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Upcoming Events

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Biomarkers

There are currently no biomarkers defined for this collaborative group.

Projects/Protocols

Projects

Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)

PI: Schoen, Robert E.

Investigators in the colon section of EDRN have a mutual interest in developing markers that would identify individuals at increased risk for colon neoplasia. ...

Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)

PI: Brenner, Dean

1   AIMS We propose a GI Collaborative biomarker validation project with the goal of identifying those biomarkers developed by the GI collaborative that will ...

Protocols

Affinity-based strategies to fast track development of colon cancer biomarkers

PI: Lampe, Paul

Our goal is to discover plasma and tissue-based tumor biomarkers that work well enough together to identity colon cancer at early stages, lead to accurate ...

Barrett's Esophagus Methylation Profiles

PI: Meltzer, Stephen

We propose a nested case-control study of biomarkers in the setting of BE. By bringing together research institutions with large populations of patients with ...

Biomarkers for the Early Detection of Pancreatic Cancer

PI: Killary, Ann M.

Biomarkers of Risk for Colorectal Neoplasia

PI: Schoen, Robert E.

To explore biomarkers of risk of adenoma and adenoma recurrence

Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)

PI: Schoen, Robert E.

Investigators in the colon section of EDRN have a mutual interest in developing markers that would identify individuals at increased risk for colon neoplasia. ...

Clinical and Analytical Validation of Cancer Biomarkers: Developmental Studies

PI: Chan, Daniel

Colon Cancer Specimen Reference Set Application: Disis - University of Washington (2008)

PI: Disis, Mary L

The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a ...

Colon Cancer Specimen Reference Set Application: Getzenberg - Johns Hopkins (2008)

PI: Getzenberg, Robert H.

The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and ...

Colon Cancer Specimen Reference Set Application: Jendoubi - Milagen (2006)

PI: Jendoubi, Moncef

No Data Received at DMCC

Colon Cancer Specimen Reference Set Application: Kim - DiaDexus (2008)

PI: Kim, Nam

Detection of cancer DNA markers in urine

PI: Block, Timothy

Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers

PI: Gambhir, Sanjiv

Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer

EDRN-WHI Pre-Clinical Colon Ca Specimens

PI: Hanash, Samir

Specifically, it is proposed to assess plasma proteins from postmenopausal women diagnosed with colon cancer within a span of 18 months after year-3 OS blood ...

Early Detection and Prognosis of Hepatocellular Carcinoma

PI: Volk, Michael L.

Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies

PI: Hollingsworth, Michael

Determining and quantifying the types of mucin core proteins to which CA19-9 is attached will result in assays with improved performance characteristics ...

Early detection of liver cancer and hepatitis

PI: Block, Timothy

GLNE 003: Preliminary Validation of Biomarkers Predictive of Barrett’s Esophagus Progression to Dysplasia and Adenocarcinoma

PI: Brenner, Dean

   Recognizing that novel potential biomarkers are continually being identified and will need to be validated in a rapid, efficient, and scientifically ...

HNPCC colon cancer-associated SELDI mass spectrometry protein profiles in serum

PI: Lynch, Henry

Hepatocellular carcinoma Early Detection Strategy study

PI: Marrero, Jorge

Hereditary Cancer Institute family study specimen bank

PI: Lynch, Henry

Hollingsworth - Aggressive vs Indolent 2012

PI: Hollingsworth, Michael

Study Overview. We will examine DNA extracted from FFPE sections from approximately 200 different surgically resected primary pancreatic tumors from the UNMC ...

Hollingsworth - Aggressive vs Indolent 2012 (357)

PI: Hollingsworth, Michael

Study Overview. We will examine DNA extracted from FFPE sections from approximately 200 different surgically resected primary pancreatic tumors from the UNMC ...

Hollingsworth - Aggressive vs Indolent 2012 (359)

PI: Hollingsworth, Michael

LIver Reference Set Applicant (Rapid) Beretta-FHCRC (2011)

PI: Beretta, Laura

LIver Reference Set Applicant (Rapid) Qu-Quest (2011)

PI: Qu, Kevin

LIver Reference Set Applicant (Rapid) Yamada - Wako (2011)

PI: Yamada, Hiro

Measure clinical effectiveness of AFP-L3 and DCP for early detection of HCC in patient samples collected prospectively during surveillance. However since such ...

Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia

PI: Lynch, Henry

Liver Cancer Specimen Reference Set Application (Rapid): Giannelli - Univ of Bari (2008)

PI: Giannelli, Gianluigi

To evaluate biomarker performance in an out-side cohort of LC and HCC patients

Liver Reference Set (Rapid) Norman (2012)

PI: Pepe, Margaret Sullivan

Liver Reference Set Applicant (Full): Lubman - Univ of Michigan (2011)

PI: Lubman, David

Liver Reference Set Applicant (Full): Yamada - Wako (2011)

PI: Yamada, Hiro

Liver Reference Set Applicant (Rapid #1): Lubman - Univ of Michigan (2009)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Reference Set Applicant (Rapid #2) Beretta-FHCRC (2011)

PI: Beretta, Laura

Liver Reference Set Applicant (Rapid #2): Lubman - Univ of Michigan (2010)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Reference Set Application (Full): Block - Drexel Univ (2010)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Reference Set Application (Rapid): Block - Drexel Univ (2008)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

MMR protein expression in HNPCC

PI: Lynch, Henry

Methylation tumor markers in HNPCC

PI: Lynch, Henry

Molecular Basis of Barrett's -Associated Carcinogenesis

PI: Stass, Sanford

Mutational load distribution analysis (MLDA) in pancreatic cancer

PI: Lynch, Henry

Certain p16 mutation carriers showed mutation elevations in the specific Ki-ras and p53 alleles significantly higher than normal, similar to controls with ...

Novel Surveillance Strategies For Hereditary Nonpolyposis Colon Cancer Family Members

PI: Lynch, Henry

Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside)

PI: Lokshin, Anna

Pancreatic Cystic Fluid Reference Set

PI: Brand, Randall E.

Pancreatic Reference Set Applicant-Haab (2012)

PI: Haab, Brian

This study will address the clinical problems of early detection and diagnosis. The samples were obtained from patients with early-stage pancreatic cancer, ...

Pancreatic Reference Set Applicant-Killary (2012)

PI: Killary, Ann M.

Polyp Prediction Study

PI: Meltzer, Stephen

Preliminary Clinical Characterization of Serum Biomarkers for Colorectal Neoplasms

PI: Brenner, Dean

Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)

PI: Brenner, Dean

1   AIMS We propose a GI Collaborative biomarker validation project with the goal of identifying those biomarkers developed by the GI collaborative that will ...

Prognostic Markers in Lynch Syndrome Colorectal Cancers

PI: Lynch, Henry

Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers

PI: Semmes, John

Screen Detection of Mismatch Repair Deficient Colorectal Neoplasias Using a Stool Based DNA Analysis

PI: Lynch, Henry

Spectral Markers for Early Detection of Colon Neoplasia

PI: Roy, Hemant K.

Standard Specimen Reference Set: Liver

PI: Volk, Michael L.

Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC

Standard Specimen Reference Set: Pancreatic

PI: Brand, Randall E.

The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens ...

Standard Specimen Reference Set: Colon

PI: Brenner, Dean

The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, ...

Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis

PI: Markowitz, Sanford

Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict ...

Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010)

PI: Brenner, Dean

We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ...

Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma

PI: Volk, Michael L.

Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early ...

William Grady

PI: Grady, William

OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ...

Data
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Documents
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