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Biomarkers
CCL11
Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two ...
IL6R
The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal ...
KRT19
KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. ...
TNF
TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and ...
ADAM12
ADAM12 is a member of the ADAM (a disintegrin and metalloprotease) protein family. ADAM family members are membrane-anchored proteins structurally related to ...
ST14
ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this ...
SLAMF8
SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in ...
ROMA
The Risk of Ovarian Malignancy Algorithm (ROMA) algorithm was approved by the FDA in 2011. Research demonstrates that examining levels of HE4 and CA125 ...
TNFAIP1
The expression of this gene can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Mouse studies suggest the expression ...
ERBB2
ERBB2, often known as HER-2/neu, a single-pass type I membrane protein, is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine ...
ACTR3
The ACTR3 protein is a component of the ARP2/3 complex, which is essential to cell shape and motility.
TNFAIP6
TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly ...
PPBP
CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant ...
FSH
Follicle stimulating hormone, a heterodimer glycoprotein of a common alpha chain and a unique beta chain which confers biological specificity to ...
SCGB2A1
SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is ...
SDC1
SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The SDC1 protein functions as an integral ...
GH1
Growth hormone, a secreted protein which exists as a monomer, dimer, trimer, tetramer and pentamer and is disulfide-linked or non-covalently associated in ...
SEC23B
SEC23B is a member of the SEC23B/SEC24B family. SEC23B is a component of the COPII coat, that covers ER-derived vesicles involved in transport from the ...
B2M
B2M, a secreted protein belonging to the beta-2-microglobulin family, is a component of the class I major histocompatibility complex (MHC) on the surface of ...
SLC30A6
SLC30A6 is a zinc-efflux transporter which has been shown by similarity to be involved in distributing the cytoplasmic zinc to the trans-Golgi network (TGN) as ...
EGFR
EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor ...
PRL
There is increasing evidence that prolactin (PRL), a hormone/cytokine, plays a role in breast, prostate, and colorectal cancers via local production or ...
MIF
MIF, a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation, plays a role in the regulation of macrophage function in host defense ...
CCDC102B
CCDC102B, or coiled-coil domain-containing protein 102B, has two isoforms produced by alternative splicing.
ATF3
ATF3 is a member of the the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. The ATF3 ...
FAM83H
FAM83H is a member of the FAM83 family and plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a ...
FJX1
FJX1 is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and ...
C15orf48
C15orf48 is expressed mainly in adult stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. The gene was first identified in ...
GPM6B
GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is ...
BMX
BMX, or BMX non-receptor tyrosine kinase, belongs to the Tec kinase family. BMX, a non-receptor tyrosine kinase, plays a central but diverse modulatory role in ...
BDNF
BDNF (brain-derived neurotrophic factor) is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of ...
BAT4
GPANK1, also known as BAT4, is part of a cluster of genes, BAT1-BAT5. These genes are HLA-B associated transcripts, and are included in the human major ...
P2RY14
P2RY14, or GPR105, is a G-protein coupled receptor that responds to extracellular purine and pyrimidine nucleotides. P2RY14 is not activated by ATP, ADP, ...
FNDC3A
Fndc3a is a member of a three-gene family in mice. Mouse Fndc3a is composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a ...
IL8
Interleukin 8 (IL8) is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that attracts neutrophils, ...
FZD10
FZD10 is a member of the frizzled gene family. The frizzled gene family encodes 7-transmembrane domain proteins that are receptors for the Wingless type MMTV ...
GPR65
GPR65, a member of the G-protein coupled receptor 1 family, is a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. ...
IL6
Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In ...
MPO
Myeloperoxidase (MPO) is a lysosomal heme protein found at chromosomal location 17q23.1. It is produced as a single chain precursor that is cleaved into two ...
RMND5A
RMND5A (FLJ13910) is also known as required for meiotic nuclear division 5 homolog A (S. cerevisiae). There are two isoforms of this human protein, ...
FOLH1B
FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related ...
MMP2
MMP2 is a member of the matrix metalloproteinase (MMP) family and is involved in many functions, such as remodeling of the vasculature, angiogenesis, tissue ...
WWC1
WWC1, or KIBRA, is a cytoplasmic phosphoprotein. Expression has been detected in the brain, heart, colon and kidney, as well as mammary epithelial cells ...
EFR3A
EFR3A (KIAA0143) is a membrane protein. Little is known about its function, although studies on the mouse homolog have suggested a role in hearing. It has ...
GDF15
GDF15, also known as macrophage inhibitory cytokine 1, or MIC1, is a bone morphogenetic protein (BMP) belonging to the transforming growth factor-beta ...
HOXA9
HOXA9 is a sequence-specific transcription factor. It is a member of the homeobox gene family. These transcription factors are spatially and temporally ...
KLK8
KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin ...
OLFML2B
OLFML2B is a secreted protein. The gene is conserved across many species. The protein is a homodimer.
SLC11A1
SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain ...
IL10
Interleukin 10, a secreted protein belonging to the IL-10 family, is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. It ...
LZTS1
LZTS1 is a tumor suppressor protein that is widely expressed in normal tissues. It is involved in regulating cell growth and is also thought to interact with ...
LGALS3BP
LGALS3BP is a secreted protein that binds to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. Elevated levels of LGALS3BP have ...
TNFRSF1B
TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the ...
TSHB
TSH, a secreted protein belonging to the glycoprotein hormones subunit beta family, is essential for the control of thyroid structure and metabolism. The four ...
IGFBP1
IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a ...
KLK6
Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control ...
VTA1
VTA1 (C6ORF55) is involved in activities of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in ...
CA125
MUC16 (CA125) is a highly glycosylated sialomucin that is expressed on epithelial cell surface, especially on ovarian cancer cells. MUC16 is anchored to the ...
MPPED2
MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). ...
B7-H4
Highly glycosylated sialomucin; expressed on immune cells. Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, ...
ACKR3
ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not ...
CDCP1
CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is ...
CA72-4
High-MW mucin-type glycoprotein expressed on epithelial cancer cells.
CRIP2
Cysteine-rich intestinal protein 2 (CRIP2) has been shown to be involved in development. It is expressed in a variety of tissues, with particularly high ...
DEFB1
DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the ...
CA19-9
CA19-9 may be a molecular marker for ovarian cancer. Literature suggests that the concomitant measurement of CA19-9 with CA125 could offer some benefit in the ...
PCDH17
PCDH17 is a member of the protocadherin gene family, a subfamily of the cadherin superfamily. PCDH17 has six extracellular cadherin domains, a transmembrane ...
EPB41L3
EPB41L3 protein is a critical growth regulator in the pathogenesis of meningiomas. There are three isoforms of this protein, produced by alternative splicing.
EGFL6
EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the ...
HE4
11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of ...
MPZL2
The EVA1, or MPZL2 gene is expressed in the thymus and in several epithelial structures early in embryogenesis. The protein MPZL2 displays an ability to ...
EPSTI1
EPSTI1 is highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. There are three isoforms of this protein, ...
Cramer 5-marker panel for ovarian cancer
The PLCO phase III specimens (test half) revealed marker panels produced only marginal improvement over CA 125 alone and, in some case, worse performance. ...
AFP
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with ...
CA15-3
CA15-3 may be a molecular marker for ovarian cancer. Literature suggests that the concomitant measurement of CA15-3 with CA125 could be advantageous in the ...
IGF2
IGF2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. The IGF2 gene is an imprinted gene and is ...
ALG10
ALG10 is a membrane associated protein found in the endoplasmic reticulum. It is responsible for adding the third glucose residue to the lipid-linked ...
MMP7
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as ...
LEP
Leptin (LEP) is secreted by white adipocytes and plays a major role in the regulation of body weight. This protein, which acts through the leptin ...
MSLN
Mesothelin, a cell surface antigen, was isolated using an antibody that reacts with ovarian cancers and mesotheliomas. Although the function of mesothelin is ...
SLPI
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical ...
IGFBP2
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell ...
CSNK1E
CSNK1E is a serine/threonine protein kinase and a member of the casein kinase I protein family. Casein kinases are characterized by their preferential ...
ATP6AP1
ATP6AP1 is an integral membrane protein composed of at least 10 subunits. It is responsible for acidifying various eukaryotic intracellular organelles. ...
APOA1
APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for ...
LHB
The pituitary glycoprotein hormone family includes follicle stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG), and ...
CEACAM5
CEA is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. It is a receptor for E.coli Dr adhesins.
SPON2
SPON2, also known as spondin-2, is a cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. It binds directly to ...
IL2RA
The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of ...
Projects/Protocols

Projects

Benign Breast Disease/DCIS Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Early diagnosis of triple negative breast cancer would likely have significant impact on overall breast cancer mortality. This proposal is designed to ...

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Protocols

Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer

PI: Cramer, Daniel

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

BRSCW Applicant: Buechler - Biosite Inc (2009)

PI: Buechler, Joe

Over 40 marker assays are available to run on the samples. These include markers such as Osteopontin, Mesothelin, Periostin, Endoglin, intestinal Fatty Acid ...

BRSCW Applicant: Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Examine kallikreins as ovarian cancer biomarkers and determine sensitivity and specificity of panel

BRSCW Applicant: Birrer Massachusetts General Hospital 2013

PI: Birrer, Michael

BRSCW Applicant: Morre - NOX Technologies Inc. (2009)

PI: Morre, D. James

Evaluation using NOX Technologies ECTO-NOX blot diagnostic 2-D gel electrophoretic cancer detection system in combination with a sandwich ELISA of our ...

BRSCW Applicant: Tuszynski - Temple University (2012)

PI: Thornquist, Mark D

BRSCW Applicant: Wilson - EIC Laboratories, Inc (2007)

PI: Wilson, Michael S.

Samples were returned unused. Analysis never completed.

BRSCW Application: Lokshin - Univ of Pitts (2008)

PI: Lokshin, Anna

One KLK,(KLK6) ranked 6th among all tested biomarkers(approx.50)

BRSCW Application: Mathew - Meso Scale (2006)

PI: Mathew, Anu

Benign Breast Disease Team Project

PI: Engstrom, Paul

This procedure applies to identification of the cohort and of cases and controls from the cohort of women with the diagnosis of benign breast conditions, and ...

Benign Breast Disease/DCIS Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays: EDRN Supplement

PI: Anderson, Karen

The overall goal of this project application for the EDRN set-aside funds is to focus our collaborative efforts to identify p53 mutation-specific antibody ...

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Reference Sets for Cancers in Women

PI: Cramer, Daniel

The purpose of this study is to develop a standard reference set of specimens for use by investigators participating in the National Cancer Institutes Early ...

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancer

PI: Li, Christopher

Distinguishing aggressive cancers from non-aggressive or non-progressing cancers is an issue of both clinical and public health importance particularly for ...

Body Fluids as a Source of Diagnostic Biomarkers: Breast

PI: Semmes, John

Breast Cancer: subgroups specific blood-biomarkers for early / predictive diagnosis and personalized treatment

PI: Golubnitschaja, Prof. Dr. Olga

Breast-conserving lumpectomy followed by radiation therapy has been shown to be an alternative strategy, competitive to mastectomy, in preventing mortality ...

Breast Ductal Lavage Fluid Specimen Bank

PI: Trock, Bruce

Breast Ref Applicant: Abbott Arkansas Medical Sciences 2013

PI: Abbott, Karen

Breast Ref Set Applicant: Anu Mathew-Meso Scale 2012

PI: Mathew, Anu

Breast Reference Set Applicant-Tuszynski-Temple (2012)

PI: Thornquist, Mark D

Breast Reference Set Applicant:- Zangar-Pacific NW Nat'l Laboratory (2012)

PI: Thornquist, Mark D

Breast tissue array

PI: Chia, David

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Clinical Validation of Molecular Signatures of Cervical Neoplasia

PI: Unger, Elizabeth R.

DCIS Team Project

PI: Li, Christopher

This procedure applies to identification of the cohort and of cases and controls from the cohort of women with the diagnosis of DCIS at the Seattle CVC (PI= ...

Detecting Breast Cancer Signatures in Body Fluids

PI: Trock, Bruce

Detecting breast cancer protein signatures in body fluid

PI: Semmes, John

Detection of Serum Markers of Breast Cancer by SELDI

PI: Marks, Jeffrey

Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study

PI: Esserman, Laura J.

Development of FISH-based assay for early detection of high grade cervical dysplasia

PI: Unger, Elizabeth R.

Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets

PI: Esserman, Laura J.

EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project

PI: Li, Christopher

There is an urgent need for breast cancer early detection biomarkers given that none are currently available and given the considerable public health ...

EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial

PI: Li, Christopher

Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ...

EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples

PI: Li, Christopher

We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ...

EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples

PI: Li, Christopher

The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ...

EDRN Longitudinal Serum Biorepository

PI: Lynch, Henry

Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ...

Early Detection Research Network Registry for Hereditary Cancer

PI: Lynch, Henry

The EDRN High Risk Registry (HRR)recruits individuals that carry germline mutations for hereditary cancer syndromes, who are willing to participate in ...

Early Detection of Breast Cancer Using Autoantibody Markers

PI: Tainsky, Michael A.

To identify large numbers of antigens that can be used to recognize the presence of cancer by detecting antibodies to tumor proteins in the serum of the test ...

Establishment of a serum standard for use in high-throughput proteomic

PI: Semmes, John

Expression based markers for breast cancer detection

PI: Marks, Jeffrey

High-Throughput Evaluation of Breast Cancer Markers

PI: Zangar, Richard (Rick) C.

The objective of this study is to use a combination of AMT proteomics and ELISA microarray testing to discover and validate novel biomarkers for breast cancer.

Identification of New Markers in Normal and Abnormal Pap Smears

PI: Unger, Elizabeth R.

National Ovarian Cancer Early Detection Program Blood and Genetics

PI: Fishman, David

Ovarian Cancer Screening Pilot Trial In High Risk Women

PI: Lynch, Henry

BACKGROUND: No proven ovarian cancer (OC) screening strategy exists for women who are at increased risk for the disease. A risk of ovarian cancer algorithm ...

PLCO Ovarian Phase III Validation Study

PI: Cramer, Daniel

The obvious appeal of a strategy for the early detection of ovarian cancer is based upon the tendency for the disease to present at advanced stages associated ...

PTM Microarray: Request for Year 3 Set-Aside Funds

PI: Zangar, Richard (Rick) C.

We hypothesize that PTMs on proteins that are secreted by the breast will provide a more sensitive method for detecting breast cancer than analysis of the ...

Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer

PI: Mor, Gil

While all cancer patients could potentially benefit from earlier detection and prevention, the development of new screening technologies and chemoprevention ...

Protein profiling for detection of high risk breast cancer

PI: Semmes, John

Proteomic Data Resources for EDRN Ovary Cancer Researchers within the EDRN

PI: McIntosh, Martin

This project will generate a highly valuable data resource and make it available to all EDRN ovarian cancer researchers. The resource will include ...

Proteomic Genetic and Longitudinal Pathways to Ovarian Cancer Biomarkers

PI: Skates, Steven

Discovery and verification of early detection ovarian cancer plasma/serum biomarkers.

SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas

PI: Semmes, John

SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

PI: Cramer, Daniel

Phase II specimens from 160 ovarian cancer cases and 640 benign disease or general population controls were assembled from four Early Detection Research ...

Standard Specimen Reference Set: Breast

PI: Marks, Jeffrey

The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ...

Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates

PI: Li, Christopher

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Early diagnosis of triple negative breast cancer would likely have significant impact on overall breast cancer mortality. This proposal is designed to ...

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Year 2 Collaborative Project - UCSF and Battelle PNWD

PI: Zangar, Richard (Rick) C.

To evaluate the effects of receptor status on circulating biomarker levels.

pre-operative plevic mass study

PI: Cramer, Daniel

Data
Calendar

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Past Events

There are no past events.

Documents
 Title   Author   Type   Modified 
Clarifying the Risk of Breast Cancer in Women with Atypical Breast Lesions Heather Kincaid Folder Jan 05, 2012 04:31 PM
File OC Team Project January 2013 Teleconference Minutes Christos Patriotis File Jan 31, 2013 10:30 AM