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TRAF4

Basics

Aliases:
This biomarker is also known as:
  • malignant 62,
  • cysteine-rich domain associated with ring and TRAF domain,
  • tumor necrosis receptor-associated factor 4A,
  • RING finger protein 83,
  • cysteine-rich domain associated with RING and Traf domains protein 1,
  • MLN 62,
  • metastatic lymph node gene 62 protein,
  • Cysteine-rich domain associated with RING and Traf domains protein 1,
  • MLN62,
  • TNF receptor-associated factor 4,
  • Metastatic lymph node gene 62 protein,
  • RNF83,
  • CART1,

View in BioMuta

Description…

TRAF4 is a member of the TNF receptor associated factor (TRAF) family. Members of the TRAF family are the major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily. TRAF4 is involved in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

The TRAF4 gene is amplified in breast carcinoma. TRAF4 is also involved in the regulation of the TGF-β pathway and in subsequent breast cancer pathogenesis.

Performance Comment

TRAF4 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html