Aliases:This biomarker is also known as:
- tumor necrosis factor receptor superfamily, member 21,
- death receptor 6,
TNFRSF21, a member of the TNF-receptor superfamily and a single-pass type I membrane protein, has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. TNFRSF21 is required for both normal cell body death and axonal pruning. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
TNFRSF21 is a secreted molecule that is selectively expressed in tumor vasculature and represents a promising target as a serum biomarker.
TNFRSF21 protein is detectable in sera of epithelial ovarian cancer patients and at higher levels compared with healthy donors.