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Not an EDRN Protocol

A comparison of cytology and fluorescence in situ hybridization for the detection of lung cancer in bronchoscopic specimens

1000
Halling, Kevin CMayo Clinic
Halling, Kevin CMayo Clinic
5p15

To determine the relative sensitivity and specificity of cytology and fluorescence in situ hybridization (FISH) for the detection of lung cancer in bronchoscopically obtained specimens. Cytology and FISH were performed on brushing and washing specimens obtained from patients undergoing bronchoscopy for suspected lung cancer. FISH utilized the LAVysion probe set (Abbott Molecular; Des Plaines, IL), which contains locus-specific probes to 5p15, 7p12 (EGFR), 8q24 (C-MYC), and a centromeric probe to chromosome 6. These findings show that FISH is significantly more sensitive than conventional cytology for detecting lung cancer in bronchial brushing specimens; when combined with cytology, FISH can improve the diagnostic sensitivity of detecting malignancy in bronchial brushing and washing specimens.

There are currently no biomarkers annotated for this protocol.

No datasets are currently associated with this protocol.


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The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

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Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html