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ST14

Basics

Aliases:
This biomarker is also known as:
  • Q9Y5Y6,
  • MTSP1,
  • OTTHUMP00000230932,
  • Tumor-associated differentially-expressed gene 15 protein,
  • EC 3.4.21,
  • SNC19,
  • suppressor of tumorigenicity 14 protein,
  • MT-SP1,
  • TADG15,
  • HAI,
  • EC 3.4.21.109,
  • Serine protease 14,
  • Prostamin,
  • prostamin,
  • Matriptase,
  • Membrane-type serine protease 1,
  • suppression of tumorigenicity 14 (colon carcinoma),
  • TMPRSS14,
  • OTTHUMP00000230931,
  • Serine protease TADG-15,
  • PRSS14,
  • suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin),
  • tumor associated differentially expressed gene 15 protein,

View in BioMuta

Description…

ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

ST14 localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

ST14 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ST14 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html