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Biomarkers
SLPI
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical ...
SDC1
SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The SDC1 protein functions as an integral ...
IL6R
The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal ...
IGFBP2
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell ...
SEC23B
SEC23B is a member of the SEC23B/SEC24B family. SEC23B is a component of the COPII coat, that covers ER-derived vesicles involved in transport from the ...
GPR65
GPR65, a member of the G-protein coupled receptor 1 family, is a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. ...
SLC30A6
SLC30A6 is a zinc-efflux transporter which has been shown by similarity to be involved in distributing the cytoplasmic zinc to the trans-Golgi network (TGN) as ...
TNF
TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and ...
CCDC102B
CCDC102B, or coiled-coil domain-containing protein 102B, has two isoforms produced by alternative splicing.
FAM83H
FAM83H is a member of the FAM83 family and plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a ...
FJX1
FJX1 is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and ...
RMND5A
RMND5A (FLJ13910) is also known as required for meiotic nuclear division 5 homolog A (S. cerevisiae). There are two isoforms of this human protein, ...
CRIP2
Cysteine-rich intestinal protein 2 (CRIP2) has been shown to be involved in development. It is expressed in a variety of tissues, with particularly high ...
CA125
MUC16 (CA125) is a highly glycosylated sialomucin that is expressed on epithelial cell surface, especially on ovarian cancer cells. MUC16 is anchored to the ...
GPM6B
GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is ...
P2RY14
P2RY14, or GPR105, is a G-protein coupled receptor that responds to extracellular purine and pyrimidine nucleotides. P2RY14 is not activated by ATP, ADP, ...
TFCP2
From NCBI Gene: This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded ...
B7-H4
Highly glycosylated sialomucin; expressed on immune cells. Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, ...
FNDC3A
Fndc3a is a member of a three-gene family in mice. Mouse Fndc3a is composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a ...
SERPINH1
From NCBI Gene: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic ...
CA72-4
High-MW mucin-type glycoprotein expressed on epithelial cancer cells.
FZD10
FZD10 is a member of the frizzled gene family. The frizzled gene family encodes 7-transmembrane domain proteins that are receptors for the Wingless type MMTV ...
ZMYM6
ZMYM6 is an MYM zinc finger protein. Zinc fingers are DNA binding proteins located in the cell nucleus.
ZNF510
ZNF510 is a zinc finger protein thought to be involved in transcriptional regulation.
RAC3
From NCBI Gene: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily ...
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker ...
Cramer 5-marker panel for ovarian cancer
The PLCO phase III specimens (test half) revealed marker panels produced only marginal improvement over CA 125 alone and, in some case, worse performance. ...
TRIM32
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, ...
ALG10
ALG10 is a membrane associated protein found in the endoplasmic reticulum. It is responsible for adding the third glucose residue to the lipid-linked ...
HOXD1
From NCBI Gene: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a ...
CCL4
From NCBI Gene: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The ...
APOA1
APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for ...
HE4
11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of ...
CDH3
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein ...
FRS3
From NCBI Gene: This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and ...
BCL2L2
From NCBI Gene: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and ...
CEACAM5
From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the ...
PDCD6IP
From NCBI Gene: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle ...
CCL13
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of ...
DBT
From NCBI Gene: The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the ...
CCL17
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of ...
CA15-3
CA15-3 may be a molecular marker for ovarian cancer. Literature suggests that the concomitant measurement of CA15-3 with CA125 could be advantageous in the ...
ATP6AP1
ATP6AP1 is an integral membrane protein composed of at least 10 subunits. It is responsible for acidifying various eukaryotic intracellular organelles. ...
CSNK1E
CSNK1E is a serine/threonine protein kinase and a member of the casein kinase I protein family. Casein kinases are characterized by their preferential ...
SF3A1
From NCBI Gene: This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 ...
FOLH1B
FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related ...
ERBB2
ERBB2, often known as HER-2/neu, a single-pass type I membrane protein, is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine ...
CTBP1
From NCBI Gene: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may ...
PCDH17
PCDH17 is a member of the protocadherin gene family, a subfamily of the cadherin superfamily. PCDH17 has six extracellular cadherin domains, a transmembrane ...
FSH
Follicle stimulating hormone, a heterodimer glycoprotein of a common alpha chain and a unique beta chain which confers biological specificity to ...
WWC1
WWC1, or KIBRA, is a cytoplasmic phosphoprotein. Expression has been detected in the brain, heart, colon and kidney, as well as mammary epithelial cells ...
EFR3A
EFR3A (KIAA0143) is a membrane protein. Little is known about its function, although studies on the mouse homolog have suggested a role in hearing. It has ...
GH1
Growth hormone, a secreted protein which exists as a monomer, dimer, trimer, tetramer and pentamer and is disulfide-linked or non-covalently associated in ...
HOXA9
HOXA9 is a sequence-specific transcription factor. It is a member of the homeobox gene family. These transcription factors are spatially and temporally ...
AFP
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with ...
RAB5A
From UniProtKB/Swiss-Prot: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their ...
OLFML2B
OLFML2B is a secreted protein. The gene is conserved across many species. The protein is a homodimer.
SLC11A1
SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain ...
LZTS1
LZTS1 is a tumor suppressor protein that is widely expressed in normal tissues. It is involved in regulating cell growth and is also thought to interact with ...
SLC33A1
From NCBI Gene: The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 ...
LGALS3BP
LGALS3BP is a secreted protein that binds to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. Elevated levels of LGALS3BP have ...
IL6
Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In ...
VTA1
VTA1 (C6ORF55) is involved in activities of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in ...
IL10
Interleukin 10, a secreted protein belonging to the IL-10 family, is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. It ...
MPPED2
MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). ...
SPON2
SPON2, also known as spondin-2, is a cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. It binds directly to ...
ACKR3
ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not ...
B2M
B2M, a secreted protein belonging to the beta-2-microglobulin family, is a component of the class I major histocompatibility complex (MHC) on the surface of ...
Annexin 1
Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. ...
CDCP1
CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is ...
PRL
There is increasing evidence that prolactin (PRL), a hormone/cytokine, plays a role in breast, prostate, and colorectal cancers via local production or ...
DEFB1
DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the ...
EPB41L3
EPB41L3 protein is a critical growth regulator in the pathogenesis of meningiomas. There are three isoforms of this protein, produced by alternative splicing.
EGFL6
EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the ...
MPZL2
The EVA1, or MPZL2 gene is expressed in the thymus and in several epithelial structures early in embryogenesis. The protein MPZL2 displays an ability to ...
PPBP
CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant ...
EPSTI1
EPSTI1 is highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. There are three isoforms of this protein, ...
CCL11
Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two ...
SELL
From NCBI Gene and UniProtKB/Swiss-Prot: sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing ...
EGFR
EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor ...
ADAM12
ADAM12 is a member of the ADAM (a disintegrin and metalloprotease) protein family. ADAM family members are membrane-anchored proteins structurally related to ...
BDNF
BDNF (brain-derived neurotrophic factor) is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of ...
KLK6
Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control ...
ACTR3
The ACTR3 protein is a component of the ARP2/3 complex, which is essential to cell shape and motility.
GPR157
GPR157 is a multi-pass transmembrane G protein-coupled receptor protein. GPR157 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and ...
ATF3
ATF3 is a member of the the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. The ATF3 ...
EIF3E
From UniProtKB/Swiss-Prot: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation ...
KRT19
KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. ...
IGFBP1
IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a ...
MYOZ2
From NCBI Gene: The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in ...
C15orf48
C15orf48 is expressed mainly in adult stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. The gene was first identified in ...
SLAMF8
SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in ...
UBAP1
From NCBI Gene: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. ...
ROMA
The Risk of Ovarian Malignancy Algorithm (ROMA) algorithm was approved by the FDA in 2011. Research demonstrates that examining levels of HE4 and CA125 ...
MMP7
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as ...
BMX
BMX, or BMX non-receptor tyrosine kinase, belongs to the Tec kinase family. BMX, a non-receptor tyrosine kinase, plays a central but diverse modulatory role in ...
IGF2
IGF2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. The IGF2 gene is an imprinted gene and is ...
IL8
Interleukin 8 (IL8) is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that attracts neutrophils, ...
AKR1B1
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member ...
SOX2
From NCBI Gene: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic ...
MIF
MIF, a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation, plays a role in the regulation of macrophage function in host defense ...
MPO
Myeloperoxidase (MPO) is a lysosomal heme protein found at chromosomal location 17q23.1. It is produced as a single chain precursor that is cleaved into two ...
AKR1C2
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes ...
BAT4
GPANK1, also known as BAT4, is part of a cluster of genes, BAT1-BAT5. These genes are HLA-B associated transcripts, and are included in the human major ...
LEP
Leptin (LEP) is secreted by white adipocytes and plays a major role in the regulation of body weight. This protein, which acts through the leptin ...
MMP2
MMP2 is a member of the matrix metalloproteinase (MMP) family and is involved in many functions, such as remodeling of the vasculature, angiogenesis, tissue ...
ADIPOQ
From NCBI Gene: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. ...
GDF15
GDF15, also known as macrophage inhibitory cytokine 1, or MIC1, is a bone morphogenetic protein (BMP) belonging to the transforming growth factor-beta ...
ALPL
From NCBI Gene: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue ...
KLK8
KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin ...
TNFRSF1B
TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the ...
TSHB
TSH, a secreted protein belonging to the glycoprotein hormones subunit beta family, is essential for the control of thyroid structure and metabolism. The four ...
CCL22
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of ...
CCL26
From NCBI Gene: This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins ...
CCL2
CCL2, also known as MCP-1, is a member of the chemokine superfamily. Chemokines are a family of small cytokines. The four chemokine subfamilies are based on ...
ST14
ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this ...
TNFAIP1
The expression of this gene can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Mouse studies suggest the expression ...
BGLAP
BGLAP, also known as osteocalcin, makes up 1-2% of the total bone protein. It also binds strongly to apatite and calcium.
TNFAIP6
TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly ...
MSLN
Mesothelin, a cell surface antigen, was isolated using an antibody that reacts with ovarian cancers and mesotheliomas. Although the function of mesothelin is ...
LHB
The pituitary glycoprotein hormone family includes follicle stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG), and ...
CCL5
CCL5 (RANTES) is a chemokine, a subfamily of cytokines. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory ...
SCGB2A1
SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is ...
IL2RA
The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of ...
Projects/Protocols

Projects

There are currently no projects of which this group is a part.

Protocols

Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer

PI: Cramer, Daniel

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

BBD Reference Set Application: Jeffery Marks-Duke (2015)

PI: Marks, Jeffrey

BRSCW Ref Set Application: Anna Lokshin - Univ of Pitts (2008)

PI: Lokshin, Anna

Validate biomarkers identified using Luminex bead-based arrays in case/control sets (individual samples) in reference sets

BRSCW Reference Set Application: Anu Mathew - Meso Scale (2006)

PI: Mathew, Anu

46 markers were tested on pooled case samples and on control samples.

BRSCW Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Examine kallikreins as ovarian cancer biomarkers

BRSCW Reference Set Application: GeorgeTuszynski - Temple University (2012)

PI: Tuszynski, George

The marker GASP-1 was evaluated in the pooled breast cancer reference set. It did not seem to be elevated relative to controls.

BRSCW Reference Set Application: James Morre - NOX Technologies Inc. (2009)

PI: Morre, D. James

Evaluation using NOX Technologies ECTO-NOX blot diagnostic 2-D gel electrophoretic cancer detection system in combination with a sandwich ELISA of our ...

BRSCW Reference Set Application: Joe Buechler - Biosite Inc (2009)

PI: Buechler, Joe

Over 40 marker assays are available to run on the samples. These include markers such as Osteopontin, Mesothelin, Periostin, Endoglin, intestinal Fatty Acid ...

BRSCW Reference Set Application: Karen Abbott -University of Arkansas (2014)

PI: Abbott, Karen

Our earlier glycoproteomic studies have identified bisecting glycoslyation and core fucosylation changes on particular glycoproteins in endometrioid ovarian ...

BRSCW Reference Set Application: Michael Birrer-Massachusetts General Hospital (2013)

PI: Birrer, Michael

Validate FGF18 and GPR172A in reference set

BRSCWRef Set Application: Michael Wilson - EIC Laboratories, Inc (2007)

PI: Wilson, Michael S.

The selected markers are well established as "standard" markers fo ra range of cancers, and have been analyzed in the reference set as a benchmark for ...

Benign Breast Disease Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays

PI: LaBaer, Joshua

Cancer patients spontaneously generate autoantibodies (AAb) to tumor-derived proteins. To detect AAb, we have probed novel high-density custom protein ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays: EDRN Supplement

PI: Anderson, Karen

The overall goal of this project application for the EDRN set-aside funds is to focus our collaborative efforts to identify p53 mutation-specific antibody ...

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Reference Sets for Cancers in Women

PI: Cramer, Daniel

The purpose of this study is to develop a standard reference set of specimens for use by investigators participating in the National Cancer Institutes Early ...

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancer

PI: Li, Christopher

Distinguishing aggressive cancers from non-aggressive or non-progressing cancers is an issue of both clinical and public health importance particularly for ...

Body Fluids as a Source of Diagnostic Biomarkers: Breast

PI: Semmes, John

Breast Cancer: subgroups specific blood-biomarkers for early / predictive diagnosis and personalized treatment

PI: Golubnitschaja, Prof. Dr. Olga

Breast-conserving lumpectomy followed by radiation therapy has been shown to be an alternative strategy, competitive to mastectomy, in preventing mortality ...

Breast Ductal Lavage Fluid Specimen Bank

PI: Trock, Bruce

Breast Reference Set Application: Anu Mathew-Meso Scale (2012)

PI: Mathew, Anu

Using a subset of plasma samples (n=505) from the reference set, we analyzed 90 proteins by multiplexed immunoassays for their potential utility as diagnostic ...

Breast Reference Set Application: Chris Li-FHCRC (2014)

PI: Li, Christopher

This application proposes to use Reference Set #1. We request access to serum samples collected at the time of breast biopsy from subjects with IC (n=30) or ...

Breast Reference Set Application: Chris Li-FHCRC (2015)

PI: Li, Christopher

Breast Reference Set Application: GeorgeTuszynski-Temple (2012)

PI: Tuszynski, George

As recommended by the review committee, we will analyze 30 invasive cancer cases and 30 benign controls from the EDRN breast reference set. Cases and controls ...

Breast Reference Set Application: Karen Abbott- University of Arkansas (2013)

PI: Abbott, Karen

We are evaluating whether detection of a tumor-specific N-linked glycosylation known as B 1,6 branched N-glycan present on the glycoprotein periostin in breast ...

Breast Reference Set Application: Karen Anderson-ASU (2014)

PI: Anderson, Karen

In order to increase the predictive value of tumor-specific antibodies for use as immunodiagnostics, our EDRN BDL has developed a novel protein microarray ...

Breast Reference Set Application: Pinku Mukherjee-CanDiag (2014)

PI: Mukherhjee, Pinku

We would like to get all three sets of specimens, however, we are requesting Specimen Set 1 first: 30 subjects with invasive cancer and 30 subjects with benign ...

Breast Reference Set Application: Richard Zangar-PNNL (2012)

PI: Zangar, Richard (Rick) C.

Our immediate goal is to define a set of biomarkers (composed of circulating plasma proteins) that can be used to distinguish between true and false screens, ...

Breast tissue array

PI: Chia, David

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Clinical Validation of Molecular Signatures of Cervical Neoplasia

PI: Unger, Elizabeth R.

DCIS Team Project

PI: Li, Christopher

Both overtreatment and undertreatment of DCIS are pervasive problems given that no useful approaches for identifying which DCIS patients are likely or highly ...

Detecting Breast Cancer Signatures in Body Fluids

PI: Trock, Bruce

Detecting breast cancer protein signatures in body fluid

PI: Semmes, John

Detection of Serum Markers of Breast Cancer by SELDI

PI: Marks, Jeffrey

Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study

PI: Esserman, Laura J.

Development of FISH-based assay for early detection of high grade cervical dysplasia

PI: Unger, Elizabeth R.

Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets

PI: Esserman, Laura J.

EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project

PI: Li, Christopher

To identify promising candidate plasma early detection biomarkers specific to different molecular subtypes of breast cancer using preclinical specimens from ...

EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial

PI: Li, Christopher

Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ...

EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples

PI: Li, Christopher

We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ...

EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples

PI: Li, Christopher

The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ...

EDRN Longitudinal Serum Biorepository

PI: Lynch, Henry

Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ...

Early Detection Research Network Registry for Hereditary Cancer

PI: Lynch, Henry

The EDRN High Risk Registry (HRR)recruits individuals that carry germline mutations for hereditary cancer syndromes, who are willing to participate in ...

Early Detection of Breast Cancer Using Autoantibody Markers

PI: Tainsky, Michael A.

To identify large numbers of antigens that can be used to recognize the presence of cancer by detecting antibodies to tumor proteins in the serum of the test ...

Establishment of a serum standard for use in high-throughput proteomic

PI: Semmes, John

Expression based markers for breast cancer detection

PI: Marks, Jeffrey

High-Throughput Evaluation of Breast Cancer Markers

PI: Zangar, Richard (Rick) C.

The objective of this study is to use a combination of AMT proteomics and ELISA microarray testing to discover and validate novel biomarkers for breast cancer.

Identification of New Markers in Normal and Abnormal Pap Smears

PI: Unger, Elizabeth R.

National Ovarian Cancer Early Detection Program Blood and Genetics

PI: Fishman, David

Ovarian Cancer Screening Pilot Trial In High Risk Women

PI: Lynch, Henry

BACKGROUND: No proven ovarian cancer (OC) screening strategy exists for women who are at increased risk for the disease. A risk of ovarian cancer algorithm ...

PLCO Ovarian Phase III Validation Study

PI: Cramer, Daniel

Our preliminary data indicate that the performance of CA 125 as a screening test for ovarian cancer can be improved upon by additional biomarkers. With ...

PTM Microarray: Request for Year 3 Set-Aside Funds

PI: Zangar, Richard (Rick) C.

We hypothesize that PTMs on proteins that are secreted by the breast will provide a more sensitive method for detecting breast cancer than analysis of the ...

Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer

PI: Mor, Gil

While all cancer patients could potentially benefit from earlier detection and prevention, the development of new screening technologies and chemoprevention ...

Pre-operative plevic mass study

PI: Cramer, Daniel

Protein profiling for detection of high risk breast cancer

PI: Semmes, John

Proteomic Data Resources for EDRN Ovary Cancer Researchers within the EDRN

PI: McIntosh, Martin

This project will generate a highly valuable data resource and make it available to all EDRN ovarian cancer researchers. The resource will include ...

Proteomic Genetic and Longitudinal Pathways to Ovarian Cancer Biomarkers

PI: Skates, Steven

Discovery and verification of early detection ovarian cancer plasma/serum biomarkers.

SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas

PI: Semmes, John

SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

PI: Cramer, Daniel

Create a new set of phase II specimens (160 cases with pre-operative bloods representing major histologic types and including 80 early-staged and 80 ...

Standard Specimen Reference Set: Breast

PI: Marks, Jeffrey

The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ...

Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates

PI: Li, Christopher

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ...

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Year 2 Collaborative Project - UCSF and Battelle PNWD

PI: Zangar, Richard (Rick) C.

To evaluate the effects of receptor status on circulating biomarker levels.

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Documents
 Title   Author   Type   Modified 
Clarifying the Risk of Breast Cancer in Women with Atypical Breast Lesions Heather Kincaid Folder Jan 05, 2012 04:31 PM
File OC Team Project January 2013 Teleconference Minutes Christos Patriotis File Jan 31, 2013 10:30 AM
File February 2015 Breast/GYN Collaborative Group Call Minutes Heather Kincaid File Mar 29, 2015 02:03 PM