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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
SELDI Phase I: Assay Validation-Prostate It is then the goal of this collaborative project – EDRN-Prostate-SELDI Investigational Collaboration (EPSIC) - to use state-of-the-art protein profiling ... Semmes, John
SELDI Profiling of serum and urine from patients with urologic disease in support of bladder cancer studies Semmes, John
SELDI Validation Study Phase II This project –A Comprehensive Program for the Validation of Prostate Cancer Early Detection with Novel Protein Identification Techniques -- is divided into ... Semmes, John
SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas Semmes, John
SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study Create a new set of phase II specimens (160 cases with pre-operative bloods representing major histologic types and including 80 early-staged and 80 ... Cramer, Daniel
San Antonio Center of Biomarkers of Risk for Prostate Cancer (SABOR) To determine if there are ways to predict which men will get prostate cancer, if there are ways to predict how a prostate cancer will develop (for example, ... Thompson, Ian M.
Screen Detection of Mismatch Repair Deficient Colorectal Neoplasias Using a Stool Based DNA Analysis Lynch, Henry
Soluble Mesothelin Related Peptide (SMRP) and Osteopontin (OPN) as Early Detection Markers for Malignant Mesothelioma (MM) Phase I: - Identification and assemblage of representative cohorts of individuals with MM, no malignancies but increased risk for MM due to asbestos exposure, ... Pass, Harvey Ira
Spectral Markers for Early Detection of Colon Neoplasia Roy, Hemant K.
Standard Specimen Reference Set: Breast The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ... Marks, Jeffrey
Standard Specimen Reference Set: Liver Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC Volk, Michael L.
Standard Specimen Reference Set: Lung The NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) began its activities back in November 2004 and developed clear objectives and strategies on how to begin ... Bigbee, William L.
Standard Specimen Reference Set: Pancreatic The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens ... Brand, Randall E.
Standard Specimen Reference Set: Prostate To collect biologic samples on men prior to prostate biopsy, in association with clinical information and common data elements appropriate for evaluation of ... Sanda, Martin
Standard Specimen Reference Set: Colon The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, ... Brenner, Dean
Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates Li, Christopher
Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict ... Markowitz, Sanford
The Biomarker Knowledge System Informatics Pilot Project Supplement To The Biomarker Development Laboratory at Moffitt (Bedlam) The Biomarker Knowledge System Informatics Pilot Project goal will develop network interfaces among databases that contain information about existing clinical ... Tockman, Melvyn S.
The Early Detection Research Network: Biomarker Reference Laboratories Chia, David
The Prostate Tumor Microenvironment Exhibits differentially expressed Genes Useful for Diagnosis To develop a multi-site prospective clinical validation trial of the multigene diagnostic signature for the diagnosis of prostate cancer from non tumor ... Mercola, Dan
Triple Negative Breast Cancer Team Project Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ... Anderson, Karen
US-Turkey Cappadocia Mesothelioma Project Study never launched. Pass, Harvey Ira
Upgrading Reference Set We are proposing a multi-institutional study to identify molecular biomarkers and clinical measures that will predict presence of Gleason 7 or higher cancer ... Thompson, Ian M.
Using MALDI-IMS and MRM to stablish a pipeline for discovery and validation of tumor neovasculature biomarker candidates. In an effort to circumvent the limitations associated with biomarker discovery workflows involving cell lines and cell cultures, histology-directed MALDI ... Gambhir, Sanjiv
Using the methylome to identify aggressive Barrett’s esophagus OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ... Grady, William
Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population A prospective study to evaluate the utility of various biomarkers in the context of an MM Early Detection Program. The study cohort will be composed of workers ... Pass, Harvey Ira
Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010) We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ... Brenner, Dean
Validation of Early Detection Ovarian Cancer Biomarkers (Team Project) Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ... Skates, Steven
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) To characterize intra or within subject reproducibility and variability To characterize inter or across subject variability by adenoma phenotype (normal vs. ... Spira, Avrum
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques 1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ... Hanash, Samir
2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to http://grants.nih.gov /grants/guide/ pa-files/ PAR-15-289.html.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.