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Biomarkers
VEGFC
From NCBI Gene: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The ...
SPON2
SPON2, also known as spondin-2, is a cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. It binds directly to ...
Cramer 5-marker panel for ovarian cancer
The PLCO phase III specimens (test half) revealed marker panels produced only marginal improvement over CA 125 alone and, in some case, worse performance. ...
TNFRSF11B
From NCBI Gene: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that ...
CSF1
From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and ...
IGF2
IGF2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. The IGF2 gene is an imprinted gene and is ...
FABP5
From NCBI Gene: This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. ...
TEK
From NCBI Gene: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular ...
CRYAB
From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and ...
SLAMF8
SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in ...
SOST
From NCBI Gene: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential ...
GCLM
From NCBI Gene: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The ...
SFN
From UniProtKB/Swiss-Prot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to ...
BDNF
BDNF (brain-derived neurotrophic factor) is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of ...
FLT1
From NCBI Gene: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine ...
S100A6
From NCBI Gene: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are ...
FIGF
From NCBI Gene: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is ...
TSHB
TSH, a secreted protein belonging to the glycoprotein hormones subunit beta family, is essential for the control of thyroid structure and metabolism. The four ...
PSAT1
From NCBI Gene: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine ...
MMP10
From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, ...
EIF3E
From UniProtKB/Swiss-Prot: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation ...
MMP3
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as ...
SELL
From NCBI Gene and UniProtKB/Swiss-Prot: sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing ...
CCL2
From NCBI Gene: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved ...
MYOZ2
From NCBI Gene: The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in ...
RAB5A
From UniProtKB/Swiss-Prot: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their ...
ST14
ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this ...
SEC23B
SEC23B is a member of the SEC23B/SEC24B family. SEC23B is a component of the COPII coat, that covers ER-derived vesicles involved in transport from the ...
TNFAIP1
The expression of this gene can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Mouse studies suggest the expression ...
PPP2R4
From NCBI Gene: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. ...
TNFAIP6
TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly ...
PRDX4
From NCBI Gene: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. ...
CXCL8
CXCL8, formerly known as IL8, is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that attracts ...
SERPINH1
From NCBI Gene: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic ...
SCGB2A1
SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is ...
SLC30A6
SLC30A6 is a zinc-efflux transporter which has been shown by similarity to be involved in distributing the cytoplasmic zinc to the trans-Golgi network (TGN) as ...
IL6
Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In ...
RAC1
From NCBI Gene: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily ...
CCL5
From NCBI Gene: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins ...
MPO
Myeloperoxidase (MPO) is a lysosomal heme protein found at chromosomal location 17q23.1. It is produced as a single chain precursor that is cleaved into two ...
PIGF
From NCBI Gene: This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three ...
CCL11
From NCBI Gene: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted ...
SAA@
SAA@, or serum amyloid A1 cluster, is a gene cluster.
MMP2
MMP2 is a member of the matrix metalloproteinase (MMP) family and is involved in many functions, such as remodeling of the vasculature, angiogenesis, tissue ...
SAT1
From NCBI Gene: The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine ...
PRL
There is increasing evidence that prolactin (PRL), a hormone/cytokine, plays a role in breast, prostate, and colorectal cancers via local production or ...
SATL1
SATL1 is a protein coding gene that has been found to be conserved across Rhesus monkey, dog, cow, mouse, rat, and frog. SATL1 shows N-acetyltransferase ...
GDF15
GDF15, also known as macrophage inhibitory cytokine 1, or MIC1, is a bone morphogenetic protein (BMP) belonging to the transforming growth factor-beta ...
CCDC102B
CCDC102B, or coiled-coil domain-containing protein 102B, has two isoforms produced by alternative splicing.
SOX2
From NCBI Gene: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic ...
S100A4
From NCBI Gene: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are ...
FAM83H
FAM83H is a member of the FAM83 family and plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a ...
VTCN1
Highly glycosylated sialomucin; expressed on immune cells. Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, ...
KLK8
KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin ...
MMP9
MMP9 is a member of the matrix metalloproteinase (MMP) family. It is a secreted protein that may play an essential role in local proteolysis of the ...
FJX1
FJX1 is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and ...
IL10
From NCBI Gene: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has ...
GPM6B
GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is ...
CRIP2
Cysteine-rich intestinal protein 2 (CRIP2) has been shown to be involved in development. It is expressed in a variety of tissues, with particularly high ...
P2RY14
P2RY14, or GPR105, is a G-protein coupled receptor that responds to extracellular purine and pyrimidine nucleotides. P2RY14 is not activated by ATP, ADP, ...
TNFRSF1B
TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the ...
FNDC3A
Fndc3a is a member of a three-gene family in mice. Mouse Fndc3a is composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a ...
FZD10
FZD10 is a member of the frizzled gene family. The frizzled gene family encodes 7-transmembrane domain proteins that are receptors for the Wingless type MMTV ...
RMND5A
RMND5A (FLJ13910) is also known as required for meiotic nuclear division 5 homolog A (S. cerevisiae). There are two isoforms of this human protein, ...
CA125
MUC16 (CA125) is a highly glycosylated sialomucin that is expressed on epithelial cell surface, especially on ovarian cancer cells. MUC16 is anchored to the ...
IGFBP1
IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a ...
ERBB2
From NCBI Gene: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand ...
TFCP2
From NCBI Gene: This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded ...
ODC1
From NCBI Gene: This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level ...
ZNF510
ZNF510 is a zinc finger protein thought to be involved in transcriptional regulation.
NME2
From NCBI Gene: Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) ...
CA72-4
High-MW mucin-type glycoprotein expressed on epithelial cancer cells.
MBD1
From NCBI Gene: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). ...
CCL22
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of ...
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker ...
MAPK14
From NCBI Gene: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical ...
CCL26
From NCBI Gene: This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins ...
GPR65
GPR65, a member of the G-protein coupled receptor 1 family, is a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. ...
MMP1
From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, ...
CCL4
From NCBI Gene: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The ...
MET
From NCBI Gene: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain ...
WFDC2
11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of ...
CDH3
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein ...
PSA
KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily ...
BGLAP
BGLAP, also known as osteocalcin, makes up 1-2% of the total bone protein. It also binds strongly to apatite and calcium.
GPANK1
GPANK1, also known as BAT4, is part of a cluster of genes, BAT1-BAT5. These genes are HLA-B associated transcripts, and are included in the human major ...
KDR
From NCBI Gene: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the ...
CCL13
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of ...
SPP1
Osteopontin, also known as SPP1 or OPN, a secreted, integrin-binding matrix phosphorylated glycoprotein is involved in bone remodeling by osteoclasts and ...
ICAM1
From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to ...
MAGEA4
From NCBI Gene: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The ...
CCL17
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of ...
ATF3
ATF3 is a member of the the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. The ATF3 ...
FOLH1B
FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related ...
LBP
From NCBI Gene: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative ...
CHGA
From NCBI Gene: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in ...
FSH
Follicle stimulating hormone, a heterodimer glycoprotein of a common alpha chain and a unique beta chain which confers biological specificity to ...
TIMP1
The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in ...
C15orf48
C15orf48 is expressed mainly in adult stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. The gene was first identified in ...
PCDH17
PCDH17 is a member of the protocadherin gene family, a subfamily of the cadherin superfamily. PCDH17 has six extracellular cadherin domains, a transmembrane ...
GPR157
GPR157 is a multi-pass transmembrane G protein-coupled receptor protein. GPR157 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and ...
CRP
From NCBI Gene: The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability ...
CA15-3
From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role ...
AFP
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with ...
WWC1
WWC1, or KIBRA, is a cytoplasmic phosphoprotein. Expression has been detected in the brain, heart, colon and kidney, as well as mammary epithelial cells ...
UBAP1
From NCBI Gene: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. ...
EFR3A
EFR3A (KIAA0143) is a membrane protein. Little is known about its function, although studies on the mouse homolog have suggested a role in hearing. It has ...
MMP7
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as ...
FGF2
From NCBI Gene: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad ...
HOXA9
HOXA9 is a sequence-specific transcription factor. It is a member of the homeobox gene family. These transcription factors are spatially and temporally ...
MSLN
Mesothelin, a cell surface antigen, was isolated using an antibody that reacts with ovarian cancers and mesotheliomas. Although the function of mesothelin is ...
VCAM1
VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, is a cell surface sialoglycoprotein expressed by cytokine-activated ...
OLFML2B
OLFML2B is a secreted protein. The gene is conserved across many species. The protein is a homodimer.
SLC11A1
SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain ...
MIF
MIF, a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation, plays a role in the regulation of macrophage function in host defense ...
LGALS3BP
LGALS3BP is a secreted protein that binds to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. Elevated levels of LGALS3BP have ...
SLPI
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical ...
LEP
Leptin (LEP) is secreted by white adipocytes and plays a major role in the regulation of body weight. This protein, which acts through the leptin ...
IGFBP2
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell ...
PVRL4
The PVRL4 protein, also known as nectin-4, is a member of the nectin family. PVRL4 contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like ...
DEFB1
DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the ...
GH1
Growth hormone, a secreted protein which exists as a monomer, dimer, trimer, tetramer and pentamer and is disulfide-linked or non-covalently associated in ...
VTA1
VTA1 (C6ORF55) is involved in activities of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in ...
ANXA1
Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. ...
MPPED2
MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). ...
BMX
BMX, or BMX non-receptor tyrosine kinase, belongs to the Tec kinase family. BMX, a non-receptor tyrosine kinase, plays a central but diverse modulatory role in ...
ACKR3
ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not ...
RAC3
From NCBI Gene: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily ...
CDCP1
CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is ...
HOXD1
From NCBI Gene: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a ...
EPB41L3
EPB41L3 protein is a critical growth regulator in the pathogenesis of meningiomas. There are three isoforms of this protein, produced by alternative splicing.
CSNK1E
CSNK1E is a serine/threonine protein kinase and a member of the casein kinase I protein family. Casein kinases are characterized by their preferential ...
EGFL6
EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the ...
FRS3
From NCBI Gene: This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and ...
MPZL2
The EVA1, or MPZL2 gene is expressed in the thymus and in several epithelial structures early in embryogenesis. The protein MPZL2 displays an ability to ...
PDCD6IP
From NCBI Gene: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle ...
EPSTI1
EPSTI1 is highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. There are three isoforms of this protein, ...
ZMYM6
ZMYM6 is an MYM zinc finger protein. Zinc fingers are DNA binding proteins located in the cell nucleus.
DBT
From NCBI Gene: The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the ...
SERPINB3
Squamous cell carcinoma antigen (SCCA) may act as a protease inhibitor to modulate the host immune response against tumor cells. Present in the cytoplasm of ...
IL4
From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. ...
SLC33A1
From NCBI Gene: The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 ...
ATP6AP1
ATP6AP1 is an integral membrane protein composed of at least 10 subunits. It is responsible for acidifying various eukaryotic intracellular organelles. ...
IL5
From NCBI Gene: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a ...
TRIM32
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, ...
SF3A1
From NCBI Gene: This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 ...
GSTM2
From NCBI Gene: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct ...
IL1B
From NCBI Gene: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a ...
LHB
The pituitary glycoprotein hormone family includes follicle stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG), and ...
ALG10
ALG10 is a membrane associated protein found in the endoplasmic reticulum. It is responsible for adding the third glucose residue to the lipid-linked ...
CTBP1
From NCBI Gene: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may ...
IL2
From NCBI Gene: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this ...
APOA1
APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for ...
IL2RA
The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of ...
IL13
From NCBI Gene: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell ...
IL18
From NCBI Gene: The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates ...
IL6R
The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal ...
CEACAM5
From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the ...
CXCL10
From NCBI Gene: This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in ...
HGF
From NCBI Gene: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after ...
TNF
TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and ...
IFNG
From NCBI Gene: This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and ...
SDC1
SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The SDC1 protein functions as an integral ...
GSTM1
From NCBI Gene: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct ...
AKR1C2
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes ...
KRT19
KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. ...
TNFRSF1A
TNFRSF1A, one of the major receptors for the TNF-alpha, is a member of the TNF-receptor superfamily. This protein activates NF-kappaB, mediates apoptosis, and ...
IL12
The cytokine IL12, also known as IL12-p70, is the heterodimer formed by the protein products of the IL12A and IL12B genes. IL12A has a molecular weight ...
ADAM12
ADAM12 is a member of the ADAM (a disintegrin and metalloprotease) protein family. ADAM family members are membrane-anchored proteins structurally related to ...
PPBP
CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant ...
KLK6
Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control ...
ROMA
The Risk of Ovarian Malignancy Algorithm (ROMA) algorithm was approved by the FDA in 2011. Research demonstrates that examining levels of HE4 and CA125 ...
B2M
B2M, a secreted protein belonging to the beta-2-microglobulin family, is a component of the class I major histocompatibility complex (MHC) on the surface of ...
ACTR3
The ACTR3 protein is a component of the ARP2/3 complex, which is essential to cell shape and motility.
AKR1B1
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member ...
EGFR
From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor ...
CDH1
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein ...
ADIPOQ
From NCBI Gene: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. ...
ALPL
From NCBI Gene: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue ...
LZTS1
LZTS1 is a tumor suppressor protein that is widely expressed in normal tissues. It is involved in regulating cell growth and is also thought to interact with ...
GPI
From NCBI Gene: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein ...
BCL2L2
From NCBI Gene: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and ...
GLO1
From NCBI Gene: The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and ...
Projects/Protocols

Projects

There are currently no projects of which this group is a part.

Protocols

Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer

PI: Cramer, Daniel

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

BBD Reference Set Application: Jeffery Marks-Duke (2015)

PI: Marks, Jeffrey

We propose a pre-validation study for markers that could predict the likelihood of invasive breast cancer following a tissue diagnosis of benign breast ...

BRSCW Reference Set Application: Anna Lokshin - Univ of Pitts (2008)

PI: Lokshin, Anna

Validate biomarkers identified using Luminex bead-based arrays in case/control sets (individual samples) in reference sets

BRSCW Reference Set Application: Anu Mathew - Meso Scale (2006)

PI: Mathew, Anu

46 markers were tested on pooled case samples and on control samples.

BRSCW Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Examine kallikreins as ovarian cancer biomarkers

BRSCW Reference Set Application: GeorgeTuszynski - Temple University (2012)

PI: Tuszynski, George

The marker GASP-1 was evaluated in the pooled breast cancer reference set. It did not seem to be elevated relative to controls.

BRSCW Reference Set Application: James Morre - NOX Technologies Inc. (2009)

PI: Morre, D. James

Evaluation using NOX Technologies ECTO-NOX blot diagnostic 2-D gel electrophoretic cancer detection system in combination with a sandwich ELISA of our ...

BRSCW Reference Set Application: Joe Buechler - Biosite Inc (2009)

PI: Buechler, Joe

Over 40 marker assays are available to run on the samples. These include markers such as Osteopontin, Mesothelin, Periostin, Endoglin, intestinal Fatty Acid ...

BRSCW Reference Set Application: Karen Abbott -University of Arkansas (2014)

PI: Abbott, Karen

Our earlier glycoproteomic studies have identified bisecting glycoslyation and core fucosylation changes on particular glycoproteins in endometrioid ovarian ...

BRSCW Reference Set Application: Michael Birrer-Massachusetts General Hospital (2013)

PI: Birrer, Michael

Validate FGF18 and GPR172A in reference set

BRSCW Reference Set Application: Michael Wilson - EIC Laboratories, Inc (2007)

PI: Wilson, Michael S.

The selected markers are well established as "standard" markers fo ra range of cancers, and have been analyzed in the reference set as a benchmark for ...

Benign Breast Disease Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays

PI: LaBaer, Joshua

Cancer patients spontaneously generate autoantibodies (AAb) to tumor-derived proteins. To detect AAb, we have probed novel high-density custom protein ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays: EDRN Supplement

PI: Anderson, Karen

The overall goal of this project application for the EDRN set-aside funds is to focus our collaborative efforts to identify p53 mutation-specific antibody ...

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Reference Sets for Cancers in Women

PI: Cramer, Daniel

The purpose of this study is to develop a standard reference set of specimens for use by investigators participating in the National Cancer Institutes Early ...

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancer

PI: Li, Christopher

Distinguishing aggressive cancers from non-aggressive or non-progressing cancers is an issue of both clinical and public health importance particularly for ...

Body Fluids as a Source of Diagnostic Biomarkers: Breast

PI: Semmes, John

Breast Cancer: subgroups specific blood-biomarkers for early / predictive diagnosis and personalized treatment

PI: Golubnitschaja, Prof. Dr. Olga

Breast-conserving lumpectomy followed by radiation therapy has been shown to be an alternative strategy, competitive to mastectomy, in preventing mortality ...

Breast Ductal Lavage Fluid Specimen Bank

PI: Trock, Bruce

Breast Reference Set Application: Anu Mathew-Meso Scale (2012)

PI: Mathew, Anu

Using a subset of plasma samples (n=505) from the reference set, we analyzed 90 proteins by multiplexed immunoassays for their potential utility as diagnostic ...

Breast Reference Set Application: Chris Li-FHCRC (2014)

PI: Li, Christopher

This application proposes to use Reference Set #1. We request access to serum samples collected at the time of breast biopsy from subjects with IC (n=30) or ...

Breast Reference Set Application: Chris Li-FHCRC (2015)

PI: Li, Christopher

Breast Reference Set Application: GeorgeTuszynski-Temple (2012)

PI: Tuszynski, George

As recommended by the review committee, we will analyze 30 invasive cancer cases and 30 benign controls from the EDRN breast reference set. Cases and controls ...

Breast Reference Set Application: Karen Abbott- University of Arkansas (2013)

PI: Abbott, Karen

We are evaluating whether detection of a tumor-specific N-linked glycosylation known as B 1,6 branched N-glycan present on the glycoprotein periostin in breast ...

Breast Reference Set Application: Karen Anderson-ASU (2014)

PI: Anderson, Karen

In order to increase the predictive value of tumor-specific antibodies for use as immunodiagnostics, our EDRN BDL has developed a novel protein microarray ...

Breast Reference Set Application: Pinku Mukherjee-CanDiag (2014)

PI: Mukherjee, Pinku

We would like to get all three sets of specimens, however, we are requesting Specimen Set 1 first: 30 subjects with invasive cancer and 30 subjects with benign ...

Breast Reference Set Application: Richard Zangar-PNNL (2012)

PI: Zangar, Richard (Rick) C.

Our immediate goal is to define a set of biomarkers (composed of circulating plasma proteins) that can be used to distinguish between true and false screens, ...

Breast tissue array

PI: Chia, David

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Clinical Validation of Molecular Signatures of Cervical Neoplasia

PI: Unger, Elizabeth R.

DCIS Team Project

PI: Li, Christopher

Both overtreatment and undertreatment of DCIS are pervasive problems given that no useful approaches for identifying which DCIS patients are likely or highly ...

Detecting Breast Cancer Signatures in Body Fluids

PI: Trock, Bruce

Detecting breast cancer protein signatures in body fluid

PI: Semmes, John

Detection of Serum Markers of Breast Cancer by SELDI

PI: Marks, Jeffrey

Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study

PI: Esserman, Laura J.

Development of FISH-based assay for early detection of high grade cervical dysplasia

PI: Unger, Elizabeth R.

Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets

PI: Esserman, Laura J.

EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project

PI: Li, Christopher

To identify promising candidate plasma early detection biomarkers specific to different molecular subtypes of breast cancer using preclinical specimens from ...

EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial

PI: Li, Christopher

Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ...

EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples

PI: Li, Christopher

We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ...

EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples

PI: Li, Christopher

The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ...

EDRN Longitudinal Serum Biorepository

PI: Lynch, Henry

Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ...

Early Detection Research Network Registry for Hereditary Cancer

PI: Lynch, Henry

The EDRN High Risk Registry (HRR)recruits individuals that carry germline mutations for hereditary cancer syndromes, who are willing to participate in ...

Early Detection of Breast Cancer Using Autoantibody Markers

PI: Tainsky, Michael A.

To identify large numbers of antigens that can be used to recognize the presence of cancer by detecting antibodies to tumor proteins in the serum of the test ...

Establishment of a serum standard for use in high-throughput proteomic

PI: Semmes, John

Expression based markers for breast cancer detection

PI: Marks, Jeffrey

High-Throughput Evaluation of Breast Cancer Markers

PI: Zangar, Richard (Rick) C.

The objective of this study is to use a combination of AMT proteomics and ELISA microarray testing to discover and validate novel biomarkers for breast cancer.

Identification of New Markers in Normal and Abnormal Pap Smears

PI: Unger, Elizabeth R.

Intergrated Systems Biology Approach for Ovarian Cancer Biomarker Discovery

PI: Diamandis, Eleftherios P.

The overall objective is to validate serum protein markers for early diagnosis of ovarian cancer with the ultimate goal being to develop a multiparametric ...

National Ovarian Cancer Early Detection Program Blood and Genetics

PI: Fishman, David

Ovarian Cancer Screening Pilot Trial In High Risk Women

PI: Lynch, Henry

BACKGROUND: No proven ovarian cancer (OC) screening strategy exists for women who are at increased risk for the disease. A risk of ovarian cancer algorithm ...

PLCO Ovarian Phase III Validation Study

PI: Cramer, Daniel

Our preliminary data indicate that the performance of CA 125 as a screening test for ovarian cancer can be improved upon by additional biomarkers. With ...

PTM Microarray: Request for Year 3 Set-Aside Funds

PI: Zangar, Richard (Rick) C.

We hypothesize that PTMs on proteins that are secreted by the breast will provide a more sensitive method for detecting breast cancer than analysis of the ...

Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer

PI: Mor, Gil

While all cancer patients could potentially benefit from earlier detection and prevention, the development of new screening technologies and chemoprevention ...

Pre-operative plevic mass study

PI: Cramer, Daniel

Protein profiling for detection of high risk breast cancer

PI: Semmes, John

Proteomic Data Resources for EDRN Ovary Cancer Researchers within the EDRN

PI: McIntosh, Martin

This project will generate a highly valuable data resource and make it available to all EDRN ovarian cancer researchers. The resource will include ...

Proteomic Genetic and Longitudinal Pathways to Ovarian Cancer Biomarkers

PI: Skates, Steven

Discovery and verification of early detection ovarian cancer plasma/serum biomarkers.

SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas

PI: Semmes, John

SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

PI: Cramer, Daniel

Create a new set of phase II specimens (160 cases with pre-operative bloods representing major histologic types and including 80 early-staged and 80 ...

Standard Specimen Reference Set: Breast

PI: Marks, Jeffrey

The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ...

Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates

PI: Li, Christopher

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ...

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Year 2 Collaborative Project - UCSF and Battelle PNWD

PI: Zangar, Richard (Rick) C.

To evaluate the effects of receptor status on circulating biomarker levels.

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Documents
 Title   Author   Type   Modified 
Clarifying the Risk of Breast Cancer in Women with Atypical Breast Lesions Heather Kincaid Folder Jan 05, 2012 04:31 PM
File OC Team Project January 2013 Teleconference Minutes Christos Patriotis File Jan 31, 2013 10:30 AM
File February 2015 Breast/GYN Collaborative Group Call Minutes Heather Kincaid File Mar 29, 2015 02:03 PM
File Breast/GYN Collaborative Group Call Minutes030415 Heather Kincaid File Apr 06, 2016 05:27 PM
File Breast/GYN Collaborative Group Call Minutes050615 Heather Kincaid File Apr 06, 2016 05:33 PM
File Breast/GYN Collaborative Group Call Minutes060315 Heather Kincaid File Apr 06, 2016 06:03 PM