Aliases:This biomarker is also known as:
- ubiquitin-60S ribosomal protein L40,
- ubiquitin carboxyl extension protein 52,
- ubiquitin-52 amino acid fusion protein,
- ubiquitin A-52 residue ribosomal protein fusion product 1,
- 60S ribosomal protein L40,
Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different proteins. There are four genes that code for ubiquitin: UBB, UBC, RPS27A, and UBA52. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. This gene, UBA52, encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.
|QA State:||Under Review|
There are no datasets associated with this biomarker.