Early Detection Research Network

Biomarker Detection Using NAPPA Tumor Antigen Arrays: EDRN Supplement

PI: Anderson, Karen

The overall goal of this project application for the EDRN set-aside funds is to focus our collaborative efforts to identify p53 mutation-specific antibody ...

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Discovery for Renal Cell Carcinoma Through Serum, Urine and Tissue Protein Profiles

PI: Basler, Joseph W.

Biomarkers for Prostate and Bladder Cancer

PI: Liu, Alvin Y.

CD26+ cancer cells and CD90+ tumor-associated stromal cells were sorted from tumor tissue. Dataset analysis with transcriptomes of CD26+ luminal, CD104+ basal, ...

Body Fluids as a Source of Diagnostic Biomarkers

Body Fluids as a Source of Diagnostic Biomarkers: Prostate

Chemokine Prostate Cancer Biomarkers

Recent advances in high-throughput protein expression profiling of bodily fluids has generated great enthusiasm and hope for this approach as a potent ...

Canary TMA

PI: Nelson, Peter S

PI: Macoska, Jill

STUDY DESIGN 1. The need for pre-validation studies. Preliminary data from our laboratory demonstrates a potential utility for CXCL5 and CXCL12 as biomarkers ...

Clinical Utility of Urinary CD90 as a Biomarker for Prostate Cancer Detection

PI: Liu, Alvin Y.

Tumor-associated stromal cells differ from normal gland-associated stromal cells in gene expression. Genes up-regulated in these stromal cells are potential ...

Detection of Bladder CA by Microsatellite Analysis (MSA)

PI: Schoenberg, Mark P.

Goal 1: To determine sensitivity and specificity of microsatellite analysis (MSA) of urine sediment, using a panel of 15 microsatellite markers, in detecting ...

Development and Clinical Validation of Biomarkers for Prostate Cancer

PI: Partin, Alan W

Development and Evaluation of a Tumor Marker for Prostate Cancer

PI: Partin, Alan W

Major strides in the early detection, staging, monitoring, and risk stratification of men with prostate cancer have been realized over the last few decades. ...

EDRN Pre-Validation of Metabolic Biomarkers of Prostate Cancer: Follow up EDRN Challenge

PI: Chinnaiyan, Arul M.

The goal of this EDRN set-asides proposal is to carry out pre-validation studies on sarcosine as a metabolomic biomarker of prostate cancer in urine. Not only ...

EDRN Pre-Validation of Multiplex Biomarker in Urine

PI: Chinnaiyan, Arul M.

The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in ...

Early Detection of Cancer by Affinity Mass Spectrometry-Set Aside funds

Early Detection of Urinary Bladder Cancer

A. RATIONALE The recent introduction of multiple reaction monitoring capabilities offers unprecedented capability to the research arsenal available to ...

Early Molecular Detection of Invasive Bladder Cancer by Urine Examination

Establishment of a serum standard for use in high-throughput proteomic

Glycoprotein Biomarkers for the Early Detection of Aggressive Prostate Cancer

PI: Zhang, Hui L.

The Early Detection Research Network of the NCI is charged with the discovery, development and validation of biomarkers for early detection and prognosis ...

Identification of protein and genetic biomarkers of prostate cancer and risk factors for progression of disease

Inflammation as a Potential Marker of Risk ad Progression for Prostate Cancer

Integrated Development of Novel Molecular Markers

PI: Sidransky, David

Methylation & Proteomics-Based Detection of Bladder Cancer

PI: Cairns, Paul

To determine sensitivity and specificity of quantitative real-time methylation specific PCR (qMSP) of urine sediment DNA, using a panel of several methylated ...

Molecular Genetics of Urinary Bladder Carcinoma

Molecular Progression of Methylation in Bladder Cancer

PI: Sidransky, David

Ornithine decarboxylase (ODC) Polymorphism and Breast and Prostate Cancer

PI: Helzlsouer, Kathy

PCA3 Validation Study and Urinary Reference Set

PI: Wei, John

Independent of serum PSA level, PCA3 score will refine the risk of having cancer detected on an extended template prostate biopsy.

Pre-Validation of Metabolomic Biomarkers of Prostate Cancer

PI: Chinnaiyan, Arul M.

Prostate Active Surveillance Study

PI: Lin UW, Daniel W.

Canary PASS is a multi-center, prospective active surveillance study with selective intervention in patients with previously untreated, clinically localized ...

Prostate Rapid Pre-Validation Set

PI: Wagner, Andrew

Determine which markers move to validation using the prospectie prostate reference set samples.

Prostate Rapid Reference Set Applicant: Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Prostate Rapid Reference Set Application: Haab - Van Andel (2006)

PI: Haab, Brian

To evaluate TSP-1 as a marker to specifically detect prostate cancer

Prostate Rapid Reference Set Application: Chan/Beckman Coulter (2007)

PI: Chan, Daniel

Evaluate performance of [-2]proPSA as an early detection marker for prostate cancer

Prostate Rapid Reference Set: Getzenberg - Johns Hopkins (2006)

PI: Getzenberg, Robert H.

Analyze marker EPCA2 on 123 observations (60 prostate cancers and 63 non-prostate cancers)

Prostate Specimen Ref Set Applicant: Isaacs-JHU-2010

PI: Isaacs, William

Can SNP genotyping assist in the prediction of biopsy results for prostate cancer.

Prostate Upgrading Team Project

Prostate-Specific Glycoproteins for Early Detection of Prostate Cancer

PI: Zhang, Hui L.

Release of Set Aside Funds - microRNA Biomarkers for Renal Cell Carcinoma

SELDI Phase I: Assay Validation-Prostate

SELDI Profiling of serum and urine from patients with urologic disease in support of bladder cancer studies

It is then the goal of this collaborative project – EDRN-Prostate-SELDI Investigational Collaboration (EPSIC) - to use state-of-the-art protein profiling ...

SELDI Validation Study Phase II

San Antonio Center of Biomarkers of Risk for Prostate Cancer (SABOR)

This project –A Comprehensive Program for the Validation of Prostate Cancer Early Detection with Novel Protein Identification Techniques -- is divided into ...