RPSA
Basics
Aliases:
This biomarker is also known as:- 37LRP,
- LBP/p40,
- 67LR,
- LamR,
- laminin receptor 1 (67kD, ribosomal protein SA),
- LAMR1,
- laminin receptor 1,
- ribosomal protein SA,
- 40S ribosomal protein SA,
- Laminin-binding protein precursor p40,
- 67kD, ribosomal protein SA,
- Multidrug resistance-associated protein MGr1-Ag,
- LRP,
- LAMBR,
- 34/67 kDa laminin receptor,
- RSSA,
- p40,
- Colon carcinoma laminin-binding protein,
- LBP,
- NEM/1CHD4,
- LRP/LR,
Description…
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The amino acid sequence of laminin receptor 1 is highly through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. LAMR1 antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.
Attributes
| QA State: | Accepted |
|---|---|
| Type: | Protein |
| Short Name: |
Datasets
Organs
The following organs have data associated with this biomarker…
Lung
Attributes
| Phase: | Three |
|---|---|
| QA State: | Under Review |
Overview
LAMR1, previously found to be the target of autoantibodies in newly diagnosed subjects with lung cancer, is also associated with autoantibodies in sera collected at the pre-symptomatic stage. These findings suggest potential utility of an approach to diagnosis of lung cancer before onset of symptoms that includes screening for autoantibodies to defined antigens, including LAMR1.
Performance Comment
The findings of this study suggest potential utility of an approach to diagnosis of lung cancer before onset of symptoms that includes screening for autoantibodies to defined antigens. Investigation of LAMR1 (RPSA) is ongoing.
Supporting Study Data
The following studies/protocols provide evidence supporting RPSA indications for the Lung…
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques
1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers before the clinical diagnosis, evaluating sensitivity and specificity by time before diagnosis, treatment arm, gender, histologic type, and smoking status. 1.2 To determine whether a pattern of occurrence of autoantibodies in lung cancer sera may be diagnostic of lung cancer that is not dependent on the occurrence of any particular autoantibody. 1.3 To compare the findings for individual biomarker candidates and combinations of biomarker candidates in participants who were current smokers versus former smokers.
View more about this studyBiomarker Characteristics Summary
| Notes | Sensitivity | Specificity | Prevalence | NPV | PPV | Specific Assay Type |
|---|---|---|---|---|---|---|
| Individual sera collected from 85 subjects within a year prior to a diagnosis of lung cancer and 85 matched controls from the CARET cohort were used in this analysis. Sam Hanash laboratory. | 51.0 | 82.0 | 0.0 |
Decision Rule
PMID:18794547
Additional Study-Specific Protocols
Study-Specific Publications
- Occurrence of Autoantibodies to Annexin I, 14-3-3 Theta and LAMR1 in Prediagnostic Lung Cancer Sera.
Study-Specific Resources
Organ-Specific Protocols
No organ-specific protocols defined.
Organ-Specific Publications
No organ-specific publications defined.
Organ-Specific Resources
No organ-specific resources defined.
Studies
No associated studies or protocols found.
Publications
- Occurrence of Autoantibodies to Annexin I, 14-3-3 Theta and LAMR1 in Prediagnostic Lung Cancer Sera.
- Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.
- Isolation of a laminin-binding protein from muscle cell membranes.
- Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein.
- Evidence for a precursor of the high-affinity metastasis-associated murine laminin receptor.
- Autoantibody profiling for cancer detection.
