Wu 6-marker phage peptide panel for Lung Cancer
The six-phage peptide detector stands out as a promising diagnostic biomarker for NSCLC. The peptide panel could be used to diagnose non-small cell lung cancer and to differentiate between non-small cell lung cancer and chronic obstructive pulmonary diseases. One of the six phage peptides shows 100% homology to olfactomedin 1. (Clin Cancer Res. 2010 Jul 15;16(14):3760-8. doi: 10.1158/1078-0432.CCR-10-0193) The other five peptides were homologous to proteins in a blastp search, but the homology was not high enough to positively identify the peptides.
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The six-phage peptide detector could be used to diagnose NSCLC at early stage and discriminate NSCLC and chronic obstructive pulmonary diseases. Chemotherapy significantly reduced the seroreactivity of the six-phage peptide clones. The six-phage peptide detector can be used as a novel method for noninvasive diagnosis and screening of NSCLC in high-risk populations. However, it is unlikely to be used as biomarkers for indicating the relapse of NSCLC after chemotherapy. (Clin Cancer Res. 2010 Jul 15;16(14):3760-8. doi: 10.1158/1078-0432.CCR-10-0193)
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