Aliases:This biomarker is also known as:
- X-box binding protein 1,
- X-box-binding protein 1,
- tax-responsive element-binding protein 5,
- Tax-responsive element-binding protein 5,
XBP1 is a transcription factor involved in hepatocyte growth, differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 also plays a role in activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) during endoplasmic reticulum stress. There is an XBP1 pseudogene on chromosome 5.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
XBP1 is also an estrogen-regulated gene and strongly correlates with estrogen receptor alpha (ERα) expression in breast cancers.
XBP1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells.