Seattle Area Hormone and Reproductive Epidemiology Breast Cancer Study
No involved investigator sites defined.
The SHARE Study (Seattle Area Hormone And Reproductive Epidemiology Breast Cancer Study) is a five-year, population-based case-control study, funded by the National Institutes of Health, to investigate the relationship between hormone replacement therapy (HRT) and invasive lobular and invasive ductal breast cancer among women 55 to 74-years of age. The case group of 1043 women consists of 271 invasive lobular, 330 invasive ductal and lobular, and 442 invasive ductal, breast cancer cases. The control group consists of 469 controls drawn from the general population. The specific study hypotheses that were tested: 1. Is the use of combined estrogen-progestin hormone replacement therapy (CHRT) associated with an increase in the incidence of invasive lobular breast cancer in women aged 55-74a 2. Is the use of CHRT associated with an increase in the incidence of invasive ductal breast cancer in women aged 55-74a 3. Does the duration, patterns and/or recency of CHRT use influence the size of the associationa 4. Is the use of CHRT associated with particular tumor marker profiles or characteristics of lobular and ductal breast cancers
There are currently no biomarkers annotated for this protocol.
No datasets are currently associated with this protocol.