Final Agenda

Tuesday, June 30, 2020
11:00 a.m. – 6:00 p.m. EDT

Chair:

Steven Skates, Ph.D., Massachusetts General Hospital

Co-Chair:

Christopher Li, M.D., Ph.D., Fred Hutchinson Cancer Research Center

NCI Program Directors:

Christos Patriotis, Ph.D., and Sharmistha Ghosh-Janjigian, Ph.D., National Cancer Institute

11:00 a.m. – 11:05 a.m. EDT	Welcome and Introductions Steven Skates, Ph.D., Massachusetts General Hospital Christos Patriotis, Ph.D., National Cancer Institute
11:05 a.m. – 11:45 a.m. EDT	BGYN01: Objective, Charge and Progress of Collaborative Group Steven Skates, Ph.D., Massachusetts General Hospital Christopher Li, M.D., Ph.D., Fred Hutchinson Cancer Research Center
11:45 a.m. – 12:25 p.m. EDT	Pros and Cons of Pan-Cancer Detection Approach: Should EDRN Increase Focus on Such an Approach? (10+10 min talk, 20 min discussion) Moderator:Christopher Li, M.D., Ph.D., Fred Hutchinson Cancer Research Center
11:45 a.m. – 11:55 a.m. EDT	BGYN02: Noninvasive Multi-Cancer Screening Using Liquid Biopsy Nicholas Papadopoulos, Ph.D., Johns Hopkins University School of Medicine
11:55 a.m. – 12:05 p.m. EDT	BGYN03: Simultaneous Multi-Cancer Detection using a Cell-free Nucleic Acid Assay Brian Allen, M.S., GRAIL
12:05 p.m. – 12:25 p.m. EDT	Discussants: Steven Skates, Ph.D., Massachusetts General Hospital Karen Anderson, M.D., Ph.D., Arizona State University/The Biodesign Institute Zhen Zhang, Ph.D., Johns Hopkins University School of Medicine
12:25 p.m. – 1:05 p.m. EDT	Integration of Germline Genomics and Circulating Biomarkers for Early Cancer Detection (20 min talk, 20 min discussion) Moderator:Christos Patriotis, Ph.D., National Cancer Institute
12:25 p.m. – 12:45 p.m. EDT	BGYN04: Tailoring Early Detection Strategies for Breast and Ovarian Cancer to Genomic Risk Mary Daly, M.D., Fox Chase Cancer Center
12:45 p.m. – 1:05 p.m. EDT	Discussants: Christopher Li, M.D., Ph.D., Fred Hutchinson Cancer Research Center Robert Bast, M.D., The University of Texas MD Anderson Cancer Center Yiwey Shieh, M.D., University of California San Francisco
1:05 p.m. – 1:30 p.m. EDT	Break
1:30 p.m. – 2:10 p.m. EDT	ctDNA for Early Cancer Detection Biomarker Development (10+10 min talk, 20 min discussion) Moderator:Sharmistha Ghosh-Janjigian, Ph.D., National Cancer Institute
1:30 p.m. – 1:40 p.m. EDT	BGYN05: ctDNA for Early Cancer Detection: Promise, Challenges, and Emerging Solutions Abhijit Patel, M.D., Ph.D., Yale School of Medicine
1:40 p.m. – 1:50 p.m. EDT	BGYN06: Cell-free DNA for Early Cancer Detection Xianghong Jasmine Zhou, Ph.D., University of California Los Angeles
1:50 p.m. – 2:10 p.m. EDT	Discussants: Nicholas Papadopoulos, Ph.D., Johns Hopkins University School of Medicine Steven Skates, Ph.D., Massachusetts General Hospital
2:10 p.m. – 2:50 p.m. EDT	Exosomes and Early Cancer Detection Biomarker Development (10+10 min talk, 20 min discussion) Moderator:Steven Skates, Ph.D., Massachusetts General Hospital
2:10 p.m. – 2:20 p.m. EDT	BGYN07: Microfluidics for the Isolation and Tracking of Tumor Extracellular Vesicles Shannon Stott, Ph.D., Massachusetts General Hospital
2:20 p.m. – 2:30 p.m. EDT	BGYN08: Exosome Proteomics For Early Cancer Detection David Lyden, M.D., Ph.D., Weill Cornell Medicine, Drukier Institute for Children's Health
2:30 p.m. – 2:50 p.m. EDT	Discussants: Johan Skog, Ph.D., Exosome Diagnostics Andrew Godwin, Ph.D., Kansas University Medical Center
2:50 p.m. – 3:15 p.m. EDT	Break
3:15 p.m. – 3:55 p.m. EDT	Exploring the Tumor-Associated Lymphoid Cell Compartment for Advancing the Early Cancer Detection Research Space (10+10 min talk, 20 min discussion) Moderator:Steven Skates, Ph.D., Massachusetts General Hospital
3:15 p.m. – 3:25 p.m. EDT	BGYN09: Detect Early-Stage Cancers From the Blood T cell Repertoire Bo Li, Ph.D., University of Texas Southwestern
3:25 p.m. – 3:35p.m. EDT	BGYN10: Probing the micro-environment of Breast Pre-cancerous lesions Olivier Harismendy, Ph.D., University of California San Diego
3:35 p.m. – 3:55 p.m. EDT	Discussants: Charles Drescher, M.D., Fred Hutchinson Cancer Research Center Jeffrey Marks, Ph.D., Duke University Medical Center
3:55 p.m. – 4:35 p.m. EDT	Imaging and Artificial Intelligence in Early Cancer Detection (10+10 min talk, 20 min discussion) Moderator:Christos Patriotis, Ph.D., National Cancer Institute
3:55 p.m. – 4:05p.m. EDT	BGYN11: Mammography AI in EDRN Imaging Joseph Lo, Ph.D., Duke University
4:05 p.m. – 4:15 p.m. EDT	BGYN12: Implementing AI in early cancer detection Ashish Mahabal, Ph.D., California Institute of Technology/Jet Propulsion Laboratory
4:15 p.m. – 4:35 p.m. EDT	Discussants: Victoria Seewaldt, M.D., City of Hope Comprehensive Cancer Center Jennifer Barton, Ph.D., University of Arizona John Heine, Ph.D., H. Lee Moffitt Cancer Center and Research Institute, Inc.
4:35 p.m. – 4:45 p.m. EDT	Break
4:45 p.m. – 6:00 p.m. EDT	SWOT (Strengths, Weaknesses, Opportunities, and Threats) Analysis Moderator: Joshua LaBaer, M.D., Ph.D., Arizona State University/The Biodesign Institute Discussants: Karen Anderson, M.D., Ph.D., Arizona State University/The Biodesign Institute Charles Drescher, M.D., Fred Hutchinson Cancer Research Center Jeffrey Marks, Ph.D., Duke University Medical Center Discuss the strengths of EDRN and suggestions to further strengthen the Network Identify weaknesses and discuss the solutions (Mitigation) Discuss opportunities and highlight prioritized opportunities Discuss threats (competing interests/research) and mitigations
6:00 p.m. EDT	Adjourn