Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Collaborative Groups / Breast and Gynecologic Cancers Research Group
Overview

If you are a member of this group, log in to gain full access.

Upcoming Events

Events coming up for the Breast and Gynecologic Cancers Research Group.

No upcoming events.

Biomarkers

There are currently no biomarkers defined for this collaborative group.

Projects/Protocols

Projects

Benign Breast Disease/DCIS Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ...

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Protocols

Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer

PI: Cramer, Daniel

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

BRSCW Applicant: Buechler - Biosite Inc (2009)

PI: Buechler, Joe

Over 40 marker assays are available to run on the samples. These include markers such as Osteopontin, Mesothelin, Periostin, Endoglin, intestinal Fatty Acid ...

BRSCW Applicant: Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Examine kallikreins as ovarian cancer biomarkers and determine sensitivity and specificity of panel

BRSCW Applicant: Abbott 2014

PI: Abbott, Karen

Our earlier glycoproteomic studies have identified bisecting glycoslyation and core fucosylation changes on particular glycoproteins in endometrioid ovarian ...

BRSCW Applicant: Birrer Massachusetts General Hospital 2013

PI: Birrer, Michael

BRSCW Applicant: Morre - NOX Technologies Inc. (2009)

PI: Morre, D. James

Evaluation using NOX Technologies ECTO-NOX blot diagnostic 2-D gel electrophoretic cancer detection system in combination with a sandwich ELISA of our ...

BRSCW Applicant: Tuszynski - Temple University (2012)

PI: Feng, Ziding

BRSCW Applicant: Wilson - EIC Laboratories, Inc (2007)

PI: Wilson, Michael S.

Samples were returned unused. Analysis never completed.

BRSCW Application: Lokshin - Univ of Pitts (2008)

PI: Lokshin, Anna

One KLK,(KLK6) ranked 6th among all tested biomarkers(approx.50)

BRSCW Application: Mathew - Meso Scale (2006)

PI: Mathew, Anu

BRSCW Ref Set Application: Anna Lokshin - Univ of Pitts (2008)

PI: Lokshin, Anna

Validate biomarkers identified using Luminex bead-based arrays in case/control sets (individual samples) in reference sets

BRSCW Reference Set Application: Anu Mathew - Meso Scale (2006)

PI: Mathew, Anu

BRSCW Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Examine kallikreins as ovarian cancer biomarkers

BRSCW Reference Set Application: GeorgeTuszynski - Temple University (2012)

PI: Feng, Ziding

BRSCW Reference Set Application: James Morre - NOX Technologies Inc. (2009)

PI: Morre, D. James

Evaluation using NOX Technologies ECTO-NOX blot diagnostic 2-D gel electrophoretic cancer detection system in combination with a sandwich ELISA of our ...

BRSCW Reference Set Application: Joe Buechler - Biosite Inc (2009)

PI: Buechler, Joe

Over 40 marker assays are available to run on the samples. These include markers such as Osteopontin, Mesothelin, Periostin, Endoglin, intestinal Fatty Acid ...

BRSCW Reference Set Application: Karen Abbott -University of Arkansas (2014)

PI: Abbott, Karen

Our earlier glycoproteomic studies have identified bisecting glycoslyation and core fucosylation changes on particular glycoproteins in endometrioid ovarian ...

BRSCW Reference Set Application: Michael Birrer-Massachusetts General Hospital (2013)

PI: Birrer, Michael

Analysis of this set will not occur at this time. If at a later date, the Investigator's decide to analyze the set, the DMCC will conduct the statistical ...

BRSCWRef Set Application: Michael Wilson - EIC Laboratories, Inc (2007)

PI: Wilson, Michael S.

Samples were returned unused. Analysis never completed.

Benign Breast Disease Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Benign Breast Disease/DCIS Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays: EDRN Supplement

PI: Anderson, Karen

The overall goal of this project application for the EDRN set-aside funds is to focus our collaborative efforts to identify p53 mutation-specific antibody ...

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Reference Sets for Cancers in Women

PI: Cramer, Daniel

The purpose of this study is to develop a standard reference set of specimens for use by investigators participating in the National Cancer Institutes Early ...

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancer

PI: Li, Christopher

Distinguishing aggressive cancers from non-aggressive or non-progressing cancers is an issue of both clinical and public health importance particularly for ...

Body Fluids as a Source of Diagnostic Biomarkers: Breast

PI: Semmes, John

Breast Cancer: subgroups specific blood-biomarkers for early / predictive diagnosis and personalized treatment

PI: Golubnitschaja, Prof. Dr. Olga

Breast-conserving lumpectomy followed by radiation therapy has been shown to be an alternative strategy, competitive to mastectomy, in preventing mortality ...

Breast Ductal Lavage Fluid Specimen Bank

PI: Trock, Bruce

Breast Ref Applicant: Abbott-Arkansas Medical Sciences (2013)

PI: Abbott, Karen

We are evaluating whether detection of a tumor-specific N-linked glycosylation known as B 1,6 branched N-glycan present on the glycoprotein periostin in breast ...

Breast Ref Applicant: Anderson-Arizona (2014)

PI: Anderson, Karen

The aims of the proposal are to evaluate this panel of 28 AAb biomarkers using the EDRN reference set. We propose to use RAPID ELISA containing each of these ...

Breast Ref Applicant: Chris Li (2014)

PI: Li, Christopher

Breast Ref Applicant: Chris Li-FHCRC (2014)

PI: Li, Christopher

Breast Ref Set Applicant: Anu Mathew-Meso Scale (2012)

PI: Mathew, Anu

Breast Reference Set Applicant: Tuszynski-Temple (2012)

PI: Feng, Ziding

Breast Reference Set Applicant: Zangar-PNNL (2012)

PI: Feng, Ziding

Breast Reference Set Applicant:- Zangar-Pacific NW Nat'l Laboratory (2012)

PI: Feng, Ziding

Breast Reference Set Application: Anu Mathew-Meso Scale (2012)

PI: Mathew, Anu

Using a subset of plasma samples (n=505) from the reference set, we analyzed 90 proteins by multiplexed immunoassays for their potential utility as diagnostic ...

Breast Reference Set Application: Chris Li-FHCRC (2014)

PI: Li, Christopher

This application proposes to use Reference Set #1. We request access to serum samples collected at the time of breast biopsy from subjects with IC (n=30) or ...

Breast Reference Set Application: GeorgeTuszynski-Temple (2012)

PI: Feng, Ziding

Breast Reference Set Application: Karen Abbott- University of Arkansas (2013)

PI: Abbott, Karen

We are evaluating whether detection of a tumor-specific N-linked glycosylation known as B 1,6 branched N-glycan present on the glycoprotein periostin in breast ...

Breast Reference Set Application: Karen Anderson-ASU (2014)

PI: Anderson, Karen

In order to increase the predictive value of tumor-specific antibodies for use as immunodiagnostics, our EDRN BDL has developed a novel protein microarray ...

Breast Reference Set Application: Richard Zangar-PNNL (2012)

PI: Feng, Ziding

Our immediate goal is to define a set of biomarkers (composed of circulating plasma proteins) that can be used to distinguish between true and false screens, ...

Breast tissue array

PI: Chia, David

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Clinical Validation of Molecular Signatures of Cervical Neoplasia

PI: Unger, Elizabeth R.

DCIS Team Project

PI: Li, Christopher

Both overtreatment and undertreatment of DCIS are pervasive problems given that no useful approaches for identifying which DCIS patients are likely or highly ...

Detecting Breast Cancer Signatures in Body Fluids

PI: Trock, Bruce

Detecting breast cancer protein signatures in body fluid

PI: Semmes, John

Detection of Serum Markers of Breast Cancer by SELDI

PI: Marks, Jeffrey

Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study

PI: Esserman, Laura J.

Development of FISH-based assay for early detection of high grade cervical dysplasia

PI: Unger, Elizabeth R.

Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets

PI: Esserman, Laura J.

EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project

PI: Li, Christopher

There is an urgent need for breast cancer early detection biomarkers given that none are currently available and given the considerable public health ...

EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial

PI: Li, Christopher

Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ...

EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples

PI: Li, Christopher

We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ...

EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples

PI: Li, Christopher

The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ...

EDRN Longitudinal Serum Biorepository

PI: Lynch, Henry

Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ...

Early Detection Research Network Registry for Hereditary Cancer

PI: Lynch, Henry

The EDRN High Risk Registry (HRR)recruits individuals that carry germline mutations for hereditary cancer syndromes, who are willing to participate in ...

Early Detection of Breast Cancer Using Autoantibody Markers

PI: Tainsky, Michael A.

To identify large numbers of antigens that can be used to recognize the presence of cancer by detecting antibodies to tumor proteins in the serum of the test ...

Establishment of a serum standard for use in high-throughput proteomic

PI: Semmes, John

Expression based markers for breast cancer detection

PI: Marks, Jeffrey

High-Throughput Evaluation of Breast Cancer Markers

PI: Zangar, Richard (Rick) C.

The objective of this study is to use a combination of AMT proteomics and ELISA microarray testing to discover and validate novel biomarkers for breast cancer.

Identification of New Markers in Normal and Abnormal Pap Smears

PI: Unger, Elizabeth R.

National Ovarian Cancer Early Detection Program Blood and Genetics

PI: Fishman, David

Ovarian Cancer Screening Pilot Trial In High Risk Women

PI: Lynch, Henry

BACKGROUND: No proven ovarian cancer (OC) screening strategy exists for women who are at increased risk for the disease. A risk of ovarian cancer algorithm ...

PLCO Ovarian Phase III Validation Study

PI: Cramer, Daniel

The obvious appeal of a strategy for the early detection of ovarian cancer is based upon the tendency for the disease to present at advanced stages associated ...

PTM Microarray: Request for Year 3 Set-Aside Funds

PI: Zangar, Richard (Rick) C.

We hypothesize that PTMs on proteins that are secreted by the breast will provide a more sensitive method for detecting breast cancer than analysis of the ...

Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer

PI: Mor, Gil

While all cancer patients could potentially benefit from earlier detection and prevention, the development of new screening technologies and chemoprevention ...

Protein profiling for detection of high risk breast cancer

PI: Semmes, John

Proteomic Data Resources for EDRN Ovary Cancer Researchers within the EDRN

PI: McIntosh, Martin

This project will generate a highly valuable data resource and make it available to all EDRN ovarian cancer researchers. The resource will include ...

Proteomic Genetic and Longitudinal Pathways to Ovarian Cancer Biomarkers

PI: Skates, Steven

Discovery and verification of early detection ovarian cancer plasma/serum biomarkers.

SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas

PI: Semmes, John

SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

PI: Cramer, Daniel

Phase II specimens from 160 ovarian cancer cases and 640 benign disease or general population controls were assembled from four Early Detection Research ...

Standard Specimen Reference Set: Breast

PI: Marks, Jeffrey

The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ...

Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates

PI: Li, Christopher

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ...

Validation of Autoantibodies as Biomarkers of Breast Cancer

PI: Anderson, Karen

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Year 2 Collaborative Project - UCSF and Battelle PNWD

PI: Zangar, Richard (Rick) C.

To evaluate the effects of receptor status on circulating biomarker levels.

pre-operative plevic mass study

PI: Cramer, Daniel

Data
Calendar

There are no current events.

Past Events

There are no past events.

Documents
 Title   Author   Type   Modified 
Clarifying the Risk of Breast Cancer in Women with Atypical Breast Lesions Heather Kincaid Folder Jan 05, 2012 04:31 PM
File OC Team Project January 2013 Teleconference Minutes Christos Patriotis File Jan 31, 2013 10:30 AM