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Spira 80-marker panel plus clinical factors



QA State: Curated
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This clinicogenomic model incorporates the gene expression pattern of histologcially normal large airway epithelial cells collected at time of bronchoscopy (see 'Spira 80-marker panel for lung cancer') with clinical parameters about lung cancer risk.

Panel Details

No member markers defined for this panel.


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: One
QA State: Curated


The Spira 80-marker panel for lung cancer biomarker was developed by using the gene expression patterns obtained from cytologically normal large airway epithelial cells from smokers undergoing bronchoscopy for suspiction of lung cancer. The results from the bronchosopy are 100% specific for lung cancer, but has a limited sensitivity of 30-80% depending ont he stage and location of the cancer. Therefore, difficult decisions must be made regarding care and treatment of patients with potentially early-stage, treatable, curable cancers. By adding the clinical factors to the 80-marker panel, the predictive nature of the model has been improved.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


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2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.