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YES

Basics

Aliases:
This biomarker is also known as:
  • Yamaguchi Sarcoma Oncogene,
  • Proto-Oncogene C-Yes,
  • P61-YES,
  • Cellular Yes-1 Protein,
  • Tyrosine-Protein Kinase Yes,
  • V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1,
  • YES1,
  • HsT441,
  • Proto-Oncogene Tyrosine-Protein Kinase YES,
  • C-YES,

View in BioMuta

Description…

YES1, also known as YES, is a non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. It is the cellular homolog of the Yamaguchi sarcoma virus oncogene and belongs to the src family of proteins. YES1 is involved in many phosphorylation reactions, including a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Two
QA State: Curated

Overview

YES has not been identified previously in serum as a lung cancer biomarker and represents a novel finding in the aptamer proteomic technology study (Ostroff et al, 2010). YES was observed up-regulated in lung cancer in this study.

Performance Comment

YES is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement