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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
Detection of Serum Markers of Breast Cancer by SELDI Marks, Jeffrey
Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study Esserman, Laura J.
Detection of cancer DNA markers in urine Block, Timothy
Development and Clinical Validation of Biomarkers for Prostate Cancer Partin, Alan W
Development and Evaluation of a Tumor Marker for Prostate Cancer Major strides in the early detection, staging, monitoring, and risk stratification of men with prostate cancer have been realized over the last few decades. ... Partin, Alan W
Development of FISH-based assay for early detection of high grade cervical dysplasia Unger, Elizabeth R.
Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer Gambhir, Sanjiv
Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets Esserman, Laura J.
Dubinett - Targeted Sequencing 2012 we propose to use targeted massively parallel DNA sequencing to identify somatic alterations within mutational hotspots in matched sets of primary lung tumors, ... Dubinett, Steve
EDRN Biomarker Reference Lab: Pacific Northwest National Laboratory The purpose of this project is to develop antibody microarrays incorporating three major improvements compared to previous antibody microarray platforms, and ... Rodland, Karin
EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project To identify promising candidate plasma early detection biomarkers specific to different molecular subtypes of breast cancer using preclinical specimens from ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ... Li, Christopher
EDRN Informatics Pilot Project Bigbee, William L.
EDRN Longitudinal Serum Biorepository Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ... Lynch, Henry
EDRN Pre-Validation of Metabolic Biomarkers of Prostate Cancer: Follow up EDRN Challenge The goal of this EDRN set-asides proposal is to carry out pre-validation studies on sarcosine as a metabolomic biomarker of prostate cancer in urine. Not only ... Chinnaiyan, Arul M.
EDRN Pre-Validation of Multiplex Biomarker in Urine The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in ... Chinnaiyan, Arul M.
EDRN Resource Network Exchange Create a distributed on-line virtual specimen repository. Srivastava, Sudhir
EDRN-WHI Pre-Clinical Colon Ca Specimens Specifically, it is proposed to assess plasma proteins from postmenopausal women diagnosed with colon cancer within a span of 18 months after year-3 OS blood ... Hanash, Samir
Early Detection Research Network Registry for Hereditary Cancer The EDRN High Risk Registry (HRR)recruits individuals that carry germline mutations for hereditary cancer syndromes, who are willing to participate in ... Lynch, Henry
Early Detection of Breast Cancer Using Autoantibody Markers To identify large numbers of antigens that can be used to recognize the presence of cancer by detecting antibodies to tumor proteins in the serum of the test ... Tainsky, Michael A.
Early Detection of Cancer by Affinity Mass Spectrometry-Set Aside funds A.   RATIONALE The recent introduction of multiple reaction monitoring capabilities offers unprecedented capability to the research arsenal available to ... Semmes, John
Early Detection of Urinary Bladder Cancer Czerniak, Bogdan
Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies Determining and quantifying the types of mucin core proteins to which CA19-9 is attached will result in assays with improved performance characteristics ... Hollingsworth, Michael
Early Molecular Detection of Invasive Bladder Cancer by Urine Examination Czerniak, Bogdan
Early detection of liver cancer and hepatitis Block, Timothy
Ecogenetic Study of Lung Cancer Spitz, Margaret R.
Establishment of a serum standard for use in high-throughput proteomic Semmes, John
Expression based markers for breast cancer detection Marks, Jeffrey
2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to http://grants.nih.gov /grants/guide/ pa-files/ PAR-15-289.html.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.