PSA
- Aliases
-
- APS
- EC 3.4.21.77
- Gamma-seminoprotein
- KLK2A1
- KLK3
- KLK3 (PSA)
- Kallikrein-3
- P-30 antigen
- PSA
- Semenogelase
- Seminin
- gamma-seminoprotein
- hK3
- kallikrein 3, (prostate specific antigen)
- kallikrein-3
- kallikrein-related peptidase 3
- prostate specific antigen
- prostate-specific antigen
- semenogelase
- seminin
- Description
- KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are increasingly thought to be involved in carcinogenesis, and many act as cancer biomarkers. The product of the KLK3 gene is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum. KLK3, or PSA, is well known for its role in diagnosing and monitoring prostate cancer. There are several isoforms of KLK3, generated by alternate splicing and transcript variants.
Attributes
- QA State
- Curated
- Type
- Proteomic
- HGNC Name
- KLK3
- Certifications
-
- None
- QA State for Breast
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray.
- A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness.
- Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease.
- From prostate-specific antigen (PSA) to precursor PSA (proPSA) isoforms: a review of the emerging role of proPSAs in the detection and management of early prostate cancer.
- [-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.