Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health


Personal tools

You are here: Home / Biomarkers / TSPO



This biomarker is also known as:
  • PBRS,
  • PBS,
  • Mitochondrial benzodiazepine receptor,
  • benzodiazapine receptor (peripheral),
  • translocator protein,
  • pk18,
  • mDRC,
  • benzodiazepine peripheral binding site,
  • BZRP,
  • peripheral-type benzodiazepine receptor,
  • IBP,
  • Peripheral-type benzodiazepine receptor,
  • MBR,
  • mitochondrial benzodiazepine receptor,
  • PTBR,
  • PKBS,
  • PBR,
  • translocator protein (18kDa),
  • BPBS,
  • DBI,

View in BioMuta


TSPO is a conserved protein found at the outer mitochondrial membrane. TSPO interacts with some benzodiazepines and isoquinoline carboxamides and has different affinities than its endogenous counterpart. TSPO is also involved in the transport of porphyrins and heme.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


The TSPO gene is known to be over-expressed in highly aggressive tumors, especially those of the breast. Increasing levels of the TSPO protein are correlated with more advanced stages of breast cancer. Higher TSPO levels are found in estrogen receptor (ER)-negative breast tumors, compared with ER-positive tumors.

Performance Comment

TSPO was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.