clin North Am
Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling. 17220337 Cancer Epidemiol Biomarkers Prev
Early effects of retinoic acid on proliferation, differentiation and apoptosis in non-small cell lung cancer cell lines. 10697544 Anticancer Res
Effect of suramin on squamous differentiation and apoptosis in three human non-small-cell lung cancer cell lines. 8806101 J Cell Biochem Suppl
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. 16737935 Biol Blood Marrow Transplant
High-sensitivity blood-based detection of breast cancer by multi photon detection diagnostic proteomics. 16889412 J Proteome Res
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth. 14695193 Cancer Res
IL-12 receptor-mediated upregulation of FasL in human ovarian carcinoma cells. 15382042 Int J Cancer
Induction of squamous differentiation by interferon beta in a human non-small-cell lung cancer cell line. 7905929 J Natl Cancer Inst
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling. 17575165 Cancer Res
Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3. 10100610 FEBS Lett
Interleukin-2-induces development of denditric cells from cord blood CD34+ cells. 9581807 J Leukoc Biol
Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies? 17029028 Cancer Metastasis Rev
Intravenous and isolated limb perfusion delivery of wild type and a tumor-selective replicating mutant vaccinia virus in nonhuman primates. 16409123 Hum Gene Ther
Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis? 15880317 Clin Gastroenterol Hepatol
Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo. 15843547 J Immunol
Low-dose paclitaxel prior to intratumoral dendritic cell vaccine modulates intratumoral cytokine network and lung cancer growth. 17875775 Clin Cancer Res
Mechanism of interferon beta-induced squamous differentiation and programmed cell death in human non-small-cell lung cancer cell lines. 7707408 J Natl Cancer Inst
Mechanisms of growth stimulation by suramin in non-small-cell lung cancer cell lines. 10071987 Cancer Chemother Pharmacol
Multianalyte profiling of serum cytokines for detection of pancreatic cancer. 17192050 Cancer Biomark
Multiple biomarker panels for early detection of ovarian cancer. 17155900 Future Oncol
Multiple effects of TRAIL in human carcinoma cells: induction of apoptosis, senescence, proliferation, and cytokine production. 18313665 Exp Cell Res
Multiplex analysis of serum cytokines in melanoma patients treated with interferon-alpha2b. 17438101 Clin Cancer Res
Multiplexed immunobead-based cytokine profiling for early detection of ovarian cancer. 15824174 Cancer Epidemiol Biomarkers Prev
New tumor markers: CA125 and beyond. 16343244 Int J Gynecol Cancer
Obesity, adipokines, and prostate cancer in a prospective population-based study. 16835332 Cancer Epidemiol Biomarkers Prev
Physiological and molecular effects of Apo2L/TRAIL and cisplatin in ovarian carcinoma cell lines. 12536078 Cancer Lett
Prevention and early detection of ovarian cancer: mission impossible? 17302189 Recent Results Cancer Res
Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt. 12878156 Exp Cell Res
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1. 16728283 Exp Hematol
Role of antiapoptotic proteins in tumor necrosis factor-related apoptosis-inducing ligand and cisplatin-augmented apoptosis. 12912965 Clin Cancer Res
Tumor's other immune targets: dendritic cells. 10449178 J Leukoc Biol


Biomarkers for early cancer detection
My interests focus on the discovery of multibiomarker profiles that allow for early detection of cancer. To-date,we have identified biomarker panels with strong diagnostic power for ovarian, pancreatic, and endometrial cancers.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Lokshin, Anna
University of Pittsburgh Cancer Institute
Person ID
EDRN Title
EDRN Associate Member
To update contact information, please visit the Data Management and Coordinating Center .