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TFF3

Basics

Aliases:
This biomarker is also known as:
  • TFI,
  • Polypeptide P1.B,
  • P1B,
  • ITF,
  • HP1.B,
  • Trefoil Factor 3 (Intestinal),
  • HITF,
  • Intestinal Trefoil Factor,
  • Trefoil Factor 3,
  • Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11,

View in BioMuta

Description…

TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides.

Attributes

QA State: Curated
Type: Gene
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: Two
QA State: Curated

Overview

Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer.

Performance Comment

Increased TFF3 transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement