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Biomarkers
Bajtarevic VOCs signature
Exhaled breath was collected and differences in concentration for more than 50 volatile organic compounds (VOCs) was assayed by various methods.
Tanaka Circulating Tumor Cells (CTCs)
Circulating tumor cells (CTC) can be found and quantitatively evaluated with a semiautomated system (CellSearch) in patients with primary lung cancer. CTC ...
5p15
Locus 5p15 has been identified as a region of lung cancer susceptibility through genome-wide association studies.
Garcia chromosomal aneusomy + cytology
Fluorescence in situ hybridization (FISH) assay is used to monitor levels of chromosome copies in interphase cells. Multicolor FISH proes simultaneously ...
KCNH5
KCNH5 is a member of the potassium channel, voltage-gated, subfamily H family of voltage-gated potassium channels. The voltage-gated potassium channels are a ...
MTHFR
The MTHFR gene product catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to ...
SHOX2
SHOX2 is a member of the homeobox family of genes. These genes are transcriptional regulators involved in pattern formation in both invertebrate and ...
LOC147166
Massion CEP6 + sputum cytology + demographics
CEP6 is the designation for the centromere region of chromosome 6. Amplification of this region has been identified in lung cancer.
CEP6
CEP6 is the designation for the centromere region of chromosome 6. Amplification of this region has been linked to presence or development of lung cancer.
FGF2
FGF2, also known as bFGF, is a member of the fibroblast growth factor family. These family members play an important role in the regulation of cell survival, ...
BVES
The BVES gene encodes a protein that is a member of the POP family and is thought to contain three transmembrane domains. The protein is a cell adhesion ...
CEP3
CEP3 is the designation for the centromere region of chromosome 3. Amplification of this region has been identified in lung cancer.
TNFRSF25
The TNFRSF25 gene product is a member of the TNF-receptor superfamily. TNFRSF25 protein is a receptor for TNFSF12/APO3L/TWEAK. It mediates activation of ...
Philips VOCs signature
A combination of 22 breath volatile organic compounds (VOCs), predominantly alkanes, alkane derivatives, and benzene derivatives, that can discriminate between ...
Showe 29-gene signature for lung cancer
A 29-gene peripheral blood gene expression signature that separates patients with non-small cell lung cancer (NSCLC) tumors and patient controls with 86% ...
PTPRN2
PTPRN2 is a member of the protein tyrosine phosphatase (PTP) family. These proteins are signaling molecules that regulate a variety of cellular processes ...
Chen 10-marker miRNA signature for non-small cell lung cancer
A panel of 10 serum miRNAs has been identified that were found to have significantly different expression levels in non-small cell lung cancer (NSCLC) ...
14-3-3 theta
14-3-3 theta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved ...
ANG
Angiogenin, or ANG, is a mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to ...
Boeri miRNA signature of diagnosis of lung cancer
miRNA expression analyses in plasma samples collected 1ÃÆ'¢â‚¬â€œ2 y before the onset of disease, at the time of CT ...
Halling 4-marker LAVysion lung cancer probe set
This panel is comprised of the commercially available LAVysion probe set, Abbott Molecular, Des Plaines, IL. This panel was used by Halling, et al, to compare ...
Bianchi 34-marker miRNA Signature for Lung Cancer
This signature was developed based on the detection of 34 microRNAs (miRNAs) from serum that could identify patients with early stage non-small cell lung ...
8q24 (C-MYC)
Chromosome region 8q24 contains the gene for MYC, also known as C-MYC. MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle ...
Boeri miRNA signature of risk for lung cancer
miRNA expression analyses in plasma samples collected 1ÃÆ'¢â‚¬â€œ2 y before the onset of disease, at the time of CT detection ...
TP63
TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many ...
TNF
TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and ...
Shen 4-marker miRNA panel for lung cancer
We initially validated expressions of a set of miRNAs in paired lung tumor tissues and plasma specimens from 28 stage I NSCLC patients by real-time ...
CYFRA 21-1
CYFRA 21-1 is a test measuring a cytokeratin-19 fragment that is soluble in human serum and may be a useful circulating tumor marker. The test was developed ...
Massion 4-marker FISH panel for lung cancer
The combination of these 4 probes, TP63, MYC, CEP3, and CEP6, offered a sensitivity of 82% for lung cancer and a specificity of 58%. These results indicate ...
OPCML
The OPCML protein is a member of the IgLON subfamily in the immunoglobulin protein superfamily. OPCML binds opioids in the presence of acidic lipids. The ...
RPSA
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide ...
RARB
The RARB gene encodes the retinoic acid receptor beta. It is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional ...
PAX8
The PAX8 gene product is a member of the paired box (PAX) family of transcription factors. It is a transcription factor for the thyroid-specific expression of ...
Hanash 3-marker panel for Lung Cancer
The EDRN validation study ("Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques") presents evidence for the occurrence in ...
VEGFA
Vascular endothelial growth factor (VEGFA or VEGF) is a growth factor and signaling protein involved in the regulation of angiogenesis, vasculogenesis, and ...
Annexin 1
Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. ...
CEACAM5
CEA is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. It is a receptor for E.coli Dr adhesins.
Pecot MALDI MS signature + clinical and imaging data
A serum proteomic signature of seven features identified by MALDI MS was previously identified (see "Yildiz MALDI MS signature for lung cancer"). The serum ...
PARK7
DJ-1, also known as PARK-7, belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It ...
7p12 (EGFR)
Chromosome region 7p12 contains the EGFR gene. Copy number gains in this chromosome region have been implicated in lung cancer.
GDNF
The GDNF gene encodes a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons. This protein is a mature ...
Spira 80-marker panel for lung cancer
This 80-gene biomarker panel is used to distinguish smokers with lung cancer from smokers without lung cancer. The biomarker panel had approximately 90% ...
MYC
The oncogenic protein MYC, previously known as c-MYC, is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and ...
UCHL1
PGP9.5, also called Ubiquitin-protein hydrolase (UCHL1), is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to ...
Projects/Protocols

Projects

There are currently no projects of which this group is a part.

Protocols

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer

PI: Tainsky, Michael A.

Our long term goal is to improve survival of patients with head and neck squamous cell carcinoma (HNSCC) through early detection using simple noninvasive serum ...

Biomarker Dev Lab At Moffitt Supplement

PI: Tockman, Melvyn S.

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non- progressing cancers

PI: Rom, William

We hypothesize that our novel Biomarker Panel of Auto-antibodies can distinguish aggressive, symptom diagnosed lung cancer from non-aggressive, screen-detected ...

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Collaborative study on SELDI biomarker discovery and serum protein profiling of lung cancers

PI: Semmes, John

Dubinett - Targeted Sequencing 2012

PI: Dubinett, Steve

we propose to use targeted massively parallel DNA sequencing to identify somatic alterations within mutational hotspots in matched sets of primary lung tumors, ...

Ecogenetic Study of Lung Cancer

PI: Spitz, Margaret R.

Identification of biomarkers for lung cancer in never smokers

PI: Gazdar, Adi

The overall goal of this project is to identify, verify and apply biomarkers for the early diagnosis or risk assessment of lung cancer in never smokers. The ...

Integrated Development of Novel Molecular Markers

PI: Sidransky, David

Lung A Reference Set (Full) Applicant: Coverley-York (2011)

PI: Coverley, Dawn

Lung C Reference Set (Full): Rachel Ostroff - SomaLogics (2010)

PI: Ostroff, Rachel

Analysis of the EDRN lung biomarker samples will enable the next step in development of a clinical diagnostic assay for the differential diagnosis of lung ...

Lung Cancer Specimen Reference Set A (Full) Application: Goodglick/Diamandis (2009)

PI: Chia, David

To study of the utility of KLK8, 11, 12, 13, and 14 profiles in diagnosing lung cancer.

Lung Cancer Specimen Reference Set A (Full) Application: Hirschowitz - University of Kentucky (2009)

PI: Hirschowitz, Edward

We are continuing validation with two advanced objectives: 1) To evaluate assay performance for established lung cancer diagnosed in a clinical population 2) ...

Lung Reference Set A (Full) Applicant: Takacs - Biosystems (2010)

NYU Lung Cancer Biomarker Center

PI: Rom, William

A. SPECIFIC AIMS 1. To develop and prospectively follow a large cohort at high-risk for lung cancer. Individuals are recruited to one of two different ...

New Biomarkers & Dysplastic Respiratory Epithelium

PI: Franklin, Wilbur Alan

Proteomic Approach for Diagnostic Applications in Head and Neck Cancer

PI: Tainsky, Michael A.

To evaluate the test characteristics of a panel of biomarkers for identifying patients with early stage head and neck squamous cell carcinoma (HNSCC). The ...

Protocol for Comparing Promoter Hypermethylation Methods in NSCLC

PI: Tockman, Melvyn S.

Soluble Mesothelin Related Peptide (SMRP) and Osteopontin (OPN) as Early Detection Markers for Malignant Mesothelioma (MM)

PI: Pass, Harvey Ira

Phase I: - Identification and assemblage of representative cohorts of individuals with MM, no malignancies but increased risk for MM due to asbestos exposure, ...

Standard Specimen Reference Set: Lung

PI: Bigbee, William L.

The NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) began its activities back in November 2004 and developed clear objectives and strategies on how to begin ...

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

US-Turkey Cappadocia Mesothelioma Project

PI: Pass, Harvey Ira

Study never launched.

Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population

PI: Pass, Harvey Ira

Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)

PI: Spira, Avrum

The goal of this collaborative group study is to improve the diagnostic evaluation of patients with indeterminate pulmonary nodules by determining whether ...

Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques

PI: Hanash, Samir

1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ...

Validation of the Mutagen Sensitivity and Chromosomal Hotspot Assays

PI: Spitz, Margaret R.

Data
Identification of biomarkers for lung cancer in never smokers
In-depth proteomic analysis of non-small cell lung cancer to discover molecular targets and candidate biomarkers
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques
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Past Events

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Documents
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