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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
Identification of New Markers in Normal and Abnormal Pap Smears Unger, Elizabeth R.
Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. BACKGROUND: Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans die of this ... Anglim, Paul
Identification of biomarkers for lung cancer in never smokers The overall goal of this project is to identify, verify and apply biomarkers for the early diagnosis or risk assessment of lung cancer in never smokers. The ... Gazdar, Adi
Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Gene expression profile analysis of lung cancers revealed the transactivation of an immunoglobulin-like molecule Nectin-4 in the majority of non-small cell ... Takano, Atsushi
Identification of protein and genetic biomarkers of prostate cancer and risk factors for progression of disease Thompson, Ian M.
Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis The detection of nonsmall cell lung cancer (NSCLC) at an early stage presents a daunting challenge due to the lack of a specific noninvasive marker. The ... Chen, Xi
In-depth proteomic analysis of non-small cell lung cancer to discover molecular targets and candidate biomarkers Advances in proteomic analysis of human samples are driving critical aspects of biomarker discovery and the identification of molecular pathways involved in ... Carbone, David P
Inflammation as a Potential Marker of Risk ad Progression for Prostate Cancer Thompson, Ian M.
Integrated Development of Novel Molecular Markers Sidransky, David
LIver Reference Set Applicant (Rapid) Beretta-FHCRC (2011) Beretta, Laura
LIver Reference Set Applicant (Rapid) Qu-Quest (2011) Qu, Kevin
LIver Reference Set Applicant (Rapid) Yamada - Wako (2011) Measure clinical effectiveness of AFP-L3 and DCP for early detection of HCC in patient samples collected prospectively during surveillance. However since such ... Yamada, Hiro
Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia Lynch, Henry
Liver Cancer Specimen Reference Set Application (Rapid): Giannelli - Univ of Bari (2008) To evaluate biomarker performance in an out-side cohort of LC and HCC patients Giannelli, Gianluigi
Liver Reference Set (Rapid) Norman (2012) Feng, Ziding
Liver Reference Set (Rapid) Norman-INOVA (2012) Feng, Ziding
Liver Reference Set Applicant (Full): Lubman - Univ of Michigan (2011) Lubman, David
Liver Reference Set Applicant (Full): Yamada - Wako (2011) Yamada, Hiro
Liver Reference Set Applicant (Rapid #1): Lubman - Univ of Michigan (2009) We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ... Lubman, David
Liver Reference Set Applicant (Rapid #2) Beretta-FHCRC (2011) Beretta, Laura
Liver Reference Set Applicant (Rapid #2): Lubman - Univ of Michigan (2010) We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ... Lubman, David
Liver Reference Set Application (Full): Block - Drexel Univ (2010) The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ... Block, Timothy
Liver Reference Set Application (Rapid): Block - Drexel Univ (2008) The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ... Block, Timothy
Lung A Reference Set (Full) Applicant: Coverley-York (2011) Coverley, Dawn
Lung C Reference Set (Full): Rachel Ostroff - SomaLogics (2010) Analysis of the EDRN lung biomarker samples will enable the next step in development of a clinical diagnostic assay for the differential diagnosis of lung ... Ostroff, Rachel
Lung Cancer Specimen Reference Set A (Full) Application: Goodglick/Diamandis (2009) To study of the utility of KLK8, 11, 12, 13, and 14 profiles in diagnosing lung cancer. Chia, David
Lung Cancer Specimen Reference Set A (Full) Application: Hirschowitz - University of Kentucky (2009) We are continuing validation with two advanced objectives: 1) To evaluate assay performance for established lung cancer diagnosed in a clinical population 2) ... Hirschowitz, Edward
Lung Reference Set A (Full) Applicant: Takacs - Biosystems (2010) Not listed
Lung cancer diagnosis from proteomic analysis of preinvasive lesions. Early detection may help improve survival from lung cancer. In this study, our goal was to derive and validate a signature from the proteomic analysis of ... Rahman, Jamshedur S.M.
MALDI Dilution Data: Randolph Feng, Ziding
Announcement 11/20/2014

New Round of EDRN FOAs

The RFAs for EDRN have been released:
- Biomarker Developmental Laboratories (U01),
- Clinical Validation Centers (U01),
- Biomarker Reference Laboratories (U24),
- Data Management and Coordinating Center (U24).

EDRN Renewal flyer NOTE-New receipt deadline for applications submitted for all EDRN FOAs is January 20, 2015, by 5:00 PM local time of applicant organization.

There will be a Pre-Application webinar to discuss each of the four individual EDRN FOAs on Tuesday, December 2nd, 2014, from 1pm-5pm (Eastern). Potential applicants interested in participating in the webinar should send a message to Dr. Sharmistha Ghosh (ghoshjanjigias@mail.nih.gov) no later than 5:00 p.m. (EST) November 21, 2014. Please mention the FOA of interest in the subject line.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.