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Assay of TMPRSS2:ERG and PCA in Canary PASS

368

No involved investigator sites defined.

Urinary PCA3 and TMPRSS2:ERG
Proteomics
Prostate and Urologic Cancers Research Group
2

The identification of biomarkers that, at the time of diagnosis, associate with the presence of, or progression to, aggressive prostate cancer will transform the clinical management of this malignancy. If patients and their physicians have reliable and valid tools for estimating the risk of disease-specific morbidity, then more patients might opt for and adhere to active surveillance regimens, and consequently reduce overtreatment and the attendant substantial costs and harms. Also, a marker or marker panel with high accuracy for progression on active surveillance will identify those men who could be placed on less intensive surveillance protocols with fewer repeated prostate biopsies, reducing the risks and costs of invasive procedures. The study presented here is a step toward validating such biomarkers.

1.   Assess the frequency of TMPRSS2:ERG gene-fusion in whole urines of an active surveillance population. 2.   Evaluate urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression. 3.   Evaluate longitudinal changes in urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression.
Gen-Probes TMA assay

There are currently no biomarkers annotated for this protocol.

No datasets are currently associated with this protocol.


Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.

Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html