Aliases:This biomarker is also known as:
- stomatin (EPB72)-like 2,
- EPB72-like protein 2,
- stomatin-like 2,
- stomatin-like protein 2,
STOML2, also known as SLP-2 or stomatin-like 2, is a mitochondrial protein that is thought to regulate the biogenesis and the activity of mitochondria, and through this regulation play a role in cell activities such as cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
STOML2, also known as SLP-2 or stomatin-like 2, is overexpressed in many cancers, including breast cancer. STOML2 (SLP-2) expression and ERBB2 (HER-2/neu) protein expression are associated with decreased breast cancer patient survival.
STOML2 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival.