THBS1
Basics
Aliases:
This biomarker is also known as:- THBS-1,
- TSP-1,
- Thrombospondin-1,
- THBS,
- TSP,
- thrombospondin-1p180,
Description…
TSP is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. It has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
Attributes
| QA State: | Accepted |
|---|---|
| Type: | Protein |
| Short Name: |
Organs
The following organs have data associated with this biomarker…
Prostate
Attributes
| Phase: | Two |
|---|---|
| QA State: | Accepted |
Overview
Blood protein markers that provide more accurate or earlier diagnosis of prostate cancer should have a positive impact on prostate cancer treatment and management. Experimental evidence shows that thrombospondin-1 levels are elevated in patients with benign prostatic disease and repressed in patients with prostate cancer. Thrombospondin-1 levels do not correlate with prostate-specific antigen (PSA) levels and differentiate benign from malignant disease with 79% sensitivity and 81% specificity. The measurement of thrombospondin-1 could be used to assist the decision to obtain a biopsy in men with suspected prostate cancer, which could lead to a reduction in the number of unnecessary prostatic biopsies.
Performance Comment
TSP did not, for the populations tested in these experiments, show strong pre-diagnostic performance. This biomarker has not moved on to Phase 3 study.
Supporting Study Data
The following studies/protocols provide evidence supporting THBS1 indications for the Prostate…
Prostate Rapid Pre-Validation Set
Determine which markers move to validation using the prospectie prostate reference set samples.
View more about this studyBiomarker Characteristics Summary
No statistics found.
Decision Rule
No clinically useful decision rule found.
Additional Study-Specific Protocols
Study-Specific Publications
No study-specific publications defined.
Study-Specific Resources
No study-specific resources defined.
Prostate Rapid Reference Set Application: Haab - Van Andel (2006)
To evaluate TSP-1 as a marker to specifically detect prostate cancer
View more about this studyBiomarker Characteristics Summary
| Notes | Sensitivity | Specificity | Prevalence | NPV | PPV | Specific Assay Type |
|---|---|---|---|---|---|---|
| Measured among 123 samples (60 controls and 63 cases). Among the cases, 33 had low Gleason grade (<7) and 30 had high Gleason grade (>=7). When comparing cases with Gleason grade >=7 (n=30) to the pool of controls and cases with Gleason grade <7 (n=93), for the average of normalized TSP, AUC was 0.54 (0.42, 0.66). | 90.0 | 13.0 | 0.0 | |||
| Measured among 123 samples (60 controls and 63 cases). Among the cases, 33 had low Gleason grade (<7) and 30 had high Gleason grade (>=7). For the average of unnormalized TSP, AUC was 0.52 (0.42, 0.62). | 90.0 | 10.0 | 0.0 | |||
| Measured among 123 samples (60 controls and 63 cases). Among the cases, 33 had low Gleason grade (<7) and 30 had high Gleason grade (>=7). For the average of normalized TSP, AUC was 0.5 (0.4, 0.61). | 90.0 | 5.0 | 0.0 | |||
| Measured among 123 samples (60 controls and 63 cases). Among the cases, 33 had low Gleason grade (<7) and 30 had high Gleason grade (>=7). When comparing cases with Gleason grade >=7 (n=30) to the pool of controls and cases with Gleason grade <7 (n=93), for the average of unnormalized TSP, AUC was 0.53 (0.41, 0.66). | 90.0 | 6.0 | 0.0 |
Decision Rule
No clinically useful decision rule found.
Additional Study-Specific Protocols
Study-Specific Publications
No study-specific publications defined.
Study-Specific Resources
No study-specific resources defined.
Organ-Specific Protocols
No organ-specific protocols defined.
Organ-Specific Publications
Organ-Specific Resources
Studies
No associated studies or protocols found.
