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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
Spectral Markers for Early Detection of Colon Neoplasia Not listed
Standard Specimen Reference Set: Breast The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ... Marks, Jeffrey
Standard Specimen Reference Set: Liver Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC Volk, Michael L.
Standard Specimen Reference Set: Lung The NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) began its activities back in November 2004 and developed clear objectives and strategies on how to begin ... Bigbee, William L.
Standard Specimen Reference Set: Pancreatic The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens ... Brand, Randall E.
Standard Specimen Reference Set: Prostate To collect biologic samples on men prior to prostate biopsy, in association with clinical information and common data elements appropriate for evaluation of ... Sanda, Martin
Standard Specimen Reference Set: Colon The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, ... Brenner, Dean
Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates Li, Christopher
T2-Erg Team Project Prostate cancer (PCa) is the third leading cause of cancer-related deaths among United States men, accounting for 33% of such diagnosed cancers.(1) An ... Sanda, Martin
Tamoxifen and Second Breast Cancer: Epidemiology/Pathology The BRITE Study (Breast Cancer Research Investigation of Treatment Effects) is a five-year, population-based nested case-control study, funded by the National ... Li, Christopher
Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict ... Markowitz, Sanford
The Biomarker Knowledge System Informatics Pilot Project Supplement To The Biomarker Development Laboratory at Moffitt (Bedlam) The Biomarker Knowledge System Informatics Pilot Project goal will develop network interfaces among databases that contain information about existing clinical ... Tockman, Melvyn S.
The Early Detection Research Network: Biomarker Reference Laboratories Chia, David
The Prostate Tumor Microenvironment Exhibits differentially expressed Genes Useful for Diagnosis To develop a multi-site prospective clinical validation trial of the multigene diagnostic signature for the diagnosis of prostate cancer from non tumor ... Mercola, Dan
Triple Negative Breast Cancer Team Project Early diagnosis of triple negative breast cancer would likely have significant impact on overall breast cancer mortality. This proposal is designed to ... Anderson, Karen
US-Turkey Cappadocia Mesothelioma Project Study never launched. Pass, Harvey Ira
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer BACKGROUND: Lung cancer is the leading cause of cancer deaths worldwide. New diagnostics are needed to detect early stage lung cancer because it may be cured ... Ostroff, Rachel
Upgrading Reference Set Thompson, Ian M.
Use of Exogenous Progestins and Risk of In Situ and Invasive Breast Cancer The SHARE II Study (Seattle Area Hormone And Reproductive Epidemiology Breast Cancer Study) is a 6 year grant funded by the Breast Cancer Research Program of ... Li, Christopher
Using MALDI-IMS and MRM to stablish a pipeline for discovery and validation of tumor neovasculature biomarker candidates. In an effort to circumvent the limitations associated with biomarker discovery workflows involving cell lines and cell cultures, histology-directed MALDI ... Gambhir, Sanjiv
Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population Pass, Harvey Ira
Validation of Autoantibodies as Biomarkers of Breast Cancer Anderson, Karen
Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010) We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ... Brenner, Dean
Validation of Early Detection Ovarian Cancer Biomarkers (Team Project) Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ... Skates, Steven
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) The goal of this collaborative group study is to improve the diagnostic evaluation of patients with indeterminate pulmonary nodules by determining whether ... Spira, Avrum
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques 1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ... Hanash, Samir
Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early ... Volk, Michael L.
Validation of [-2]proPSA for the Early Detection of Prostate Cancer Primary Objective – To validate the serum %[-2]proPSA marker for the improvement of diagnosis and risk assessment of prostate cancer and reducing unnecessary ... Chan, Daniel
Validation of the Mutagen Sensitivity and Chromosomal Hotspot Assays Spitz, Margaret R.
William Grady OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ... Grady, William
Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.