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SELL

Basics

Aliases:
This biomarker is also known as:
  • PLNHR,
  • LEU8,
  • pln homing receptor,
  • leukocyte surface antigen Leu-8,
  • LYAM1,
  • gp90-MEL,
  • lymph node homing receptor,
  • selectin L,
  • Leukocyte-endothelial cell adhesion molecule 1,
  • LECAM1,
  • L-selectin,
  • LNHR,
  • CD62 antigen-like family member L,
  • Lymph node homing receptor,
  • Leukocyte surface antigen Leu-8,
  • LAM1,
  • hLHRc,
  • sL-selectin,
  • Leukocyte adhesion molecule 1,
  • CD62L,
  • lymphocyte adhesion molecule 1,
  • leukocyte-endothelial cell adhesion molecule 1,
  • Leu-8,
  • LAM-1,
  • LSEL,
  • TQ1,
  • Lyam-1,
  • CD62L antigen,

View in BioMuta

Description…

sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. SELL mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes and promotes initial tethering and rolling of leukocytes in endothelia, facilitating their migration into secondary lymphoid organs and inflammation sites. SELL contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. Alternatively spliced transcript variants have been found for this gene.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Lung

Attributes

Phase: Two
QA State: Curated

Overview

SELL has not been identified previously in serum as a lung cancer biomarker and represents a novel finding in the aptamer proteomic technology study (Ostroff et al, 2010). A decreased level of SELL was seen in the serum of lung cancer patients compared to controls in this study.

Performance Comment

sL-selectin, also known as SELL, is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html