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Biomarkers

There are currently no biomarkers defined for this collaborative group.

Projects/Protocols

Projects

Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)

PI: Schoen, Robert E.

Investigators in the colon section of EDRN have a mutual interest in developing markers that would identify individuals at increased risk for colon neoplasia. ...

Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)

PI: Brenner, Dean

1   AIMS We propose a GI Collaborative biomarker validation project with the goal of identifying those biomarkers developed by the GI collaborative that will ...

Protocols

Affinity-based strategies to fast track development of colon cancer biomarkers

PI: Lampe, Paul

Our goal is to discover plasma and tissue-based tumor biomarkers that work well enough together to identity colon cancer at early stages, lead to accurate ...

Barrett's Esophagus Methylation Profiles

PI: Meltzer, Stephen

We propose a nested case-control study of biomarkers in the setting of BE. By bringing together research institutions with large populations of patients with ...

Biomarkers for early detection of pancreatic cancer

PI: Lokshin, Anna

Background: The clinical management of pancreatic cancer is severely hampered by the absence of effective screening tools. Methods: Sixty-seven biomarkers ...

Biomarkers for the Early Detection of Pancreatic Cancer

PI: Killary, Ann M.

Biomarkers of Risk for Colorectal Neoplasia

PI: Schoen, Robert E.

To explore biomarkers of risk of adenoma and adenoma recurrence

Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)

PI: Schoen, Robert E.

Investigators in the colon section of EDRN have a mutual interest in developing markers that would identify individuals at increased risk for colon neoplasia. ...

Breast Ref Applicant: Mukherhjee-CanDiag (2014)

PI: Mukherhjee, Pinku

Breast Ref Applicant: Mukherjee 2014

PI: Mukherhjee, Pinku

Breast Reference Set Application: Pinku Mukherhjee-CanDiag (2014)

PI: Mukherhjee, Pinku

Breast Reference Set Application: Pinku Mukherjee-CanDiag (2014)

PI: Mukherhjee, Pinku

We would like to get all three sets of specimens, however, we are requesting Specimen Set 1 first: 30 subjects with invasive cancer and 30 subjects with benign ...

Clinical and Analytical Validation of Cancer Biomarkers: Developmental Studies

PI: Chan, Daniel

Colon Reference Set Application: Robert Getzenberg - Johns Hopkins (2008)

PI: Getzenberg, Robert H.

The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and ...

Colon Cancer Specimen Reference Set Application: Disis - University of Washington (2008)

PI: Disis, Mary L

The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a ...

Colon Cancer Specimen Reference Set Application: Getzenberg - Johns Hopkins (2008)

PI: Getzenberg, Robert H.

The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and ...

Colon Cancer Specimen Reference Set Application: Jendoubi - Milagen (2006)

PI: Jendoubi, Moncef

No Data Received at DMCC

Colon Cancer Specimen Reference Set Application: Kim - DiaDexus (2008)

PI: Kim, Nam

Colon Reference Set Application: Mary Disis - University of Washington (2008)

PI: Disis, Mary L

The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a ...

Colon Reference Set Application: Moncef Jendoubi - Milagen (2006)

PI: Jendoubi, Moncef

Confidential

Colon Reference Set Application: Nam Kim - DiaDexus (2008)

PI: Kim, Nam

The EDRN Colorectal reference samples will be useful in confirming the potential application of novel serum markers for colorectal cancer that can detect ...

Detection of cancer DNA markers in urine

PI: Block, Timothy

Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers

PI: Gambhir, Sanjiv

Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer

EDRN-WHI Pre-Clinical Colon Ca Specimens

PI: Hanash, Samir

Specifically, it is proposed to assess plasma proteins from postmenopausal women diagnosed with colon cancer within a span of 18 months after year-3 OS blood ...

Early Detection and Prognosis of Hepatocellular Carcinoma

PI: Volk, Michael L.

Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies

PI: Hollingsworth, Michael

Determining and quantifying the types of mucin core proteins to which CA19-9 is attached will result in assays with improved performance characteristics ...

Early detection of liver cancer and hepatitis

PI: Block, Timothy

GLNE 003: Preliminary Validation of Biomarkers Predictive of Barrett’s Esophagus Progression to Dysplasia and Adenocarcinoma

PI: Brenner, Dean

   Recognizing that novel potential biomarkers are continually being identified and will need to be validated in a rapid, efficient, and scientifically ...

HNPCC colon cancer-associated SELDI mass spectrometry protein profiles in serum

PI: Lynch, Henry

Hepatocellular carcinoma Early Detection Strategy study

PI: Marrero, Jorge

Part 1: The first part of this study is to conduct follow-up for patients that were enrolled in the EDRN Phase 2 Validation Study called DCP (13). For this ...

Hereditary Cancer Institute family study specimen bank

PI: Lynch, Henry

Hollingsworth - Aggressive vs Indolent 2012

PI: Hollingsworth, Michael

Study Overview. We will examine DNA extracted from FFPE sections from approximately 200 different surgically resected primary pancreatic tumors from the UNMC ...

Hollingsworth - Aggressive vs Indolent 2012 (357)

PI: Hollingsworth, Michael

Study Overview. We will examine DNA extracted from FFPE sections from approximately 200 different surgically resected primary pancreatic tumors from the UNMC ...

Hollingsworth - Aggressive vs Indolent 2012 (359)

PI: Hollingsworth, Michael

LIver Reference Set Applicant (Rapid) Beretta-FHCRC (2011)

PI: Beretta, Laura

LIver Reference Set Applicant (Rapid) Qu-Quest (2011)

PI: Qu, Kevin

LIver Reference Set Applicant (Rapid) Yamada - Wako (2011)

PI: Yamada, Hiro

Measure clinical effectiveness of AFP-L3 and DCP for early detection of HCC in patient samples collected prospectively during surveillance. However since such ...

Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia

PI: Lynch, Henry

Liver Cancer Specimen Reference Set Application (Rapid): Giannelli - Univ of Bari (2008)

PI: Giannelli, Gianluigi

To evaluate biomarker performance in an out-side cohort of LC and HCC patients

Liver Full Reference Set Application :Timothy Block - Drexel Univ (2010)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Full Reference Set Application: David Lubman - Univ of Michigan (2011)

PI: Lubman, David

In this work we will perform the next step in the biomarker development and validation. This step will be the Phase 2 validation of glycoproteins that have ...

Liver Full Reference Set Application: Hiro Yamada - Wako (2011)

PI: Yamada, Hiro

Wako has received new 510(k) clearance for Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) and Des-gamma-carboxy prothrombin (DCP) ...

Liver Rapid Reference Set Application ( #2): Lubman - Univ of Michigan (2010)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Rapid Reference Set Application (#1): David Lubman - Univ of Michigan (2009)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Rapid Reference Set Application (#1): Laura Beretta-FHCRC (2011)

PI: Beretta, Laura

Test 2 candidate biomarkers for early detection of HCC. Marker S and Marker L.

Liver Rapid Reference Set Application (#2): Laura Beretta-FHCRC (2011)

PI: Beretta, Laura

Test 2 candidate biomarkers for early detection of HCC. Marker S and Marker L.

Liver Rapid Reference Set Application: Gary Norman-INOVA (2012)

PI: Norman, Gary L.

We have developed a new and novel assay for the detection of Golgi protein 73 (GP73), also known as Golgi membrane protein 1 (Golm1) or Golgi phosphoprotein 2 ...

Liver Rapid Reference Set Application: Gianluigi Giannelli - Univ of Bari (2008)

PI: Giannelli, Gianluigi

To evaluate biomarker performance in an out-side cohort of LC and HCC patients

Liver Rapid Reference Set Application: Hiro Yamada - Wako (2011)

PI: Yamada, Hiro

Liver Rapid Reference Set Application: Hiro Yamada - Wako (2011)

PI: Yamada, Hiro

Measure clinical effectiveness of AFP-L3 and DCP for early detection of HCC in patient samples collected prospectively during surveillance. However since such ...

Liver Rapid Reference Set Application: Kevin Qu-Quest (2011)

PI: Qu, Kevin

We propose to evaluate the performance of a novel serum biomarker panel for early detection of hepatocellular carcinoma (HCC). This panel is based on markers ...

Liver Rapid Reference Set Application: Timothy Block - Drexel Univ (2008)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Reference Set (Rapid) Norman (2012)

PI: Feng, Ziding

Liver Reference Set (Rapid) Norman-INOVA (2012)

PI: Feng, Ziding

Liver Reference Set Applicant (Full): Lubman - Univ of Michigan (2011)

PI: Lubman, David

Liver Reference Set Applicant (Full): Yamada - Wako (2011)

PI: Yamada, Hiro

Liver Reference Set Applicant (Rapid #1): Lubman - Univ of Michigan (2009)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Reference Set Applicant (Rapid #2) Beretta-FHCRC (2011)

PI: Beretta, Laura

Liver Reference Set Applicant (Rapid #2): Lubman - Univ of Michigan (2010)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Reference Set Application (Full): Block - Drexel Univ (2010)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Reference Set Application (Rapid): Block - Drexel Univ (2008)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Reference Set Application :Timothy Block - Drexel Univ (2010)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Reference Set Application: David Lubman - Univ of Michigan (2011)

PI: Lubman, David

MMR protein expression in HNPCC

PI: Lynch, Henry

Methylation tumor markers in HNPCC

PI: Lynch, Henry

Molecular Basis of Barrett's -Associated Carcinogenesis

PI: Stass, Sanford

Mutational load distribution analysis (MLDA) in pancreatic cancer

PI: Lynch, Henry

Certain p16 mutation carriers showed mutation elevations in the specific Ki-ras and p53 alleles significantly higher than normal, similar to controls with ...

Novel Surveillance Strategies For Hereditary Nonpolyposis Colon Cancer Family Members

PI: Lynch, Henry

Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside)

PI: Lokshin, Anna

Pancreatic Cancer Reference Set Applicant: Honda (2014)

PI: Honda, Kazufumi

Pancreatic Cancer Reference Set Applicant: NCI Honda (2014)

PI: Honda, Kazufumi

Pancreatic Cystic Fluid Reference Set

PI: Brand, Randall E.

The proposed reference set will be designed to evaluate biomarkers for the following applications aimed at determining whether a patient would benefit from ...

Pancreatic Ref Set Applicant: Batra 2014

PI: Batra, Surinder

Pancreatic Ref Set Applicant: Hollingsworth 2014

PI: Hollingsworth, Michael

Pancreatic Reference Set Applicant-Haab (2012)

PI: Haab, Brian

This study will address the clinical problems of early detection and diagnosis. The samples were obtained from patients with early-stage pancreatic cancer, ...

Pancreatic Reference Set Applicant-Killary (2012)

PI: Killary, Ann M.

Pancreatic Reference Set Applicant: Blasutig 2014

PI: Blasutig, Ivan

Pancreatic Reference Set Application- Ann Killary-MD Anderson (2012)

PI: Killary, Ann M.

ELISA assays. We propose to screen a two gene panel (TNC/TFPI) from functional genomic pathways approaches, by ELISA assays, in a collection of blinded plasma ...

Pancreatic Reference Set Application: Brian Haab-Van Andel (2012)

PI: Haab, Brian

New markers are greatly needed for the detection and diagnosis of pancreatic cancer. Patients at high risk for developing pancreatic cancer (for, example ...

Pancreatic Reference Set Application: Ivan Blasutig-University of Toronto (2014)

PI: Blasutig, Ivan

Pancreatic Reference Set Application: Kazufumi Honda-National Cancer Center (2014)

PI: Honda, Kazufumi

Pancreatic Reference Set Application: Michael Hollingsworth-University of Nebraska (2014)

PI: Hollingsworth, Michael

Pancreatic Reference Set Application: Surinder Batra- University of Nebraska (2014)

PI: Batra, Surinder

Polyp Prediction Study

PI: Meltzer, Stephen

Preliminary Clinical Characterization of Serum Biomarkers for Colorectal Neoplasms

PI: Brenner, Dean

Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)

PI: Brenner, Dean

1   AIMS We propose a GI Collaborative biomarker validation project with the goal of identifying those biomarkers developed by the GI collaborative that will ...

Prognostic Markers in Lynch Syndrome Colorectal Cancers

PI: Lynch, Henry

Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers

PI: Semmes, John

Screen Detection of Mismatch Repair Deficient Colorectal Neoplasias Using a Stool Based DNA Analysis

PI: Lynch, Henry

Spectral Markers for Early Detection of Colon Neoplasia

Standard Specimen Reference Set: Liver

PI: Volk, Michael L.

Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC

Standard Specimen Reference Set: Pancreatic

PI: Brand, Randall E.

The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens ...

Standard Specimen Reference Set: Colon

PI: Brenner, Dean

The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, ...

Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis

PI: Markowitz, Sanford

Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict ...

Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010)

PI: Brenner, Dean

We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ...

Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma

PI: Volk, Michael L.

Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early ...

William Grady

PI: Grady, William

OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ...

Data
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