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SCGB2A1

Basics

Aliases:
This biomarker is also known as:
  • LIPHC,
  • LPHC,
  • UGB3,
  • Lacryglobin,
  • lipophilin C,
  • O75556,
  • Lipophilin-C,
  • mammaglobin B,
  • mammaglobin-B,
  • MGC71973,
  • secretoglobin, family 2A, member 1,
  • lipophilin-C,
  • mammaglobin 2,
  • MGB2,
  • Mammaglobin-2,
  • Secretoglobin family 2A member 1,
  • lacryglobin,
  • mammaglobin-2,

View in BioMuta

Description…

SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is normally expressed in the thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

SCGB2A1, also known as MGB2 or mammaglobin B, is highly homologous to mammaglobin A (MGB1), which is overexpressed in breast cancer. SCGB2A1 has also been found to be overexpressed in primary breast cancers. Recently SCGB2A1 was found to be a top differentially expressed gene in ovarian cancer.

Performance Comment

SCGB2A1 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. SCGB2A1 was not in the group of 13 selected for further validation.

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html